Effects of estrogen on the excitability of neurons projecting from the noradrenergic A1 region to the preoptic and anterior hypothalamic area
Estradiol benzoate administered to ovariectomized female rats significantly elevated the mean spontaneous firing rate and frequency of successful antidromic propagation into the somatodendritic spike and significantly reduced the strength of post-stimulus inhibition in presumed A1 noradrenergic neur...
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| Veröffentlicht in: | Brain research 1983-09, Vol.274 (1), p.156-159 |
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| container_title | Brain research |
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| creator | Kaba, Hideto Saito, Hideo Otsuka, Kuniaki Seto, Katsuo Kawakami, Masazumi |
| description | Estradiol benzoate administered to ovariectomized female rats significantly elevated the mean spontaneous firing rate and frequency of successful antidromic propagation into the somatodendritic spike and significantly reduced the strength of post-stimulus inhibition in presumed A1 noradrenergic neurons projecting directly to the preoptic and anterior hypothalamic area. The occurrence of both antidromic spikes and post-stimulus inhibition of the majority of these neurons was completely abolished by the injection of 6-hydroxydopamine but not by 5, 7-dihydroxytryptamine directly into the medial forebrain bundle. |
| doi_str_mv | 10.1016/0006-8993(83)90532-2 |
| format | Article |
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The occurrence of both antidromic spikes and post-stimulus inhibition of the majority of these neurons was completely abolished by the injection of 6-hydroxydopamine but not by 5, 7-dihydroxytryptamine directly into the medial forebrain bundle.</description><subject>5,7-Dihydroxytryptamine - pharmacology</subject><subject>6-hydroxydopamine</subject><subject>A1 noradrenergic neurons</subject><subject>Animals</subject><subject>Anterior Hypothalamic Nucleus - physiology</subject><subject>Castration</subject><subject>Estradiol - pharmacology</subject><subject>estrogen</subject><subject>Female</subject><subject>Hydroxydopamines - pharmacology</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Norepinephrine - metabolism</subject><subject>Oxidopamine</subject><subject>post-stimulus inhibition</subject><subject>Preoptic Area - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>spike dissociation</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFDEYx4Moda1-A4WcxB5G8zbZzEUopdVCoZd6Dpnkmd2UmWRMssX9EH5nM7tLj_YQwsP_JTz5IfSRkq-UUPmNECIb1XX8i-IXHWk5a9grtKJqzRrJBHmNVs-Wt-hdzo915LwjZ-hMCso62a7Q3-thAFsyjgOGXFLcQMAx4LIFDH-sL6b3oy_7RQ-wSzFkPKf4WDM-bPCQ4nTwhpiMSxAgbbzFlxQn2PilJx7kOUGcS1VMcPUUSD4mvN3PsWzNaKZFSWDeozeDGTN8ON3n6NfN9cPVz-bu_sft1eVdY0UrSqOMBGqBOqCst0O37gUFkIIL3kNL1oy4gTJjZR2MZY5RZUlPhXOs7Z3h_Bx9PvbWVX7v6t568tnCOJoAcZe1IrIVTKoXjZRLJQlbjOJotCnmnGDQc_KTSXtNiV5w6YWFXlhoxfUBl2Y19unUv-sncM-hE5-qfz_qUH_jyUPS2XoIFpxPFYF20f__gX9P06c7</recordid><startdate>19830905</startdate><enddate>19830905</enddate><creator>Kaba, Hideto</creator><creator>Saito, Hideo</creator><creator>Otsuka, Kuniaki</creator><creator>Seto, Katsuo</creator><creator>Kawakami, Masazumi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19830905</creationdate><title>Effects of estrogen on the excitability of neurons projecting from the noradrenergic A1 region to the preoptic and anterior hypothalamic area</title><author>Kaba, Hideto ; Saito, Hideo ; Otsuka, Kuniaki ; Seto, Katsuo ; Kawakami, Masazumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-8a6e1ce1de12bcf97b41ee64343be50720df12ac6e50ac2d218c0b14dd25bda33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>5,7-Dihydroxytryptamine - pharmacology</topic><topic>6-hydroxydopamine</topic><topic>A1 noradrenergic neurons</topic><topic>Animals</topic><topic>Anterior Hypothalamic Nucleus - physiology</topic><topic>Castration</topic><topic>Estradiol - pharmacology</topic><topic>estrogen</topic><topic>Female</topic><topic>Hydroxydopamines - pharmacology</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Norepinephrine - metabolism</topic><topic>Oxidopamine</topic><topic>post-stimulus inhibition</topic><topic>Preoptic Area - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>spike dissociation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaba, Hideto</creatorcontrib><creatorcontrib>Saito, Hideo</creatorcontrib><creatorcontrib>Otsuka, Kuniaki</creatorcontrib><creatorcontrib>Seto, Katsuo</creatorcontrib><creatorcontrib>Kawakami, Masazumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaba, Hideto</au><au>Saito, Hideo</au><au>Otsuka, Kuniaki</au><au>Seto, Katsuo</au><au>Kawakami, Masazumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of estrogen on the excitability of neurons projecting from the noradrenergic A1 region to the preoptic and anterior hypothalamic area</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1983-09-05</date><risdate>1983</risdate><volume>274</volume><issue>1</issue><spage>156</spage><epage>159</epage><pages>156-159</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Estradiol benzoate administered to ovariectomized female rats significantly elevated the mean spontaneous firing rate and frequency of successful antidromic propagation into the somatodendritic spike and significantly reduced the strength of post-stimulus inhibition in presumed A1 noradrenergic neurons projecting directly to the preoptic and anterior hypothalamic area. 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| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1983-09, Vol.274 (1), p.156-159 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 5,7-Dihydroxytryptamine - pharmacology 6-hydroxydopamine A1 noradrenergic neurons Animals Anterior Hypothalamic Nucleus - physiology Castration Estradiol - pharmacology estrogen Female Hydroxydopamines - pharmacology Neurons - drug effects Neurons - physiology Norepinephrine - metabolism Oxidopamine post-stimulus inhibition Preoptic Area - physiology Rats Rats, Inbred Strains spike dissociation |
| title | Effects of estrogen on the excitability of neurons projecting from the noradrenergic A1 region to the preoptic and anterior hypothalamic area |
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