Inhibition of ornithine decarboxylase in human fibroblast cells by type I and type II interferons
Dilution of human fibroblast GM2767 cell cultures into fresh serum-containing growth medium induces ornithine decarboxylase activity 45-fold over a six-hour interval. When the fibroblast cultures are supplemented with human fibroblast α-, β-, or γ-interferon at the time of dilution into fresh growth...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1983-08, Vol.114 (3), p.950-954 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Sekar, Vaithilingam Atmar, Valerie J. Joshi, Arati R. Krim, Mathilde Kuehn, Glenn D. |
| description | Dilution of human fibroblast GM2767 cell cultures into fresh serum-containing growth medium induces ornithine decarboxylase activity 45-fold over a six-hour interval. When the fibroblast cultures are supplemented with human fibroblast α-, β-, or γ-interferon at the time of dilution into fresh growth medium, the induction of ornithine decarboxylase is inhibited 61%, 90%, and 65%, respectively. β-Interferon is the most effective type of interferon to inhibit induction of ornithine decarboxylase. |
| doi_str_mv | 10.1016/0006-291X(83)90652-6 |
| format | Article |
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| ispartof | Biochemical and biophysical research communications, 1983-08, Vol.114 (3), p.950-954 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Carboxy-Lyases - antagonists & inhibitors Cells, Cultured Enzyme Induction - drug effects Humans Interferon Type I - pharmacology Interferon-gamma - pharmacology Ornithine Decarboxylase Inhibitors |
| title | Inhibition of ornithine decarboxylase in human fibroblast cells by type I and type II interferons |
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