Effect of Bicarbonate on Stability of the Gallium-Transferrin Complex
When gallium citrate is injected intravenously the gallium is rapidly transchelated to transferrin. If the stability of the gallium-transferrin association is sufficiently strong it should be a good macromolecular tracer suitable for quantitative measurements of vascular permeability. Studies of the...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1991-07, Vol.32 (7), p.1439-1441 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Staker, Bart L Graham, Michael M Evans, Margaret L |
| description | When gallium citrate is injected intravenously the gallium is rapidly transchelated to transferrin. If the stability of the gallium-transferrin association is sufficiently strong it should be a good macromolecular tracer suitable for quantitative measurements of vascular permeability. Studies of the stability of the gallium transferrin complex in human plasma and serum were done using ultrafiltration and dialysis. It was found that the stability was sensitive to bicarbonate level. Above 13 mM of bicarbonate, 97%-99% of the gallium is bound to molecules greater than 10,000 MW by ultrafiltration. However, at 10 mM binding is 95% and at 7 mM 83%. Similar results were obtained with dialysis. This suggests the gallium-transferrin complex may not be sufficiently stable for quantitative measures of vascular permeability, particularly if the bicarbonate concentration is low. |
| format | Article |
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If the stability of the gallium-transferrin association is sufficiently strong it should be a good macromolecular tracer suitable for quantitative measurements of vascular permeability. Studies of the stability of the gallium transferrin complex in human plasma and serum were done using ultrafiltration and dialysis. It was found that the stability was sensitive to bicarbonate level. Above 13 mM of bicarbonate, 97%-99% of the gallium is bound to molecules greater than 10,000 MW by ultrafiltration. However, at 10 mM binding is 95% and at 7 mM 83%. Similar results were obtained with dialysis. This suggests the gallium-transferrin complex may not be sufficiently stable for quantitative measures of vascular permeability, particularly if the bicarbonate concentration is low.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 2066803</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Bicarbonates - blood ; Dialysis ; Drug Stability ; Humans ; In Vitro Techniques ; Organometallic Compounds - blood ; Transferrin - metabolism ; Ultrafiltration</subject><ispartof>The Journal of nuclear medicine (1978), 1991-07, Vol.32 (7), p.1439-1441</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2066803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staker, Bart L</creatorcontrib><creatorcontrib>Graham, Michael M</creatorcontrib><creatorcontrib>Evans, Margaret L</creatorcontrib><title>Effect of Bicarbonate on Stability of the Gallium-Transferrin Complex</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>When gallium citrate is injected intravenously the gallium is rapidly transchelated to transferrin. If the stability of the gallium-transferrin association is sufficiently strong it should be a good macromolecular tracer suitable for quantitative measurements of vascular permeability. Studies of the stability of the gallium transferrin complex in human plasma and serum were done using ultrafiltration and dialysis. It was found that the stability was sensitive to bicarbonate level. Above 13 mM of bicarbonate, 97%-99% of the gallium is bound to molecules greater than 10,000 MW by ultrafiltration. However, at 10 mM binding is 95% and at 7 mM 83%. Similar results were obtained with dialysis. This suggests the gallium-transferrin complex may not be sufficiently stable for quantitative measures of vascular permeability, particularly if the bicarbonate concentration is low.</description><subject>Bicarbonates - blood</subject><subject>Dialysis</subject><subject>Drug Stability</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Organometallic Compounds - blood</subject><subject>Transferrin - metabolism</subject><subject>Ultrafiltration</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj0tLAzEYRYMotVZ_gjArXQ3k0TxmqaVWoeDCug7JmM9JyWRqMoP23zuls7jcxTlcuBdoTjjjJRdCXqI5JoKUnGN-jW5y3mOMhVJqhmYUC6Ewm6P1GsDVfdFB8exrk2wXTe-KLhYfvbE--P54Yn3jio0JwQ9tuUsmZnAp-VisuvYQ3N8tugITsrubeoE-X9a71Wu5fd-8rZ62ZUOZ6ktwFQFcSUpry6yU3IBSHC8lsXwpLQHDKQanGKHVGAKV5YYLIIZh4ATYAj2cdw-p-xlc7nXrc-1CMNF1Q9ZqvFUxLkbxfhIH27ovfUi-Nemop98jfzzzxn83vz45HYc6OJNO8j62jGqpyZJV7B9N0mF9</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>Staker, Bart L</creator><creator>Graham, Michael M</creator><creator>Evans, Margaret L</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19910701</creationdate><title>Effect of Bicarbonate on Stability of the Gallium-Transferrin Complex</title><author>Staker, Bart L ; Graham, Michael M ; Evans, Margaret L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-fe91f09722cb3b775af8850471b547b1fa520fe831293121f9b5a56f1a30f51f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Bicarbonates - blood</topic><topic>Dialysis</topic><topic>Drug Stability</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Organometallic Compounds - blood</topic><topic>Transferrin - metabolism</topic><topic>Ultrafiltration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Staker, Bart L</creatorcontrib><creatorcontrib>Graham, Michael M</creatorcontrib><creatorcontrib>Evans, Margaret L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staker, Bart L</au><au>Graham, Michael M</au><au>Evans, Margaret L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Bicarbonate on Stability of the Gallium-Transferrin Complex</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>32</volume><issue>7</issue><spage>1439</spage><epage>1441</epage><pages>1439-1441</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>When gallium citrate is injected intravenously the gallium is rapidly transchelated to transferrin. If the stability of the gallium-transferrin association is sufficiently strong it should be a good macromolecular tracer suitable for quantitative measurements of vascular permeability. Studies of the stability of the gallium transferrin complex in human plasma and serum were done using ultrafiltration and dialysis. It was found that the stability was sensitive to bicarbonate level. Above 13 mM of bicarbonate, 97%-99% of the gallium is bound to molecules greater than 10,000 MW by ultrafiltration. However, at 10 mM binding is 95% and at 7 mM 83%. Similar results were obtained with dialysis. This suggests the gallium-transferrin complex may not be sufficiently stable for quantitative measures of vascular permeability, particularly if the bicarbonate concentration is low.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>2066803</pmid><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 1991-07, Vol.32 (7), p.1439-1441 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Bicarbonates - blood Dialysis Drug Stability Humans In Vitro Techniques Organometallic Compounds - blood Transferrin - metabolism Ultrafiltration |
| title | Effect of Bicarbonate on Stability of the Gallium-Transferrin Complex |
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