Tumor-Derived Growth Factor Increases Bone Resorption in a Tumor Associated with Humoral Hypercalcemia of Malignancy

Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplant...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1983-09, Vol.221 (4617), p.1292-1294
Hauptverfasser:	Ibbotson, K. J., D'Souza, S. M., Ng, K. W., Osborne, C. K., Niall, M., Martin, T. J., Mundy, G. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Biological and medical sciences Bone diseases Bone Resorption Bones Calcium Cell culture techniques Cells, Cultured Culture Media Cultured tumor cells Growth Substances - physiology Host-tumor relations. Immunology. Biological markers Hypercalcemia Hypercalcemia - etiology Leydig Cell Tumor - complications Leydig Cell Tumor - physiopathology Leydig cell tumors Male Medical sciences Neoplasm Proteins - physiology Neoplasms, Experimental - complications Neoplasms, Experimental - physiopathology Neurons Peptides - physiology Rats Receptors Transforming Growth Factors Tumors
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