Actions of n-Alcohols on Nicotinic Acetylcholine Receptor Ion Channels in Cultured Rat Muscle Cells

The effects of the n-alcohols from pentanol to dodecanol on nAChR channel function were resolved at the single channel level. ACh-activated channel activity was recorded from isolated membrane patches using the patch clamp method. The intermediate-chain alcohols (C5-C8) had two main effects: (1) The...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1991-01, Vol.625 (1), p.365-373
Hauptverfasser:	MURRELL, RUTH D., HAYDON, D. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - pharmacology Animals Cells, Cultured Dose-Response Relationship, Drug Ion Channel Gating - drug effects Ion Channels - drug effects Ion Channels - physiology Kinetics Membrane Potentials - drug effects Muscles - physiology Rats Receptors, Nicotinic - drug effects Receptors, Nicotinic - physiology Structure-Activity Relationship
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