Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVI. Effect of Probenecid on Plasma Protein Binding of Sulfadimethoxine in Fast and Slow Acetylator Rabbits

Two groups of rabbits categorized on the basis of their acetylation capacity were used in this study as fast and slow acetylator rabbits. The ratio of the unbound fraction of sulfadimethoxine (SDM) in plasma at 2 h after intravenous bolus injection of SDM in combination with probenecid to the unboun...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1983/05/25, Vol.31(5), pp.1768-1771
Hauptverfasser:	IMAMURA, YORISHIGE, MORI, HIROYUKI, ICHIBAGASE, HISASHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blood Proteins - metabolism Male Medical sciences Pharmacology. Drug treatments Phenotype plasma concentration Probenecid - pharmacology Protein Binding - drug effects Rabbits Sulfadimethoxine - blood
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