Cellular immune response of a marsupial, Monodelphis domestica
Marsupials are interesting subjects for studies of comparative and developmental immunology because they separated from eutherian mammals over 100 million years ago and because the newborns are still in a fetal state. We studied cellular immunity in a fully pedigreed colony of the marsupial, M. dome...
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| Veröffentlicht in: | Developmental and comparative immunology 1991, Vol.15 (3), p.189-199 |
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| container_title | Developmental and comparative immunology |
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| creator | Infante, Anthony J. Samples, Nancy K. Croix, Denise A. Redding, Todd S. VandeBerg, John L. Stone, William H. |
| description | Marsupials are interesting subjects for studies of comparative and developmental immunology because they separated from eutherian mammals over 100 million years ago and because the newborns are still in a fetal state. We studied cellular immunity in a fully pedigreed colony of the marsupial,
M. domestica (commonly called the gray short-tailed opossum). Peripheral blood lymphocytes were separated on nylon wool columns into adherent cells bearing surface immunoglobulin (B cells) and nonadherent cells (T cells) recovered in the ratio of 1:3. Peripheral blood lymphocytes responded by proliferation to Con A and other mitogens. Nonadherent cells were responsive to Con A, but adherent cells were not. Peripheral blood lymphocytes were stimulated weakly or not at all by allogeneic or xenogeneic (mouse) cells in mixed lymphocyte culture. Despite the weak MLC response, which was not due to genetic homogeneity, allogeneic and xenogeneic tail skin grafts were rejected promptly. These data suggest that the cellular immune response of
M. domestica is similar to that of eutherian mammals with the notable exception of weak MLC responses |
| doi_str_mv | 10.1016/0145-305X(91)90010-V |
| format | Article |
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M. domestica (commonly called the gray short-tailed opossum). Peripheral blood lymphocytes were separated on nylon wool columns into adherent cells bearing surface immunoglobulin (B cells) and nonadherent cells (T cells) recovered in the ratio of 1:3. Peripheral blood lymphocytes responded by proliferation to Con A and other mitogens. Nonadherent cells were responsive to Con A, but adherent cells were not. Peripheral blood lymphocytes were stimulated weakly or not at all by allogeneic or xenogeneic (mouse) cells in mixed lymphocyte culture. Despite the weak MLC response, which was not due to genetic homogeneity, allogeneic and xenogeneic tail skin grafts were rejected promptly. These data suggest that the cellular immune response of
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M. domestica (commonly called the gray short-tailed opossum). Peripheral blood lymphocytes were separated on nylon wool columns into adherent cells bearing surface immunoglobulin (B cells) and nonadherent cells (T cells) recovered in the ratio of 1:3. Peripheral blood lymphocytes responded by proliferation to Con A and other mitogens. Nonadherent cells were responsive to Con A, but adherent cells were not. Peripheral blood lymphocytes were stimulated weakly or not at all by allogeneic or xenogeneic (mouse) cells in mixed lymphocyte culture. Despite the weak MLC response, which was not due to genetic homogeneity, allogeneic and xenogeneic tail skin grafts were rejected promptly. These data suggest that the cellular immune response of
M. domestica is similar to that of eutherian mammals with the notable exception of weak MLC responses</description><subject>Allografts</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Comparative immunity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunity, Cellular</subject><subject>Immunobiology</subject><subject>In Vitro Techniques</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>MHC</subject><subject>Mitogens - pharmacology</subject><subject>Mixed lymphocyte reaction</subject><subject>Monodelphis domestica</subject><subject>Opossums - immunology</subject><subject>Organs and cells involved in the immune response</subject><subject>Phylogeny</subject><subject>Skin Transplantation - immunology</subject><subject>T-Lymphocytes - immunology</subject><issn>0145-305X</issn><issn>1879-0089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVoSTdp_kEKPpSQQp3O7Fq2dAmUpY9AQi5tyE2MpTFRsS1XWgfy76vNLumtncsc5pvXJ8QpwgUC1p8AK1muQN6fa_ygARDKuwOxQNXoEkDpV2LxgrwRRyn9ghwK4VAcolrqCvVCXK657-eeYuGHYR65iJymMCYuQldQMVBM8-Sp_1jchDE47qcHnwoXBk4bb-mteN1Rn_hkn4_Fz69ffqy_l9e3367Wn69LW2GzKdF2bFd62Vjp5LKrHVlwTFA3jXR1VWvtFNHKsetIN52yKLFtW9dSXQFpWB2Ls93cKYbfc95tBp9sPp1GDnMyCmopZSX_C6JUSipsMljtQBtDSpE7M0Wf330yCGbr12zlma08o9E8-zV3ue3dfv7cDuz-Nu2E5vr7fZ2Spb6LNFqfXrBKN0uJdcYudxhnaY-eo0nW82jZ-ch2Y1zw_77jD4QYl24</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Infante, Anthony J.</creator><creator>Samples, Nancy K.</creator><creator>Croix, Denise A.</creator><creator>Redding, Todd S.</creator><creator>VandeBerg, John L.</creator><creator>Stone, William H.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Cellular immune response of a marsupial, Monodelphis domestica</title><author>Infante, Anthony J. ; Samples, Nancy K. ; Croix, Denise A. ; Redding, Todd S. ; VandeBerg, John L. ; Stone, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1cfec3927c5d52f6dac0dea06775d64699d8aa3dedfa97f8c151bbbdba640a903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Allografts</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Comparative immunity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunity, Cellular</topic><topic>Immunobiology</topic><topic>In Vitro Techniques</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>MHC</topic><topic>Mitogens - pharmacology</topic><topic>Mixed lymphocyte reaction</topic><topic>Monodelphis domestica</topic><topic>Opossums - immunology</topic><topic>Organs and cells involved in the immune response</topic><topic>Phylogeny</topic><topic>Skin Transplantation - immunology</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Infante, Anthony J.</creatorcontrib><creatorcontrib>Samples, Nancy K.</creatorcontrib><creatorcontrib>Croix, Denise A.</creatorcontrib><creatorcontrib>Redding, Todd S.</creatorcontrib><creatorcontrib>VandeBerg, John L.</creatorcontrib><creatorcontrib>Stone, William H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental and comparative immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Infante, Anthony J.</au><au>Samples, Nancy K.</au><au>Croix, Denise A.</au><au>Redding, Todd S.</au><au>VandeBerg, John L.</au><au>Stone, William H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular immune response of a marsupial, Monodelphis domestica</atitle><jtitle>Developmental and comparative immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>1991</date><risdate>1991</risdate><volume>15</volume><issue>3</issue><spage>189</spage><epage>199</epage><pages>189-199</pages><issn>0145-305X</issn><eissn>1879-0089</eissn><coden>DCIMDQ</coden><abstract>Marsupials are interesting subjects for studies of comparative and developmental immunology because they separated from eutherian mammals over 100 million years ago and because the newborns are still in a fetal state. We studied cellular immunity in a fully pedigreed colony of the marsupial,
M. domestica (commonly called the gray short-tailed opossum). Peripheral blood lymphocytes were separated on nylon wool columns into adherent cells bearing surface immunoglobulin (B cells) and nonadherent cells (T cells) recovered in the ratio of 1:3. Peripheral blood lymphocytes responded by proliferation to Con A and other mitogens. Nonadherent cells were responsive to Con A, but adherent cells were not. Peripheral blood lymphocytes were stimulated weakly or not at all by allogeneic or xenogeneic (mouse) cells in mixed lymphocyte culture. Despite the weak MLC response, which was not due to genetic homogeneity, allogeneic and xenogeneic tail skin grafts were rejected promptly. These data suggest that the cellular immune response of
M. domestica is similar to that of eutherian mammals with the notable exception of weak MLC responses</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1829419</pmid><doi>10.1016/0145-305X(91)90010-V</doi><tpages>11</tpages></addata></record> |
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| ispartof | Developmental and comparative immunology, 1991, Vol.15 (3), p.189-199 |
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| language | eng |
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| subjects | Allografts Analysis of the immune response. Humoral and cellular immunity Animals B-Lymphocytes - immunology Biological and medical sciences Comparative immunity Fundamental and applied biological sciences. Psychology Fundamental immunology Immunity, Cellular Immunobiology In Vitro Techniques Lymphocyte Activation Lymphocyte Culture Test, Mixed MHC Mitogens - pharmacology Mixed lymphocyte reaction Monodelphis domestica Opossums - immunology Organs and cells involved in the immune response Phylogeny Skin Transplantation - immunology T-Lymphocytes - immunology |
| title | Cellular immune response of a marsupial, Monodelphis domestica |
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