Thy-1 antigen is specific to ganglion cells in chicks
The cellular localization of Thy-1 in the chick retina was investigated by selectively destroying certain populations of neurons with toxins. In control retinae four weeks after intravitreal injection of vehicle, there was strong immunoreactivity for Thy-1 in the nerve fibre layer, ganglion cell lay...
Gespeichert in:
| Veröffentlicht in: | Neuroscience letters 1991-02, Vol.123 (1), p.87-90 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | 1 |
| container_start_page | 87 |
| container_title | Neuroscience letters |
| container_volume | 123 |
| creator | Sheppard, Allan M. Konopka, Michael Robinson, Stephen R. Morgan, Ian G. Jeffrey, Peter L. |
| description | The cellular localization of Thy-1 in the chick retina was investigated by selectively destroying certain populations of neurons with toxins. In control retinae four weeks after intravitreal injection of vehicle, there was strong immunoreactivity for Thy-1 in the nerve fibre layer, ganglion cell layer and inner plexiform layer. By contrast, 4 weeks after intraocular injection with 1.25 nmol of colchicine, virtually all ganglion cells had been destroyed, but most amacrine cells remained. Very little Thy-1 immunoreactivity was evident in these retinae. Four weeks after intraocular injection of 2 μmol of
N-
methyl-
d-aspartic acid
(NMDA), a large proportion of amacrine cells had been destroyed, but most ganglion cells remained. In these retinae Thy-1 immunoreactivity was present in the nerve fibre, ganglion cell and inner plexiform layers, in the latter with greater intensity than in controls. We conclude that in chicks the Thy-1 antigen is principally, if not exclusively, restricted to ganglion cells. |
| doi_str_mv | 10.1016/0304-3940(91)90164-O |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80659604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>030439409190164O</els_id><sourcerecordid>15896328</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-1058187f7c766e6024867b3277c2e0286441a0fcec4eddbc83eefc768d0b94ec3</originalsourceid><addsrcrecordid>eNqFkE1Lw0AQhhdRtFb_gUIuih6is8lmPy6CFL9A6EXPy3YyqatpUrOp0H_v1hZ709MMM88MLw9jJxyuOHB5DTmINDcCLgy_NHEi0vEOG3CtslQZle2ywS9ywA5DeAeAghdin-1zqWQBMGDFy9sy5Ylrej-lJvEhCXNCX3lM-jaZumZa-7ZJkOo6JD42bx4_whHbq1wd6HhTh-z1_u5l9Jg-jx-eRrfPKQqu-5RDoWOcSqGSkiRkQks1yTOlMCPItBSCO6iQUFBZTlDnRFVkdQkTIwjzITtf_5137eeCQm9nPqyyuIbaRbAaZGEkiH9BXmgj80xHUKxB7NoQOqrsvPMz1y0tB7vSalfO7MqZNdz-aLXjeHa6-b-YzKjcHq09xv3ZZu8CurrqXIM-bDEjZQ4mj9zNmqNo7ctTZwN6apBK3xH2tmz930G-AQnckX4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15896328</pqid></control><display><type>article</type><title>Thy-1 antigen is specific to ganglion cells in chicks</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Sheppard, Allan M. ; Konopka, Michael ; Robinson, Stephen R. ; Morgan, Ian G. ; Jeffrey, Peter L.</creator><creatorcontrib>Sheppard, Allan M. ; Konopka, Michael ; Robinson, Stephen R. ; Morgan, Ian G. ; Jeffrey, Peter L.</creatorcontrib><description>The cellular localization of Thy-1 in the chick retina was investigated by selectively destroying certain populations of neurons with toxins. In control retinae four weeks after intravitreal injection of vehicle, there was strong immunoreactivity for Thy-1 in the nerve fibre layer, ganglion cell layer and inner plexiform layer. By contrast, 4 weeks after intraocular injection with 1.25 nmol of colchicine, virtually all ganglion cells had been destroyed, but most amacrine cells remained. Very little Thy-1 immunoreactivity was evident in these retinae. Four weeks after intraocular injection of 2 μmol of
N-
methyl-
d-aspartic acid
(NMDA), a large proportion of amacrine cells had been destroyed, but most ganglion cells remained. In these retinae Thy-1 immunoreactivity was present in the nerve fibre, ganglion cell and inner plexiform layers, in the latter with greater intensity than in controls. We conclude that in chicks the Thy-1 antigen is principally, if not exclusively, restricted to ganglion cells.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(91)90164-O</identifier><identifier>PMID: 1676500</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Amacrine cell ; Animals ; Antigens, Surface - analysis ; Biological and medical sciences ; Chickens ; Colchicine ; Colchicine - pharmacology ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fundamental and applied biological sciences. Psychology ; Ganglion cell ; Immunoenzyme Techniques ; Male ; N-Methylaspartate - pharmacology ; Nerve Fibers - drug effects ; Nerve Fibers - immunology ; Nerve Fibers - ultrastructure ; NMDA ; Retina - cytology ; Retina - drug effects ; Retina - immunology ; Retinal Ganglion Cells - cytology ; Retinal Ganglion Cells - drug effects ; Retinal Ganglion Cells - immunology ; Thy-1 Antigens ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1991-02, Vol.123 (1), p.87-90</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-1058187f7c766e6024867b3277c2e0286441a0fcec4eddbc83eefc768d0b94ec3</citedby><cites>FETCH-LOGICAL-c418t-1058187f7c766e6024867b3277c2e0286441a0fcec4eddbc83eefc768d0b94ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(91)90164-O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19663093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1676500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheppard, Allan M.</creatorcontrib><creatorcontrib>Konopka, Michael</creatorcontrib><creatorcontrib>Robinson, Stephen R.</creatorcontrib><creatorcontrib>Morgan, Ian G.</creatorcontrib><creatorcontrib>Jeffrey, Peter L.</creatorcontrib><title>Thy-1 antigen is specific to ganglion cells in chicks</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The cellular localization of Thy-1 in the chick retina was investigated by selectively destroying certain populations of neurons with toxins. In control retinae four weeks after intravitreal injection of vehicle, there was strong immunoreactivity for Thy-1 in the nerve fibre layer, ganglion cell layer and inner plexiform layer. By contrast, 4 weeks after intraocular injection with 1.25 nmol of colchicine, virtually all ganglion cells had been destroyed, but most amacrine cells remained. Very little Thy-1 immunoreactivity was evident in these retinae. Four weeks after intraocular injection of 2 μmol of
N-
methyl-
d-aspartic acid
(NMDA), a large proportion of amacrine cells had been destroyed, but most ganglion cells remained. In these retinae Thy-1 immunoreactivity was present in the nerve fibre, ganglion cell and inner plexiform layers, in the latter with greater intensity than in controls. We conclude that in chicks the Thy-1 antigen is principally, if not exclusively, restricted to ganglion cells.</description><subject>Amacrine cell</subject><subject>Animals</subject><subject>Antigens, Surface - analysis</subject><subject>Biological and medical sciences</subject><subject>Chickens</subject><subject>Colchicine</subject><subject>Colchicine - pharmacology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglion cell</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>N-Methylaspartate - pharmacology</subject><subject>Nerve Fibers - drug effects</subject><subject>Nerve Fibers - immunology</subject><subject>Nerve Fibers - ultrastructure</subject><subject>NMDA</subject><subject>Retina - cytology</subject><subject>Retina - drug effects</subject><subject>Retina - immunology</subject><subject>Retinal Ganglion Cells - cytology</subject><subject>Retinal Ganglion Cells - drug effects</subject><subject>Retinal Ganglion Cells - immunology</subject><subject>Thy-1 Antigens</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRtFb_gUIuih6is8lmPy6CFL9A6EXPy3YyqatpUrOp0H_v1hZ709MMM88MLw9jJxyuOHB5DTmINDcCLgy_NHEi0vEOG3CtslQZle2ywS9ywA5DeAeAghdin-1zqWQBMGDFy9sy5Ylrej-lJvEhCXNCX3lM-jaZumZa-7ZJkOo6JD42bx4_whHbq1wd6HhTh-z1_u5l9Jg-jx-eRrfPKQqu-5RDoWOcSqGSkiRkQks1yTOlMCPItBSCO6iQUFBZTlDnRFVkdQkTIwjzITtf_5137eeCQm9nPqyyuIbaRbAaZGEkiH9BXmgj80xHUKxB7NoQOqrsvPMz1y0tB7vSalfO7MqZNdz-aLXjeHa6-b-YzKjcHq09xv3ZZu8CurrqXIM-bDEjZQ4mj9zNmqNo7ctTZwN6apBK3xH2tmz930G-AQnckX4</recordid><startdate>19910211</startdate><enddate>19910211</enddate><creator>Sheppard, Allan M.</creator><creator>Konopka, Michael</creator><creator>Robinson, Stephen R.</creator><creator>Morgan, Ian G.</creator><creator>Jeffrey, Peter L.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910211</creationdate><title>Thy-1 antigen is specific to ganglion cells in chicks</title><author>Sheppard, Allan M. ; Konopka, Michael ; Robinson, Stephen R. ; Morgan, Ian G. ; Jeffrey, Peter L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-1058187f7c766e6024867b3277c2e0286441a0fcec4eddbc83eefc768d0b94ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amacrine cell</topic><topic>Animals</topic><topic>Antigens, Surface - analysis</topic><topic>Biological and medical sciences</topic><topic>Chickens</topic><topic>Colchicine</topic><topic>Colchicine - pharmacology</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglion cell</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Nerve Fibers - drug effects</topic><topic>Nerve Fibers - immunology</topic><topic>Nerve Fibers - ultrastructure</topic><topic>NMDA</topic><topic>Retina - cytology</topic><topic>Retina - drug effects</topic><topic>Retina - immunology</topic><topic>Retinal Ganglion Cells - cytology</topic><topic>Retinal Ganglion Cells - drug effects</topic><topic>Retinal Ganglion Cells - immunology</topic><topic>Thy-1 Antigens</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheppard, Allan M.</creatorcontrib><creatorcontrib>Konopka, Michael</creatorcontrib><creatorcontrib>Robinson, Stephen R.</creatorcontrib><creatorcontrib>Morgan, Ian G.</creatorcontrib><creatorcontrib>Jeffrey, Peter L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheppard, Allan M.</au><au>Konopka, Michael</au><au>Robinson, Stephen R.</au><au>Morgan, Ian G.</au><au>Jeffrey, Peter L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thy-1 antigen is specific to ganglion cells in chicks</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1991-02-11</date><risdate>1991</risdate><volume>123</volume><issue>1</issue><spage>87</spage><epage>90</epage><pages>87-90</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The cellular localization of Thy-1 in the chick retina was investigated by selectively destroying certain populations of neurons with toxins. In control retinae four weeks after intravitreal injection of vehicle, there was strong immunoreactivity for Thy-1 in the nerve fibre layer, ganglion cell layer and inner plexiform layer. By contrast, 4 weeks after intraocular injection with 1.25 nmol of colchicine, virtually all ganglion cells had been destroyed, but most amacrine cells remained. Very little Thy-1 immunoreactivity was evident in these retinae. Four weeks after intraocular injection of 2 μmol of
N-
methyl-
d-aspartic acid
(NMDA), a large proportion of amacrine cells had been destroyed, but most ganglion cells remained. In these retinae Thy-1 immunoreactivity was present in the nerve fibre, ganglion cell and inner plexiform layers, in the latter with greater intensity than in controls. We conclude that in chicks the Thy-1 antigen is principally, if not exclusively, restricted to ganglion cells.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1676500</pmid><doi>10.1016/0304-3940(91)90164-O</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1991-02, Vol.123 (1), p.87-90 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80659604 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amacrine cell Animals Antigens, Surface - analysis Biological and medical sciences Chickens Colchicine Colchicine - pharmacology Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Ganglion cell Immunoenzyme Techniques Male N-Methylaspartate - pharmacology Nerve Fibers - drug effects Nerve Fibers - immunology Nerve Fibers - ultrastructure NMDA Retina - cytology Retina - drug effects Retina - immunology Retinal Ganglion Cells - cytology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - immunology Thy-1 Antigens Vertebrates: nervous system and sense organs |
| title | Thy-1 antigen is specific to ganglion cells in chicks |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T09%3A19%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thy-1%20antigen%20is%20specific%20to%20ganglion%20cells%20in%20chicks&rft.jtitle=Neuroscience%20letters&rft.au=Sheppard,%20Allan%20M.&rft.date=1991-02-11&rft.volume=123&rft.issue=1&rft.spage=87&rft.epage=90&rft.pages=87-90&rft.issn=0304-3940&rft.eissn=1872-7972&rft.coden=NELED5&rft_id=info:doi/10.1016/0304-3940(91)90164-O&rft_dat=%3Cproquest_cross%3E15896328%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15896328&rft_id=info:pmid/1676500&rft_els_id=030439409190164O&rfr_iscdi=true |