Calcium channel blockers and behavioral sensitization
Behavioral sensitization to amphetamine-induced stereotypy was previously shown to consist of two separable phenomena, induction and expression, both of which involve the excitatory amino acids (EAA). In the present experiments, the calcium channel blockers (CCB), nifedipine, diltiazem and verapamil...
Gespeichert in:
| Veröffentlicht in: | Life sciences (1973) 1991, Vol.49 (2), p.165-170 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 170 |
|---|---|
| container_issue | 2 |
| container_start_page | 165 |
| container_title | Life sciences (1973) |
| container_volume | 49 |
| creator | Karler, Ralph Turkanis, Stuart A. Partlow, Lester M. Calder, Larry D. |
| description | Behavioral sensitization to amphetamine-induced stereotypy was previously shown to consist of two separable phenomena, induction and expression, both of which involve the excitatory amino acids (EAA). In the present experiments, the calcium channel blockers (CCB), nifedipine, diltiazem and verapamil, were shown to block both phenomena; these results are similar to those reported earlier for DNQX, an antagonist of the
non-N-
methyl-
d-
aspartate
receptors for the EAA. The CCB, like DNQX, affect only that percentage of the stereotypic response which results from the sensitization reaction, without affecting the quantitative portion of the response attributable to the acute effect of amphetamine. The results support previous conclusions that the sensitization response consists of two quantitative components, only one of which involves the EAA. The antagonism exhibited by the CCB suggests that behavioral sensitization involves Ca
++ and L-type calcium channels. |
| doi_str_mv | 10.1016/0024-3205(91)90029-B |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80652096</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>002432059190029B</els_id><sourcerecordid>80652096</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-a4e8c2f14b90505b1680326ca1992b96e0fffa3e1fcc5c029fde848a056650b83</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMo67r6DxR6ENFDdZI22eYiuItfsOBFzyFNJ2y0265Ju6C_3tYte9TTMMwzw7wPIacUrilQcQPA0jhhwC8lvZJdJ-PZHhnTbCpjEAndJ-MdckiOQngHAM6nyYiMGAhGp2xM-FyXxrWryCx1VWEZ5WVtPtCHSFdFlONSb1ztdRkFrIJr3LduXF0dkwOry4AnQ52Qt4f71_lTvHh5fJ7fLWKTymkT6xQzwyxNcwkceE5FBgkTRlMpWS4FgrVWJ0itMdx0AWyBWZpp4EJwyLNkQi62d9e-_mwxNGrlgsGy1BXWbVAZCM5Ain9ByqXs0B5Mt6DxdQgerVp7t9L-S1FQvVbVO1O9MyWp-tWqZt3a2XC_zVdY7JYGj938fJjrYHRpva6MCzuM0z530mG3Www7aRuHXgXjsDJYOI-mUUXt_v7jBzxikiI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15996526</pqid></control><display><type>article</type><title>Calcium channel blockers and behavioral sensitization</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Karler, Ralph ; Turkanis, Stuart A. ; Partlow, Lester M. ; Calder, Larry D.</creator><creatorcontrib>Karler, Ralph ; Turkanis, Stuart A. ; Partlow, Lester M. ; Calder, Larry D.</creatorcontrib><description>Behavioral sensitization to amphetamine-induced stereotypy was previously shown to consist of two separable phenomena, induction and expression, both of which involve the excitatory amino acids (EAA). In the present experiments, the calcium channel blockers (CCB), nifedipine, diltiazem and verapamil, were shown to block both phenomena; these results are similar to those reported earlier for DNQX, an antagonist of the
non-N-
methyl-
d-
aspartate
receptors for the EAA. The CCB, like DNQX, affect only that percentage of the stereotypic response which results from the sensitization reaction, without affecting the quantitative portion of the response attributable to the acute effect of amphetamine. The results support previous conclusions that the sensitization response consists of two quantitative components, only one of which involves the EAA. The antagonism exhibited by the CCB suggests that behavioral sensitization involves Ca
++ and L-type calcium channels.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(91)90029-B</identifier><identifier>PMID: 2062172</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Amphetamine - antagonists & inhibitors ; Animals ; Biological and medical sciences ; Calcium Channel Blockers - pharmacology ; Diltiazem - pharmacology ; Haloperidol - pharmacology ; Male ; Medical sciences ; Mice ; Miscellaneous ; Neuropharmacology ; Nifedipine - pharmacology ; Pharmacology. Drug treatments ; Stereotyped Behavior - drug effects ; Verapamil - pharmacology</subject><ispartof>Life sciences (1973), 1991, Vol.49 (2), p.165-170</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-a4e8c2f14b90505b1680326ca1992b96e0fffa3e1fcc5c029fde848a056650b83</citedby><cites>FETCH-LOGICAL-c497t-a4e8c2f14b90505b1680326ca1992b96e0fffa3e1fcc5c029fde848a056650b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(91)90029-B$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5103263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2062172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karler, Ralph</creatorcontrib><creatorcontrib>Turkanis, Stuart A.</creatorcontrib><creatorcontrib>Partlow, Lester M.</creatorcontrib><creatorcontrib>Calder, Larry D.</creatorcontrib><title>Calcium channel blockers and behavioral sensitization</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Behavioral sensitization to amphetamine-induced stereotypy was previously shown to consist of two separable phenomena, induction and expression, both of which involve the excitatory amino acids (EAA). In the present experiments, the calcium channel blockers (CCB), nifedipine, diltiazem and verapamil, were shown to block both phenomena; these results are similar to those reported earlier for DNQX, an antagonist of the
non-N-
methyl-
d-
aspartate
receptors for the EAA. The CCB, like DNQX, affect only that percentage of the stereotypic response which results from the sensitization reaction, without affecting the quantitative portion of the response attributable to the acute effect of amphetamine. The results support previous conclusions that the sensitization response consists of two quantitative components, only one of which involves the EAA. The antagonism exhibited by the CCB suggests that behavioral sensitization involves Ca
++ and L-type calcium channels.</description><subject>Amphetamine - antagonists & inhibitors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Diltiazem - pharmacology</subject><subject>Haloperidol - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Nifedipine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Stereotyped Behavior - drug effects</subject><subject>Verapamil - pharmacology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6DxR6ENFDdZI22eYiuItfsOBFzyFNJ2y0265Ju6C_3tYte9TTMMwzw7wPIacUrilQcQPA0jhhwC8lvZJdJ-PZHhnTbCpjEAndJ-MdckiOQngHAM6nyYiMGAhGp2xM-FyXxrWryCx1VWEZ5WVtPtCHSFdFlONSb1ztdRkFrIJr3LduXF0dkwOry4AnQ52Qt4f71_lTvHh5fJ7fLWKTymkT6xQzwyxNcwkceE5FBgkTRlMpWS4FgrVWJ0itMdx0AWyBWZpp4EJwyLNkQi62d9e-_mwxNGrlgsGy1BXWbVAZCM5Ain9ByqXs0B5Mt6DxdQgerVp7t9L-S1FQvVbVO1O9MyWp-tWqZt3a2XC_zVdY7JYGj938fJjrYHRpva6MCzuM0z530mG3Www7aRuHXgXjsDJYOI-mUUXt_v7jBzxikiI</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Karler, Ralph</creator><creator>Turkanis, Stuart A.</creator><creator>Partlow, Lester M.</creator><creator>Calder, Larry D.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Calcium channel blockers and behavioral sensitization</title><author>Karler, Ralph ; Turkanis, Stuart A. ; Partlow, Lester M. ; Calder, Larry D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-a4e8c2f14b90505b1680326ca1992b96e0fffa3e1fcc5c029fde848a056650b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amphetamine - antagonists & inhibitors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Diltiazem - pharmacology</topic><topic>Haloperidol - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Nifedipine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Stereotyped Behavior - drug effects</topic><topic>Verapamil - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karler, Ralph</creatorcontrib><creatorcontrib>Turkanis, Stuart A.</creatorcontrib><creatorcontrib>Partlow, Lester M.</creatorcontrib><creatorcontrib>Calder, Larry D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karler, Ralph</au><au>Turkanis, Stuart A.</au><au>Partlow, Lester M.</au><au>Calder, Larry D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium channel blockers and behavioral sensitization</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1991</date><risdate>1991</risdate><volume>49</volume><issue>2</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Behavioral sensitization to amphetamine-induced stereotypy was previously shown to consist of two separable phenomena, induction and expression, both of which involve the excitatory amino acids (EAA). In the present experiments, the calcium channel blockers (CCB), nifedipine, diltiazem and verapamil, were shown to block both phenomena; these results are similar to those reported earlier for DNQX, an antagonist of the
non-N-
methyl-
d-
aspartate
receptors for the EAA. The CCB, like DNQX, affect only that percentage of the stereotypic response which results from the sensitization reaction, without affecting the quantitative portion of the response attributable to the acute effect of amphetamine. The results support previous conclusions that the sensitization response consists of two quantitative components, only one of which involves the EAA. The antagonism exhibited by the CCB suggests that behavioral sensitization involves Ca
++ and L-type calcium channels.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2062172</pmid><doi>10.1016/0024-3205(91)90029-B</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1991, Vol.49 (2), p.165-170 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80652096 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amphetamine - antagonists & inhibitors Animals Biological and medical sciences Calcium Channel Blockers - pharmacology Diltiazem - pharmacology Haloperidol - pharmacology Male Medical sciences Mice Miscellaneous Neuropharmacology Nifedipine - pharmacology Pharmacology. Drug treatments Stereotyped Behavior - drug effects Verapamil - pharmacology |
| title | Calcium channel blockers and behavioral sensitization |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T22%3A02%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Calcium%20channel%20blockers%20and%20behavioral%20sensitization&rft.jtitle=Life%20sciences%20(1973)&rft.au=Karler,%20Ralph&rft.date=1991&rft.volume=49&rft.issue=2&rft.spage=165&rft.epage=170&rft.pages=165-170&rft.issn=0024-3205&rft.eissn=1879-0631&rft.coden=LIFSAK&rft_id=info:doi/10.1016/0024-3205(91)90029-B&rft_dat=%3Cproquest_cross%3E80652096%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15996526&rft_id=info:pmid/2062172&rft_els_id=002432059190029B&rfr_iscdi=true |