Differing characteristics of human papillomavirus rna‐positive and rna‐negative anal carcinomas
Anal carcinomas were tested for the presence of human papillomavirus (HPV) RNA transcripts by in situ hybridization using 125I‐labeled RNA probes. The HPV transcripts were detected in 73.2% of 41 nonglandular anal carcinomas but in none of six anal or 11 rectal adenocarcinomas. In anal nonglandular...
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| Veröffentlicht in: | Cancer 1991-08, Vol.68 (3), p.561-567 |
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| creator | Higgins, Geoffrey D. Uzelin, Diana M. Burrell, Christopher J. Phillips, Gael E. Pieterse, Arnoldus S. |
| description | Anal carcinomas were tested for the presence of human papillomavirus (HPV) RNA transcripts by in situ hybridization using 125I‐labeled RNA probes. The HPV transcripts were detected in 73.2% of 41 nonglandular anal carcinomas but in none of six anal or 11 rectal adenocarcinomas. In anal nonglandular carcinomas, no difference in the percentage of tumors that were HPV RNA positive was observed between tumors classed as basaloid carcinomas or squamous cell carcinomas. Patients with HPV RNA‐negative tumors were significantly older (9.2 years) than those with HPV RNA‐positive tumors. Anal intraepithelial neoplasia Grade 3 in the surrounding epithelium was seen in 14 of 25 assessable HPV RNA‐positive tumors and in none of nine assessable HPV RNA‐negative tumors. Anal tumors may include two separate clinical and biologic groups distinguished by their dependence, or lack of dependence, on HPV RNA expression for maintenance of the neoplastic state. |
| doi_str_mv | 10.1002/1097-0142(19910801)68:3<561::AID-CNCR2820680320>3.0.CO;2-R |
| format | Article |
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The HPV transcripts were detected in 73.2% of 41 nonglandular anal carcinomas but in none of six anal or 11 rectal adenocarcinomas. In anal nonglandular carcinomas, no difference in the percentage of tumors that were HPV RNA positive was observed between tumors classed as basaloid carcinomas or squamous cell carcinomas. Patients with HPV RNA‐negative tumors were significantly older (9.2 years) than those with HPV RNA‐positive tumors. Anal intraepithelial neoplasia Grade 3 in the surrounding epithelium was seen in 14 of 25 assessable HPV RNA‐positive tumors and in none of nine assessable HPV RNA‐negative tumors. Anal tumors may include two separate clinical and biologic groups distinguished by their dependence, or lack of dependence, on HPV RNA expression for maintenance of the neoplastic state.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19910801)68:3<561::AID-CNCR2820680320>3.0.CO;2-R</identifier><identifier>PMID: 1648434</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - microbiology ; Aged ; Anus Neoplasms - microbiology ; Anus Neoplasms - pathology ; Carcinoma, Squamous Cell - microbiology ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Transitional Cell - metabolism ; Carcinoma, Transitional Cell - pathology ; Epithelium - pathology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Nucleic Acid Hybridization ; Papillomaviridae - genetics ; Rectal Neoplasms - microbiology ; RNA Probes ; RNA, Viral - analysis ; Tumor Virus Infections</subject><ispartof>Cancer, 1991-08, Vol.68 (3), p.561-567</ispartof><rights>Copyright © 1991 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4660-b4a82de7c0aead06f1f5354386a5e942a940d2b68ae9dc231a7bd42c0c38c3943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1648434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higgins, Geoffrey D.</creatorcontrib><creatorcontrib>Uzelin, Diana M.</creatorcontrib><creatorcontrib>Burrell, Christopher J.</creatorcontrib><creatorcontrib>Phillips, Gael E.</creatorcontrib><creatorcontrib>Pieterse, Arnoldus S.</creatorcontrib><title>Differing characteristics of human papillomavirus rna‐positive and rna‐negative anal carcinomas</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Anal carcinomas were tested for the presence of human papillomavirus (HPV) RNA transcripts by in situ hybridization using 125I‐labeled RNA probes. The HPV transcripts were detected in 73.2% of 41 nonglandular anal carcinomas but in none of six anal or 11 rectal adenocarcinomas. In anal nonglandular carcinomas, no difference in the percentage of tumors that were HPV RNA positive was observed between tumors classed as basaloid carcinomas or squamous cell carcinomas. Patients with HPV RNA‐negative tumors were significantly older (9.2 years) than those with HPV RNA‐positive tumors. Anal intraepithelial neoplasia Grade 3 in the surrounding epithelium was seen in 14 of 25 assessable HPV RNA‐positive tumors and in none of nine assessable HPV RNA‐negative tumors. Anal tumors may include two separate clinical and biologic groups distinguished by their dependence, or lack of dependence, on HPV RNA expression for maintenance of the neoplastic state.</description><subject>Adenocarcinoma - microbiology</subject><subject>Aged</subject><subject>Anus Neoplasms - microbiology</subject><subject>Anus Neoplasms - pathology</subject><subject>Carcinoma, Squamous Cell - microbiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Transitional Cell - metabolism</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Nucleic Acid Hybridization</subject><subject>Papillomaviridae - genetics</subject><subject>Rectal Neoplasms - microbiology</subject><subject>RNA Probes</subject><subject>RNA, Viral - analysis</subject><subject>Tumor Virus Infections</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUdtqFEEQbYKSrEk-ITBPQR9mrb5MT88ahDiJGgguLAbEl6a2pyfpMDe7dyJ58xP8xnyJvewa0QchT0XVqTqnOIeQdxSmFIC9plDkKVDBXtKioKCAvpJqxk8ySWez04uztPxULphiIBVwBm_5FKbl_A1LFztk8nj8jEwAQKWZ4F_2yIsQbmObs4zvkl0qhRJcTIg5c3VtveuuE3ODHs0qNmHlTEj6OrkZW-ySAQfXNH2Ld86PIfEdPvz4OfTBrdydTbCrtqPOXuN2hE1i0BvXxatwQJ7X2AR7uK375Or9-efyY3o5_3BRnl6mRkgJ6VKgYpXNDaDFCmRN64zH55XEzBaCYSGgYkup0BaVYZxivqwEM2C4MrwQfJ8cb3gH338bbVjp1gVjmwY7249BK5CS5pTFxa-bReP7ELyt9eBdi_5eU9DrBPTaRL02Uf9OQEuluY4JaB0T0H8nEBHQ5VwzvYjkR9svxmVrqz_UG8sjbjf4d9fY-ycp_1f4H4T_Am-0pw0</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Higgins, Geoffrey D.</creator><creator>Uzelin, Diana M.</creator><creator>Burrell, Christopher J.</creator><creator>Phillips, Gael E.</creator><creator>Pieterse, Arnoldus S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910801</creationdate><title>Differing characteristics of human papillomavirus rna‐positive and rna‐negative anal carcinomas</title><author>Higgins, Geoffrey D. ; Uzelin, Diana M. ; Burrell, Christopher J. ; Phillips, Gael E. ; Pieterse, Arnoldus S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4660-b4a82de7c0aead06f1f5354386a5e942a940d2b68ae9dc231a7bd42c0c38c3943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenocarcinoma - microbiology</topic><topic>Aged</topic><topic>Anus Neoplasms - microbiology</topic><topic>Anus Neoplasms - pathology</topic><topic>Carcinoma, Squamous Cell - microbiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Transitional Cell - metabolism</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Nucleic Acid Hybridization</topic><topic>Papillomaviridae - genetics</topic><topic>Rectal Neoplasms - microbiology</topic><topic>RNA Probes</topic><topic>RNA, Viral - analysis</topic><topic>Tumor Virus Infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higgins, Geoffrey D.</creatorcontrib><creatorcontrib>Uzelin, Diana M.</creatorcontrib><creatorcontrib>Burrell, Christopher J.</creatorcontrib><creatorcontrib>Phillips, Gael E.</creatorcontrib><creatorcontrib>Pieterse, Arnoldus S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higgins, Geoffrey D.</au><au>Uzelin, Diana M.</au><au>Burrell, Christopher J.</au><au>Phillips, Gael E.</au><au>Pieterse, Arnoldus S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differing characteristics of human papillomavirus rna‐positive and rna‐negative anal carcinomas</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>68</volume><issue>3</issue><spage>561</spage><epage>567</epage><pages>561-567</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Anal carcinomas were tested for the presence of human papillomavirus (HPV) RNA transcripts by in situ hybridization using 125I‐labeled RNA probes. The HPV transcripts were detected in 73.2% of 41 nonglandular anal carcinomas but in none of six anal or 11 rectal adenocarcinomas. In anal nonglandular carcinomas, no difference in the percentage of tumors that were HPV RNA positive was observed between tumors classed as basaloid carcinomas or squamous cell carcinomas. Patients with HPV RNA‐negative tumors were significantly older (9.2 years) than those with HPV RNA‐positive tumors. Anal intraepithelial neoplasia Grade 3 in the surrounding epithelium was seen in 14 of 25 assessable HPV RNA‐positive tumors and in none of nine assessable HPV RNA‐negative tumors. Anal tumors may include two separate clinical and biologic groups distinguished by their dependence, or lack of dependence, on HPV RNA expression for maintenance of the neoplastic state.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1648434</pmid><doi>10.1002/1097-0142(19910801)68:3<561::AID-CNCR2820680320>3.0.CO;2-R</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - microbiology Aged Anus Neoplasms - microbiology Anus Neoplasms - pathology Carcinoma, Squamous Cell - microbiology Carcinoma, Squamous Cell - pathology Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology Epithelium - pathology Female Humans Male Middle Aged Neoplasm Invasiveness Nucleic Acid Hybridization Papillomaviridae - genetics Rectal Neoplasms - microbiology RNA Probes RNA, Viral - analysis Tumor Virus Infections |
| title | Differing characteristics of human papillomavirus rna‐positive and rna‐negative anal carcinomas |
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