Oversensitivity to serotonin of the collateralized vascular bed in rat hindquarters: mechanisms of increased vasoconstriction

A buffered solution was perfused at a constant flow rate (2 ml/min) through both iliac arteries in rat hindquarters. Perfusion pressures were measured in normal and collateralized vascular beds of the left and right hind-leg, respectively. Bolus injections of various agonists produced concentration-...

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Veröffentlicht in:	European journal of pharmacology 1991-03, Vol.194 (2), p.209-216
Hauptverfasser:	Verheyen, Alfons, Lauwers, Freddie, Vlaminckx, Eddy, Wouters, Luc, de Clerck, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Collateral Circulation - drug effects Collateral Circulation - physiology Fundamental and applied biological sciences. Psychology Hemodynamics. Rheology Hindlimb - blood supply Hindquarter (rat) Male Perfusion Perfusion (in situ) Rats Rats, Inbred Strains Sensitivity Serotonin - pharmacology Serotonin Antagonists Vasconstriction Vascular bed (collateralized) Vasoconstriction - drug effects Vasoconstriction - physiology Vertebrates: cardiovascular system Vessel structure
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