Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients wi...
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| Veröffentlicht in: | The Lancet (British edition) 1991-07, Vol.338 (8761), p.215-216 |
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| container_title | The Lancet (British edition) |
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| creator | Borok, Z. Buhl, R. Hubbard, R.C. Holroyd, K.J. Roum, J.H. Czerski, D.B. Crystal, R.G. Grimes, G.J. Bokser, A.D. Cantin, A.M. |
| description | Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF. |
| doi_str_mv | 10.1016/0140-6736(91)90350-X |
| format | Article |
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Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(91)90350-X</identifier><identifier>PMID: 1676780</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Aerosols ; Antioxidants ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - metabolism ; Drugs ; Female ; Glutathione - administration & dosage ; Glutathione - metabolism ; Humans ; Lungs ; Macrophages - metabolism ; Male ; Medical research ; Medical sciences ; Middle Aged ; Oxidizing agents ; Oxygen - metabolism ; Pharmacology. Drug treatments ; Pulmonary Alveoli - cytology ; Pulmonary Alveoli - metabolism ; Pulmonary Fibrosis - drug therapy ; Pulmonary Fibrosis - metabolism ; Respiratory diseases ; Respiratory system ; Superoxides</subject><ispartof>The Lancet (British edition), 1991-07, Vol.338 (8761), p.215-216</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Jul 27, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-82319d1ffb57b1a3c9a1b8269e7e6389c0fe9f224ea52461e781735c6cb697c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/014067369190350X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27902,27903,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19844620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1676780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borok, Z.</creatorcontrib><creatorcontrib>Buhl, R.</creatorcontrib><creatorcontrib>Hubbard, R.C.</creatorcontrib><creatorcontrib>Holroyd, K.J.</creatorcontrib><creatorcontrib>Roum, J.H.</creatorcontrib><creatorcontrib>Czerski, D.B.</creatorcontrib><creatorcontrib>Crystal, R.G.</creatorcontrib><creatorcontrib>Grimes, G.J.</creatorcontrib><creatorcontrib>Bokser, A.D.</creatorcontrib><creatorcontrib>Cantin, A.M.</creatorcontrib><title>Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.</description><subject>Adult</subject><subject>Aerosols</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - metabolism</subject><subject>Drugs</subject><subject>Female</subject><subject>Glutathione - administration & dosage</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Lungs</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxidizing agents</subject><subject>Oxygen - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Alveoli - cytology</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Pulmonary Fibrosis - drug therapy</subject><subject>Pulmonary Fibrosis - metabolism</subject><subject>Respiratory diseases</subject><subject>Respiratory system</subject><subject>Superoxides</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpSTZJ_0ECotDQHpxqbH1Yl0IJ6QcEemlhb0KWR6mCbW0ku7T_vnJ3aSCHHoQE88zwziNCzoFdAQP5jgFnlVSNfKPhrWaNYNX2GdkAV7wSXG2fk80_5Jic5HzPGOOSiSNyBFJJ1bINMTfeo5tp9PRuWGY7_whxQmoxxRwHGicaf4XeTnNVTji8aRg7O9jJIQ0TDX2Iu7XR0d0yjHGy6Tf1oSsTQj4jL7wdMr483Kfk-8ebb9efq9uvn75cf7itnGhgrtq6Ad2D951QHdjGaQtdW0uNCmXTasc8al_XHK2ouQRULahGOOk6qZXTzSm53M_dpfiwYJ7NGLLDoaTEuGTTMinbmkMBXz0B7-OSppLNgNasFkyoAvE95MoSOaE3uxTGspcBZlb5ZjVrVrNGg_kr32xL28Vh9tKN2D827W2X-utD3WZnB5-KwpAfMd1yLuuVe7_nsBj7GTCZ7AIW3X1I5bNMH8P_g_wBDoChDA</recordid><startdate>19910727</startdate><enddate>19910727</enddate><creator>Borok, Z.</creator><creator>Buhl, R.</creator><creator>Hubbard, R.C.</creator><creator>Holroyd, K.J.</creator><creator>Roum, J.H.</creator><creator>Czerski, D.B.</creator><creator>Crystal, R.G.</creator><creator>Grimes, G.J.</creator><creator>Bokser, A.D.</creator><creator>Cantin, A.M.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19910727</creationdate><title>Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis</title><author>Borok, Z. ; Buhl, R. ; Hubbard, R.C. ; Holroyd, K.J. ; Roum, J.H. ; Czerski, D.B. ; Crystal, R.G. ; Grimes, G.J. ; Bokser, A.D. ; Cantin, A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-82319d1ffb57b1a3c9a1b8269e7e6389c0fe9f224ea52461e781735c6cb697c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aerosols</topic><topic>Antioxidants</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - metabolism</topic><topic>Drugs</topic><topic>Female</topic><topic>Glutathione - administration & dosage</topic><topic>Glutathione - metabolism</topic><topic>Humans</topic><topic>Lungs</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxidizing agents</topic><topic>Oxygen - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Alveoli - cytology</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Pulmonary Fibrosis - drug therapy</topic><topic>Pulmonary Fibrosis - metabolism</topic><topic>Respiratory diseases</topic><topic>Respiratory system</topic><topic>Superoxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borok, Z.</creatorcontrib><creatorcontrib>Buhl, R.</creatorcontrib><creatorcontrib>Hubbard, R.C.</creatorcontrib><creatorcontrib>Holroyd, K.J.</creatorcontrib><creatorcontrib>Roum, J.H.</creatorcontrib><creatorcontrib>Czerski, D.B.</creatorcontrib><creatorcontrib>Crystal, R.G.</creatorcontrib><creatorcontrib>Grimes, G.J.</creatorcontrib><creatorcontrib>Bokser, A.D.</creatorcontrib><creatorcontrib>Cantin, A.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borok, Z.</au><au>Buhl, R.</au><au>Hubbard, R.C.</au><au>Holroyd, K.J.</au><au>Roum, J.H.</au><au>Czerski, D.B.</au><au>Crystal, R.G.</au><au>Grimes, G.J.</au><au>Bokser, A.D.</au><au>Cantin, A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1991-07-27</date><risdate>1991</risdate><volume>338</volume><issue>8761</issue><spage>215</spage><epage>216</epage><pages>215-216</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). 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| ispartof | The Lancet (British edition), 1991-07, Vol.338 (8761), p.215-216 |
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| subjects | Adult Aerosols Antioxidants Biological and medical sciences Bronchoalveolar Lavage Fluid - metabolism Drugs Female Glutathione - administration & dosage Glutathione - metabolism Humans Lungs Macrophages - metabolism Male Medical research Medical sciences Middle Aged Oxidizing agents Oxygen - metabolism Pharmacology. Drug treatments Pulmonary Alveoli - cytology Pulmonary Alveoli - metabolism Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Respiratory diseases Respiratory system Superoxides |
| title | Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis |
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