Corticotropin deficiency: A rare cause of hyponatremia mimicking siadh
We describe 2 patients presenting with severe chronic hyponatremia in whom clinical and biochemical features strongly suggested the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Both, however, were proven to have a primary pituitary deficiency of corticotropin. Their short synact...
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| Veröffentlicht in: | Pathology 1991, Vol.23 (1), p.8-10 |
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| container_title | Pathology |
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| creator | De Leacy, Eric A. Bowler, Simon Brown, Jennifer M. Cowley, David M. |
| description | We describe 2 patients presenting with severe chronic hyponatremia in whom clinical and biochemical features strongly suggested the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Both, however, were proven to have a primary pituitary deficiency of corticotropin. Their short synacthen tests were only mildly abnormal but associated with low basal ACTH levels. The diagnosis of ACTH deficiency was made more convincingly by their dramatic response to glucocorticoid replacement therapy. In patients in whom no cause for SIADH can be found, a trial of maintenance Cortisol therapy is warranted to exclude this eminently treatable condition. |
| doi_str_mv | 10.3109/00313029109061431 |
| format | Article |
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Both, however, were proven to have a primary pituitary deficiency of corticotropin. Their short synacthen tests were only mildly abnormal but associated with low basal ACTH levels. The diagnosis of ACTH deficiency was made more convincingly by their dramatic response to glucocorticoid replacement therapy. In patients in whom no cause for SIADH can be found, a trial of maintenance Cortisol therapy is warranted to exclude this eminently treatable condition.</description><identifier>ISSN: 0031-3025</identifier><identifier>EISSN: 1465-3931</identifier><identifier>DOI: 10.3109/00313029109061431</identifier><identifier>PMID: 1648196</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adrenocorticotropic Hormone - deficiency ; Aged ; corticotropin deficiency ; Cortisone - analogs & derivatives ; Cortisone - therapeutic use ; Diagnosis, Differential ; empty sella ; Female ; Humans ; Hyponatremia ; Hyponatremia - diagnosis ; Hyponatremia - etiology ; hypopituitarism ; Inappropriate ADH Syndrome - diagnosis ; Male ; Middle Aged</subject><ispartof>Pathology, 1991, Vol.23 (1), p.8-10</ispartof><rights>1991 Royal College of Pathologists of Australasia</rights><rights>1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-de34b51ac7fa6a4134490e9e8de8b18353fb0358dd6d5c56f433252d826987013</citedby><cites>FETCH-LOGICAL-c429t-de34b51ac7fa6a4134490e9e8de8b18353fb0358dd6d5c56f433252d826987013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00313029109061431$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00313029109061431$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,61194,61375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1648196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Leacy, Eric A.</creatorcontrib><creatorcontrib>Bowler, Simon</creatorcontrib><creatorcontrib>Brown, Jennifer M.</creatorcontrib><creatorcontrib>Cowley, David M.</creatorcontrib><title>Corticotropin deficiency: A rare cause of hyponatremia mimicking siadh</title><title>Pathology</title><addtitle>Pathology</addtitle><description>We describe 2 patients presenting with severe chronic hyponatremia in whom clinical and biochemical features strongly suggested the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Both, however, were proven to have a primary pituitary deficiency of corticotropin. Their short synacthen tests were only mildly abnormal but associated with low basal ACTH levels. The diagnosis of ACTH deficiency was made more convincingly by their dramatic response to glucocorticoid replacement therapy. In patients in whom no cause for SIADH can be found, a trial of maintenance Cortisol therapy is warranted to exclude this eminently treatable condition.</description><subject>Adrenocorticotropic Hormone - deficiency</subject><subject>Aged</subject><subject>corticotropin deficiency</subject><subject>Cortisone - analogs & derivatives</subject><subject>Cortisone - therapeutic use</subject><subject>Diagnosis, Differential</subject><subject>empty sella</subject><subject>Female</subject><subject>Humans</subject><subject>Hyponatremia</subject><subject>Hyponatremia - diagnosis</subject><subject>Hyponatremia - etiology</subject><subject>hypopituitarism</subject><subject>Inappropriate ADH Syndrome - diagnosis</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6AzwIPXmrJs3HpnpaFr9gwYueQ5pMbda2WZNW2H9v1y54EPY0A-88L8yD0CXBN5Tg_BZjSijO8mHHgjBKjtCUMMFTmlNyjKa7PB0O-Ck6i3GNMWZSygmaEMEkycUUPS596JzxXfAb1yYWSmcctGZ7lyySoAMkRvcREl8m1XbjW90FaJxOGtc48-najyQ6batzdFLqOsLFfs7Q--PD2_I5Xb0-vSwXq9SwLO9SC5QVnGgzL7XQjFDGcgw5SAuyIJJyWhaYcmmtsNxwUTJKM55ZmYlczjGhM3Q99m6C_-ohdqpx0UBd6xZ8H5XEgov5YGKGyHhogo8xQKk2wTU6bBXBaudO_XM3MFf78r5owP4Ro6whvx9z15Y-NLoCXXeVGSSpte9DOzx-sH1Pw-Dn20FQ8dc0WBfAdMp6d4D-AQCLjR0</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>De Leacy, Eric A.</creator><creator>Bowler, Simon</creator><creator>Brown, Jennifer M.</creator><creator>Cowley, David M.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Corticotropin deficiency: A rare cause of hyponatremia mimicking siadh</title><author>De Leacy, Eric A. ; Bowler, Simon ; Brown, Jennifer M. ; Cowley, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-de34b51ac7fa6a4134490e9e8de8b18353fb0358dd6d5c56f433252d826987013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adrenocorticotropic Hormone - deficiency</topic><topic>Aged</topic><topic>corticotropin deficiency</topic><topic>Cortisone - analogs & derivatives</topic><topic>Cortisone - therapeutic use</topic><topic>Diagnosis, Differential</topic><topic>empty sella</topic><topic>Female</topic><topic>Humans</topic><topic>Hyponatremia</topic><topic>Hyponatremia - diagnosis</topic><topic>Hyponatremia - etiology</topic><topic>hypopituitarism</topic><topic>Inappropriate ADH Syndrome - diagnosis</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Leacy, Eric A.</creatorcontrib><creatorcontrib>Bowler, Simon</creatorcontrib><creatorcontrib>Brown, Jennifer M.</creatorcontrib><creatorcontrib>Cowley, David M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Leacy, Eric A.</au><au>Bowler, Simon</au><au>Brown, Jennifer M.</au><au>Cowley, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticotropin deficiency: A rare cause of hyponatremia mimicking siadh</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>1991</date><risdate>1991</risdate><volume>23</volume><issue>1</issue><spage>8</spage><epage>10</epage><pages>8-10</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>We describe 2 patients presenting with severe chronic hyponatremia in whom clinical and biochemical features strongly suggested the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Both, however, were proven to have a primary pituitary deficiency of corticotropin. Their short synacthen tests were only mildly abnormal but associated with low basal ACTH levels. The diagnosis of ACTH deficiency was made more convincingly by their dramatic response to glucocorticoid replacement therapy. In patients in whom no cause for SIADH can be found, a trial of maintenance Cortisol therapy is warranted to exclude this eminently treatable condition.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>1648196</pmid><doi>10.3109/00313029109061431</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3025 |
| ispartof | Pathology, 1991, Vol.23 (1), p.8-10 |
| issn | 0031-3025 1465-3931 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete; Alma/SFX Local Collection |
| subjects | Adrenocorticotropic Hormone - deficiency Aged corticotropin deficiency Cortisone - analogs & derivatives Cortisone - therapeutic use Diagnosis, Differential empty sella Female Humans Hyponatremia Hyponatremia - diagnosis Hyponatremia - etiology hypopituitarism Inappropriate ADH Syndrome - diagnosis Male Middle Aged |
| title | Corticotropin deficiency: A rare cause of hyponatremia mimicking siadh |
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