Severe osteoporosis in a young female patient with Crohn's disease
Increasing pain in the region of the lumbar vertebrae occurred in a 23-year-old woman known for the past 6 1/2 years to have Crohn's disease affecting the ileocolon. Radiology revealed marked osteopenia with collapse and deformation of the vertebral bodies. The only pointer to a bone disease wa...
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| Veröffentlicht in: | Deutsche medizinische Wochenschrift 1991-07, Vol.116 (27), p.1055-1060 |
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| creator | Neef, B Höring, E Maier, K E von Gaisberg, U |
| description | Increasing pain in the region of the lumbar vertebrae occurred in a 23-year-old woman known for the past 6 1/2 years to have Crohn's disease affecting the ileocolon. Radiology revealed marked osteopenia with collapse and deformation of the vertebral bodies. The only pointer to a bone disease was a markedly lowered serum level of 25-OH-vitamin D (less than 10 ng/ml). Biopsy from the ileal crest revealed pure osteoporosis without osteomalacia. Decisive pathogenetic factors were, in the main, glucocorticoid medication, malnutrition and the long duration of Crohn's disease. During treatment with monofluorophosphate, 152 g daily, in fixed combination with 600 mg calcium as well as calcitonin (initially 100 I.U. daily subcutaneously for two weeks, then 100 I.U. every other day s.c.) and vitamin D (3 x 1,000 I.U. daily by mouth) she became free of symptoms, and she has remained so for 9 months. |
| format | Article |
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Radiology revealed marked osteopenia with collapse and deformation of the vertebral bodies. The only pointer to a bone disease was a markedly lowered serum level of 25-OH-vitamin D (less than 10 ng/ml). Biopsy from the ileal crest revealed pure osteoporosis without osteomalacia. Decisive pathogenetic factors were, in the main, glucocorticoid medication, malnutrition and the long duration of Crohn's disease. During treatment with monofluorophosphate, 152 g daily, in fixed combination with 600 mg calcium as well as calcitonin (initially 100 I.U. daily subcutaneously for two weeks, then 100 I.U. every other day s.c.) and vitamin D (3 x 1,000 I.U. daily by mouth) she became free of symptoms, and she has remained so for 9 months.</description><identifier>ISSN: 0012-0472</identifier><identifier>PMID: 1648471</identifier><language>ger</language><publisher>Germany</publisher><subject>Adult ; Biopsy ; Bone Density ; Cholecalciferol - blood ; Combined Modality Therapy ; Crohn Disease - complications ; Crohn Disease - diagnosis ; Crohn Disease - therapy ; Female ; Humans ; Ilium - pathology ; Lumbar Vertebrae - diagnostic imaging ; Osteoporosis - diagnosis ; Osteoporosis - etiology ; Osteoporosis - therapy ; Tomography, X-Ray Computed</subject><ispartof>Deutsche medizinische Wochenschrift, 1991-07, Vol.116 (27), p.1055-1060</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1648471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neef, B</creatorcontrib><creatorcontrib>Höring, E</creatorcontrib><creatorcontrib>Maier, K E</creatorcontrib><creatorcontrib>von Gaisberg, U</creatorcontrib><title>Severe osteoporosis in a young female patient with Crohn's disease</title><title>Deutsche medizinische Wochenschrift</title><addtitle>Dtsch Med Wochenschr</addtitle><description>Increasing pain in the region of the lumbar vertebrae occurred in a 23-year-old woman known for the past 6 1/2 years to have Crohn's disease affecting the ileocolon. Radiology revealed marked osteopenia with collapse and deformation of the vertebral bodies. The only pointer to a bone disease was a markedly lowered serum level of 25-OH-vitamin D (less than 10 ng/ml). Biopsy from the ileal crest revealed pure osteoporosis without osteomalacia. Decisive pathogenetic factors were, in the main, glucocorticoid medication, malnutrition and the long duration of Crohn's disease. During treatment with monofluorophosphate, 152 g daily, in fixed combination with 600 mg calcium as well as calcitonin (initially 100 I.U. daily subcutaneously for two weeks, then 100 I.U. every other day s.c.) and vitamin D (3 x 1,000 I.U. daily by mouth) she became free of symptoms, and she has remained so for 9 months.</description><subject>Adult</subject><subject>Biopsy</subject><subject>Bone Density</subject><subject>Cholecalciferol - blood</subject><subject>Combined Modality Therapy</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - diagnosis</subject><subject>Crohn Disease - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Ilium - pathology</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Osteoporosis - diagnosis</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - therapy</subject><subject>Tomography, X-Ray Computed</subject><issn>0012-0472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj0tLxDAURrNQxnH0JwhZ6aqQx-1rqcUXDLhw9iWd3DiRNqm5rTL_3hG7-jhwOPCdsbUQUmUCSnXBLok-_7DWsGIrWUAFpVyzh3f8xoQ80oRxjCmSJ-4DN_wY5_DBHQ6mRz6ayWOY-I-fDrxJ8RDuiFtPaAiv2LkzPeH1shu2e3rcNS_Z9u35tbnfZmOuZWZq0QmNuS5zsFAUIMCV9d4KkBJFhaA0gHTgcmGLWpS57DSowhmUTiq0esNu_7Njil8z0tQOnvbY9yZgnKmtxCmqZH0SbxZx7ga07Zj8YNKxXT7rX9itUEo</recordid><startdate>19910705</startdate><enddate>19910705</enddate><creator>Neef, B</creator><creator>Höring, E</creator><creator>Maier, K E</creator><creator>von Gaisberg, U</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19910705</creationdate><title>Severe osteoporosis in a young female patient with Crohn's disease</title><author>Neef, B ; Höring, E ; Maier, K E ; von Gaisberg, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p531-a90b03e53754d466404f79cd0411e08e423441f4f50d690751b3426fae1f12ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Biopsy</topic><topic>Bone Density</topic><topic>Cholecalciferol - blood</topic><topic>Combined Modality Therapy</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - diagnosis</topic><topic>Crohn Disease - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Ilium - pathology</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Osteoporosis - diagnosis</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - therapy</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neef, B</creatorcontrib><creatorcontrib>Höring, E</creatorcontrib><creatorcontrib>Maier, K E</creatorcontrib><creatorcontrib>von Gaisberg, U</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Deutsche medizinische Wochenschrift</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neef, B</au><au>Höring, E</au><au>Maier, K E</au><au>von Gaisberg, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe osteoporosis in a young female patient with Crohn's disease</atitle><jtitle>Deutsche medizinische Wochenschrift</jtitle><addtitle>Dtsch Med Wochenschr</addtitle><date>1991-07-05</date><risdate>1991</risdate><volume>116</volume><issue>27</issue><spage>1055</spage><epage>1060</epage><pages>1055-1060</pages><issn>0012-0472</issn><abstract>Increasing pain in the region of the lumbar vertebrae occurred in a 23-year-old woman known for the past 6 1/2 years to have Crohn's disease affecting the ileocolon. Radiology revealed marked osteopenia with collapse and deformation of the vertebral bodies. The only pointer to a bone disease was a markedly lowered serum level of 25-OH-vitamin D (less than 10 ng/ml). Biopsy from the ileal crest revealed pure osteoporosis without osteomalacia. Decisive pathogenetic factors were, in the main, glucocorticoid medication, malnutrition and the long duration of Crohn's disease. During treatment with monofluorophosphate, 152 g daily, in fixed combination with 600 mg calcium as well as calcitonin (initially 100 I.U. daily subcutaneously for two weeks, then 100 I.U. every other day s.c.) and vitamin D (3 x 1,000 I.U. daily by mouth) she became free of symptoms, and she has remained so for 9 months.</abstract><cop>Germany</cop><pmid>1648471</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Deutsche medizinische Wochenschrift, 1991-07, Vol.116 (27), p.1055-1060 |
| issn | 0012-0472 |
| language | ger |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Biopsy Bone Density Cholecalciferol - blood Combined Modality Therapy Crohn Disease - complications Crohn Disease - diagnosis Crohn Disease - therapy Female Humans Ilium - pathology Lumbar Vertebrae - diagnostic imaging Osteoporosis - diagnosis Osteoporosis - etiology Osteoporosis - therapy Tomography, X-Ray Computed |
| title | Severe osteoporosis in a young female patient with Crohn's disease |
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