Nonspecific cytotoxic cells of rainbow trout ( Oncorhynchus mykiss) kill YAC-1 targets by both necrotic and apoptic mechanisms

Nonspecific cytotoxic cells (NCC) have been identified in a number of fish species and are thought to be evolutionary progenitors of mammalian natural killer cells. We show here that trout NCC are functionally similar to cytotoxic cells of higher vertebrates in that they mediate cytotoxicity through...

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Veröffentlicht in:	Developmental and comparative immunology 1991, Vol.15 (3), p.153-164
Hauptverfasser:	Greenlee, Anne R., Brown, Ruth A., Ristow, Sandra S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Brackish Cellular apoptosis Cellular necrosis Chromium release assay Cytotoxic mechanisms of trout NCC Cytotoxicity, Immunologic - drug effects DNA fragmentation assay Female Freshwater Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology In Vitro Techniques Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - ultrastructure Male Mannose-6-phosphate inhibition of NCC Mannosephosphates - pharmacology Marine NCC morphology Necrosis Oncorhynchus mykiss Organs and cells involved in the immune response Phagocytosis - drug effects Salmon - immunology Tumor Cells, Cultured - immunology
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