New regulatory factors for melanogenesis: Developmental changes in neonatal mice of various genotypes
The biosynthesis of melanin occurs through sequential steps known as the Mason-Raper pathway. The initial steps are the conversion of tyrosine to dihydroxyphenylalanine (dopa) and of dopa to dopaquinone by the enzyme tyrosinase (EC 1.10.3.1). Until recently it was assumed that once these first two c...
Gespeichert in:
| Veröffentlicht in: | Developmental biology 1983-01, Vol.100 (1), p.120-126 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 126 |
|---|---|
| container_issue | 1 |
| container_start_page | 120 |
| container_title | Developmental biology |
| container_volume | 100 |
| creator | Murray, Marilyn Pawelek, John M. Lamoreux, M.Lynn |
| description | The biosynthesis of melanin occurs through sequential steps known as the Mason-Raper pathway. The initial steps are the conversion of tyrosine to dihydroxyphenylalanine (dopa) and of dopa to dopaquinone by the enzyme tyrosinase (EC 1.10.3.1). Until recently it was assumed that once these first two conversions were completed, the subsequent reactions occurred spontaneously. However, studies with mouse melanoma cells in culture revealed that subsequent steps in the pathway are also regulated. In this report, we demonstrate that these steps are also regulated in skins of fetal and newborn mice. The specific activities of the regulatory factors change during the first week after birth and differ in mice of different genotypes. The findings provide new insights into genetic and developmental regulation of the pigmentary system in mammals. |
| doi_str_mv | 10.1016/0012-1606(83)90202-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80662960</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0012160683902026</els_id><sourcerecordid>80662960</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-c90b2f1f9e3bc9220756ea1a56617376f67b6a6ef2299c7a6c27f2d13ace7d843</originalsourceid><addsrcrecordid>eNqFkUFvEzEQhS0EKqHwD0DyAaFyWBjbm_GaAxIqlFaq4AISN8vxjoPR7jq1N6ny79klUY7lNNLM955m3jD2UsA7AQLfAwhZCQS8aNRbAxJkhY_YQoBZVkusfz1mixPylD0r5Q8AqKZRZ-wMa6GkFgtG3-ieZ1pvOzemvOfB-akWHlLmPXVuSGsaqMTygX-mHXVp09Mwuo77325YU-Fx4AOlwc29PnriKfCdyzFtC5-kadxvqDxnT4LrCr041nP28-rLj8vr6vb715vLT7eVr4UeK29gJYMIhtTKGylBL5GccEtEoZXGgHqFDilIaYzXDr3UQbZCOU-6bWp1zt4cfDc53W2pjLaPxVM33UHTQrYBRGkQ_gsK1QjQenasD6DPqZRMwW5y7F3eWwF2foOdM7ZzxrZR9t8bLE6yV0f_7aqn9iQ65j7NXx_nrnjXhewGH8sJM7WRNczYxwNGU2i7SNkWH2nw1MZMfrRtig_v8Rd5EqRi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13810774</pqid></control><display><type>article</type><title>New regulatory factors for melanogenesis: Developmental changes in neonatal mice of various genotypes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Murray, Marilyn ; Pawelek, John M. ; Lamoreux, M.Lynn</creator><creatorcontrib>Murray, Marilyn ; Pawelek, John M. ; Lamoreux, M.Lynn</creatorcontrib><description>The biosynthesis of melanin occurs through sequential steps known as the Mason-Raper pathway. The initial steps are the conversion of tyrosine to dihydroxyphenylalanine (dopa) and of dopa to dopaquinone by the enzyme tyrosinase (EC 1.10.3.1). Until recently it was assumed that once these first two conversions were completed, the subsequent reactions occurred spontaneously. However, studies with mouse melanoma cells in culture revealed that subsequent steps in the pathway are also regulated. In this report, we demonstrate that these steps are also regulated in skins of fetal and newborn mice. The specific activities of the regulatory factors change during the first week after birth and differ in mice of different genotypes. The findings provide new insights into genetic and developmental regulation of the pigmentary system in mammals.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/0012-1606(83)90202-6</identifier><identifier>PMID: 6413271</identifier><identifier>CODEN: DEBIAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Albinism - genetics ; Albinism - metabolism ; Animals ; Animals, Newborn - growth & development ; Biological and medical sciences ; Dihydroxyphenylalanine - metabolism ; Embryology: invertebrates and vertebrates. Teratology ; Fundamental and applied biological sciences. Psychology ; Indoles - metabolism ; Melanins - biosynthesis ; Melanins - genetics ; Mice ; Mice, Inbred AKR - genetics ; Mice, Inbred C57BL - genetics ; Organogenesis. Physiological fonctions ; Skin - metabolism ; Tyrosine - metabolism</subject><ispartof>Developmental biology, 1983-01, Vol.100 (1), p.120-126</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c90b2f1f9e3bc9220756ea1a56617376f67b6a6ef2299c7a6c27f2d13ace7d843</citedby><cites>FETCH-LOGICAL-c417t-c90b2f1f9e3bc9220756ea1a56617376f67b6a6ef2299c7a6c27f2d13ace7d843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0012-1606(83)90202-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9492401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6413271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murray, Marilyn</creatorcontrib><creatorcontrib>Pawelek, John M.</creatorcontrib><creatorcontrib>Lamoreux, M.Lynn</creatorcontrib><title>New regulatory factors for melanogenesis: Developmental changes in neonatal mice of various genotypes</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>The biosynthesis of melanin occurs through sequential steps known as the Mason-Raper pathway. The initial steps are the conversion of tyrosine to dihydroxyphenylalanine (dopa) and of dopa to dopaquinone by the enzyme tyrosinase (EC 1.10.3.1). Until recently it was assumed that once these first two conversions were completed, the subsequent reactions occurred spontaneously. However, studies with mouse melanoma cells in culture revealed that subsequent steps in the pathway are also regulated. In this report, we demonstrate that these steps are also regulated in skins of fetal and newborn mice. The specific activities of the regulatory factors change during the first week after birth and differ in mice of different genotypes. The findings provide new insights into genetic and developmental regulation of the pigmentary system in mammals.</description><subject>Albinism - genetics</subject><subject>Albinism - metabolism</subject><subject>Animals</subject><subject>Animals, Newborn - growth & development</subject><subject>Biological and medical sciences</subject><subject>Dihydroxyphenylalanine - metabolism</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Indoles - metabolism</subject><subject>Melanins - biosynthesis</subject><subject>Melanins - genetics</subject><subject>Mice</subject><subject>Mice, Inbred AKR - genetics</subject><subject>Mice, Inbred C57BL - genetics</subject><subject>Organogenesis. Physiological fonctions</subject><subject>Skin - metabolism</subject><subject>Tyrosine - metabolism</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvEzEQhS0EKqHwD0DyAaFyWBjbm_GaAxIqlFaq4AISN8vxjoPR7jq1N6ny79klUY7lNNLM955m3jD2UsA7AQLfAwhZCQS8aNRbAxJkhY_YQoBZVkusfz1mixPylD0r5Q8AqKZRZ-wMa6GkFgtG3-ieZ1pvOzemvOfB-akWHlLmPXVuSGsaqMTygX-mHXVp09Mwuo77325YU-Fx4AOlwc29PnriKfCdyzFtC5-kadxvqDxnT4LrCr041nP28-rLj8vr6vb715vLT7eVr4UeK29gJYMIhtTKGylBL5GccEtEoZXGgHqFDilIaYzXDr3UQbZCOU-6bWp1zt4cfDc53W2pjLaPxVM33UHTQrYBRGkQ_gsK1QjQenasD6DPqZRMwW5y7F3eWwF2foOdM7ZzxrZR9t8bLE6yV0f_7aqn9iQ65j7NXx_nrnjXhewGH8sJM7WRNczYxwNGU2i7SNkWH2nw1MZMfrRtig_v8Rd5EqRi</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Murray, Marilyn</creator><creator>Pawelek, John M.</creator><creator>Lamoreux, M.Lynn</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>New regulatory factors for melanogenesis: Developmental changes in neonatal mice of various genotypes</title><author>Murray, Marilyn ; Pawelek, John M. ; Lamoreux, M.Lynn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c90b2f1f9e3bc9220756ea1a56617376f67b6a6ef2299c7a6c27f2d13ace7d843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Albinism - genetics</topic><topic>Albinism - metabolism</topic><topic>Animals</topic><topic>Animals, Newborn - growth & development</topic><topic>Biological and medical sciences</topic><topic>Dihydroxyphenylalanine - metabolism</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Indoles - metabolism</topic><topic>Melanins - biosynthesis</topic><topic>Melanins - genetics</topic><topic>Mice</topic><topic>Mice, Inbred AKR - genetics</topic><topic>Mice, Inbred C57BL - genetics</topic><topic>Organogenesis. Physiological fonctions</topic><topic>Skin - metabolism</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murray, Marilyn</creatorcontrib><creatorcontrib>Pawelek, John M.</creatorcontrib><creatorcontrib>Lamoreux, M.Lynn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murray, Marilyn</au><au>Pawelek, John M.</au><au>Lamoreux, M.Lynn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New regulatory factors for melanogenesis: Developmental changes in neonatal mice of various genotypes</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>100</volume><issue>1</issue><spage>120</spage><epage>126</epage><pages>120-126</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><coden>DEBIAO</coden><abstract>The biosynthesis of melanin occurs through sequential steps known as the Mason-Raper pathway. The initial steps are the conversion of tyrosine to dihydroxyphenylalanine (dopa) and of dopa to dopaquinone by the enzyme tyrosinase (EC 1.10.3.1). Until recently it was assumed that once these first two conversions were completed, the subsequent reactions occurred spontaneously. However, studies with mouse melanoma cells in culture revealed that subsequent steps in the pathway are also regulated. In this report, we demonstrate that these steps are also regulated in skins of fetal and newborn mice. The specific activities of the regulatory factors change during the first week after birth and differ in mice of different genotypes. The findings provide new insights into genetic and developmental regulation of the pigmentary system in mammals.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6413271</pmid><doi>10.1016/0012-1606(83)90202-6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1606 |
| ispartof | Developmental biology, 1983-01, Vol.100 (1), p.120-126 |
| issn | 0012-1606 1095-564X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80662960 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Albinism - genetics Albinism - metabolism Animals Animals, Newborn - growth & development Biological and medical sciences Dihydroxyphenylalanine - metabolism Embryology: invertebrates and vertebrates. Teratology Fundamental and applied biological sciences. Psychology Indoles - metabolism Melanins - biosynthesis Melanins - genetics Mice Mice, Inbred AKR - genetics Mice, Inbred C57BL - genetics Organogenesis. Physiological fonctions Skin - metabolism Tyrosine - metabolism |
| title | New regulatory factors for melanogenesis: Developmental changes in neonatal mice of various genotypes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A50%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20regulatory%20factors%20for%20melanogenesis:%20Developmental%20changes%20in%20neonatal%20mice%20of%20various%20genotypes&rft.jtitle=Developmental%20biology&rft.au=Murray,%20Marilyn&rft.date=1983-01-01&rft.volume=100&rft.issue=1&rft.spage=120&rft.epage=126&rft.pages=120-126&rft.issn=0012-1606&rft.eissn=1095-564X&rft.coden=DEBIAO&rft_id=info:doi/10.1016/0012-1606(83)90202-6&rft_dat=%3Cproquest_cross%3E80662960%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13810774&rft_id=info:pmid/6413271&rft_els_id=0012160683902026&rfr_iscdi=true |