Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation
Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K +-evoked CCKLM overflow was reduced b...
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| Veröffentlicht in: | Neuroscience letters 1991-04, Vol.124 (2), p.204-207 |
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| creator | Benoliel, J.J. Bourgoin, S. Mauborgne, A. Legrand, J.C. Hamon, M. Cesselin, F. |
| description | Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K
+-evoked CCKLM overflow was reduced by 0.1–10 μM of the μ agonist DAGO or 10 nM to 3 μM of the δ agonist DTLET. By contrast, at a higher concentration (10 μM), the latter drug as well as morphine enhanced CCKLM overflow. Although inactive alone, the κ opioid agonist U 50488 H (1 μM) prevented the inhibitory effect of DAGO without affecting that of DTLET. These data suggest that an opioid acting through the stimulation of μ, δ and κ receptors (such as morphine) should produce a net increase in the spinal release of CCK. |
| doi_str_mv | 10.1016/0304-3940(91)90094-A |
| format | Article |
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+-evoked CCKLM overflow was reduced by 0.1–10 μM of the μ agonist DAGO or 10 nM to 3 μM of the δ agonist DTLET. By contrast, at a higher concentration (10 μM), the latter drug as well as morphine enhanced CCKLM overflow. Although inactive alone, the κ opioid agonist U 50488 H (1 μM) prevented the inhibitory effect of DAGO without affecting that of DTLET. These data suggest that an opioid acting through the stimulation of μ, δ and κ receptors (such as morphine) should produce a net increase in the spinal release of CCK.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(91)90094-A</identifier><identifier>PMID: 1648690</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ; Analgesics - pharmacology ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Cholecystokinin - metabolism ; Cholecystokinin, In vitro release ; DAGO ; DTLET ; Enkephalin, Ala-MePhe-Gly ; Enkephalin, Leucine - analogs & derivatives ; Enkephalin, Leucine - pharmacology ; Enkephalins - pharmacology ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Male ; Narcotic Antagonists ; Oligopeptides - pharmacology ; Opioid receptor ; Pyrrolidines - pharmacology ; Rat spinal cord ; Rats ; Rats, Inbred Strains ; Receptors, Opioid - drug effects ; Receptors, Opioid - physiology ; Receptors, Opioid, delta ; Receptors, Opioid, kappa ; Receptors, Opioid, mu ; Spinal Cord - metabolism ; U 50488 H ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1991-04, Vol.124 (2), p.204-207</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-f3f16bc3152908f8bafcf93119577c422067244e34e8a2febce192c5ccfce2593</citedby><cites>FETCH-LOGICAL-c333t-f3f16bc3152908f8bafcf93119577c422067244e34e8a2febce192c5ccfce2593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030439409190094A$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19707630$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1648690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benoliel, J.J.</creatorcontrib><creatorcontrib>Bourgoin, S.</creatorcontrib><creatorcontrib>Mauborgne, A.</creatorcontrib><creatorcontrib>Legrand, J.C.</creatorcontrib><creatorcontrib>Hamon, M.</creatorcontrib><creatorcontrib>Cesselin, F.</creatorcontrib><title>Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K
+-evoked CCKLM overflow was reduced by 0.1–10 μM of the μ agonist DAGO or 10 nM to 3 μM of the δ agonist DTLET. By contrast, at a higher concentration (10 μM), the latter drug as well as morphine enhanced CCKLM overflow. Although inactive alone, the κ opioid agonist U 50488 H (1 μM) prevented the inhibitory effect of DAGO without affecting that of DTLET. These data suggest that an opioid acting through the stimulation of μ, δ and κ receptors (such as morphine) should produce a net increase in the spinal release of CCK.</description><subject>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Cholecystokinin - metabolism</subject><subject>Cholecystokinin, In vitro release</subject><subject>DAGO</subject><subject>DTLET</subject><subject>Enkephalin, Ala-MePhe-Gly</subject><subject>Enkephalin, Leucine - analogs & derivatives</subject><subject>Enkephalin, Leucine - pharmacology</subject><subject>Enkephalins - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Narcotic Antagonists</subject><subject>Oligopeptides - pharmacology</subject><subject>Opioid receptor</subject><subject>Pyrrolidines - pharmacology</subject><subject>Rat spinal cord</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Opioid - drug effects</subject><subject>Receptors, Opioid - physiology</subject><subject>Receptors, Opioid, delta</subject><subject>Receptors, Opioid, kappa</subject><subject>Receptors, Opioid, mu</subject><subject>Spinal Cord - metabolism</subject><subject>U 50488 H</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2O1DAQhS0EGpqBG4DkDQgkwvgvcbxBajW_YiQ2sLYcpwyGxA52eqQ-FRtWaM7QZ8KZ7mF2sHLJ9dV7pXoIPaTkBSW0OSOciIorQZ4q-kwRokS1voVWtJWskkqy22j1F7mL7uX8jRBS01qcoBPaiLZRZIV-vvLOQYIwezNgH776zs8x7c7y7MftYJYaj7FfSh8Djg7nyYfCbjYfcIIBTAbc7fD-EpvQ4_0vHCcffY_Nlxh8nvPzq_9cSDv7i8IO0X43PSxS-8uqhwlCX_yvzReXRe93UbcwlQXw9S6ldR_dcWbI8OD4nqLPb15_2ryrzj--fb9Zn1eWcz5XjjvadJbTminSurYzzjrFKVW1lFYwRhrJhAAuoDXMQWeBKmZra50FVit-ip4cdKcUf2whz3r02cIwmABxm3VLmkYxKf8L0iLGG0ELKA6gTTHnBE5PyY8m7TQleglUL2npJS2tqL4KVK_L2KOj_rYbob8ZOiRY-o-PfZOtGVwywfp8gylJZMMX7uWBg3K1Cw9JZ-shWOh9ufOs--j_vcgf4OjDOA</recordid><startdate>19910401</startdate><enddate>19910401</enddate><creator>Benoliel, J.J.</creator><creator>Bourgoin, S.</creator><creator>Mauborgne, A.</creator><creator>Legrand, J.C.</creator><creator>Hamon, M.</creator><creator>Cesselin, F.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910401</creationdate><title>Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation</title><author>Benoliel, J.J. ; Bourgoin, S. ; Mauborgne, A. ; Legrand, J.C. ; Hamon, M. ; Cesselin, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-f3f16bc3152908f8bafcf93119577c422067244e34e8a2febce192c5ccfce2593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cholecystokinin - metabolism</topic><topic>Cholecystokinin, In vitro release</topic><topic>DAGO</topic><topic>DTLET</topic><topic>Enkephalin, Ala-MePhe-Gly</topic><topic>Enkephalin, Leucine - analogs & derivatives</topic><topic>Enkephalin, Leucine - pharmacology</topic><topic>Enkephalins - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Narcotic Antagonists</topic><topic>Oligopeptides - pharmacology</topic><topic>Opioid receptor</topic><topic>Pyrrolidines - pharmacology</topic><topic>Rat spinal cord</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Opioid - drug effects</topic><topic>Receptors, Opioid - physiology</topic><topic>Receptors, Opioid, delta</topic><topic>Receptors, Opioid, kappa</topic><topic>Receptors, Opioid, mu</topic><topic>Spinal Cord - metabolism</topic><topic>U 50488 H</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benoliel, J.J.</creatorcontrib><creatorcontrib>Bourgoin, S.</creatorcontrib><creatorcontrib>Mauborgne, A.</creatorcontrib><creatorcontrib>Legrand, J.C.</creatorcontrib><creatorcontrib>Hamon, M.</creatorcontrib><creatorcontrib>Cesselin, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benoliel, J.J.</au><au>Bourgoin, S.</au><au>Mauborgne, A.</au><au>Legrand, J.C.</au><au>Hamon, M.</au><au>Cesselin, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1991-04-01</date><risdate>1991</risdate><volume>124</volume><issue>2</issue><spage>204</spage><epage>207</epage><pages>204-207</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K
+-evoked CCKLM overflow was reduced by 0.1–10 μM of the μ agonist DAGO or 10 nM to 3 μM of the δ agonist DTLET. By contrast, at a higher concentration (10 μM), the latter drug as well as morphine enhanced CCKLM overflow. Although inactive alone, the κ opioid agonist U 50488 H (1 μM) prevented the inhibitory effect of DAGO without affecting that of DTLET. These data suggest that an opioid acting through the stimulation of μ, δ and κ receptors (such as morphine) should produce a net increase in the spinal release of CCK.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1648690</pmid><doi>10.1016/0304-3940(91)90094-A</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1991-04, Vol.124 (2), p.204-207 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer Analgesics - pharmacology Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Cholecystokinin - metabolism Cholecystokinin, In vitro release DAGO DTLET Enkephalin, Ala-MePhe-Gly Enkephalin, Leucine - analogs & derivatives Enkephalin, Leucine - pharmacology Enkephalins - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Male Narcotic Antagonists Oligopeptides - pharmacology Opioid receptor Pyrrolidines - pharmacology Rat spinal cord Rats Rats, Inbred Strains Receptors, Opioid - drug effects Receptors, Opioid - physiology Receptors, Opioid, delta Receptors, Opioid, kappa Receptors, Opioid, mu Spinal Cord - metabolism U 50488 H Vertebrates: nervous system and sense organs |
| title | Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation |
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