Strain Differences in Rat Brain Epinephrine Synthesis: Regulation of α-adrenergic Receptor Number by Epinephrine
Inbred rat strains Fischer 344 (F344) and Buffalo (BUF) differ in several physiological and behavioral measures. It was found that the activity of adrenomedullary and regional brain phenylethanolamine N-methyltransferase is at least four times higher in F344 rats than in BUF rats: these strain-depen...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1983-09, Vol.221 (4617), p.1297-1299 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Perry, Bruce D. Stolk, Jon M. Vantini, Guido Guchhait, Ras B. David C. U'Prichard |
| description | Inbred rat strains Fischer 344 (F344) and Buffalo (BUF) differ in several physiological and behavioral measures. It was found that the activity of adrenomedullary and regional brain phenylethanolamine N-methyltransferase is at least four times higher in F344 rats than in BUF rats: these strain-dependent differences corresponded directly with the epinephrine content of the medulla-pons and hypothalamus. Conversely, α-adrenergic receptor density in brain regions containing phenylethanolamine N-methyltransferase is two to three times lower in F344 rats than in BUF rats, α-receptors in frontal cortex (a brain region laking phenylethanolamine N-methyltransferase activity and epinephrine) are similar in both strains. These findings suggest that strain-dependent differences in α-receptors are regulated by inherited differences in presynaptic adrenergic neuronal function in different brain regions. |
| doi_str_mv | 10.1126/science.6310752 |
| format | Article |
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U'Prichard</creator><creatorcontrib>Perry, Bruce D. ; Stolk, Jon M. ; Vantini, Guido ; Guchhait, Ras B. ; David C. U'Prichard</creatorcontrib><description>Inbred rat strains Fischer 344 (F344) and Buffalo (BUF) differ in several physiological and behavioral measures. It was found that the activity of adrenomedullary and regional brain phenylethanolamine N-methyltransferase is at least four times higher in F344 rats than in BUF rats: these strain-dependent differences corresponded directly with the epinephrine content of the medulla-pons and hypothalamus. Conversely, α-adrenergic receptor density in brain regions containing phenylethanolamine N-methyltransferase is two to three times lower in F344 rats than in BUF rats, α-receptors in frontal cortex (a brain region laking phenylethanolamine N-methyltransferase activity and epinephrine) are similar in both strains. These findings suggest that strain-dependent differences in α-receptors are regulated by inherited differences in presynaptic adrenergic neuronal function in different brain regions.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6310752</identifier><identifier>PMID: 6310752</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Adrenal Medulla - enzymology ; Adrenergics ; Animals ; Biological and medical sciences ; Brain ; Brain - metabolism ; Catecholamines ; Cell Membrane - metabolism ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebral Cortex - enzymology ; Epinephrine - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression regulation ; Hypothalamus - enzymology ; Inbred strains ; Inbreeding ; Medulla Oblongata - enzymology ; Neurons ; Norepinephrine ; Phenylethanolamine N-Methyltransferase - metabolism ; Pons - enzymology ; Rats ; Rats, Inbred Strains - metabolism ; Receptors ; Receptors, Adrenergic - metabolism ; Receptors, Adrenergic, alpha - metabolism ; Species Specificity ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 1983-09, Vol.221 (4617), p.1297-1299</ispartof><rights>Copyright 1983 The American Association for the Advancement of Science</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-5a4bf5415153df13a6e9078ea96262038a7435fbde892c28a189359e02851f5d3</citedby><cites>FETCH-LOGICAL-c373t-5a4bf5415153df13a6e9078ea96262038a7435fbde892c28a189359e02851f5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1691700$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1691700$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9351997$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6310752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perry, Bruce D.</creatorcontrib><creatorcontrib>Stolk, Jon M.</creatorcontrib><creatorcontrib>Vantini, Guido</creatorcontrib><creatorcontrib>Guchhait, Ras B.</creatorcontrib><creatorcontrib>David C. U'Prichard</creatorcontrib><title>Strain Differences in Rat Brain Epinephrine Synthesis: Regulation of α-adrenergic Receptor Number by Epinephrine</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Inbred rat strains Fischer 344 (F344) and Buffalo (BUF) differ in several physiological and behavioral measures. It was found that the activity of adrenomedullary and regional brain phenylethanolamine N-methyltransferase is at least four times higher in F344 rats than in BUF rats: these strain-dependent differences corresponded directly with the epinephrine content of the medulla-pons and hypothalamus. Conversely, α-adrenergic receptor density in brain regions containing phenylethanolamine N-methyltransferase is two to three times lower in F344 rats than in BUF rats, α-receptors in frontal cortex (a brain region laking phenylethanolamine N-methyltransferase activity and epinephrine) are similar in both strains. These findings suggest that strain-dependent differences in α-receptors are regulated by inherited differences in presynaptic adrenergic neuronal function in different brain regions.</description><subject>Adrenal Medulla - enzymology</subject><subject>Adrenergics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Catecholamines</subject><subject>Cell Membrane - metabolism</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebral Cortex - enzymology</subject><subject>Epinephrine - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression regulation</subject><subject>Hypothalamus - enzymology</subject><subject>Inbred strains</subject><subject>Inbreeding</subject><subject>Medulla Oblongata - enzymology</subject><subject>Neurons</subject><subject>Norepinephrine</subject><subject>Phenylethanolamine N-Methyltransferase - metabolism</subject><subject>Pons - enzymology</subject><subject>Rats</subject><subject>Rats, Inbred Strains - metabolism</subject><subject>Receptors</subject><subject>Receptors, Adrenergic - metabolism</subject><subject>Receptors, Adrenergic, alpha - metabolism</subject><subject>Species Specificity</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU9PwyAchonRzDk9e9GEg_HWDcpoized80-yaLLpuaH0h7J0bQftYR_LL-JnkrnGeYGQ5-EFXhA6p2RIaRiNnDJQKhhGjJKYhweoT4nggQgJO0R9QlgUJB4coxPnloR4JlgP9Tq9j9aLxkpT4nujNdhtlMN-OZcNvvsF09qUUH9aP-LFpmw-wRl3g-fw0RayMVWJK42_vwKZ-91gP4zyTEHdVBa_tKsMLM42_1NO0ZGWhYOzbh6g94fp2-QpmL0-Pk9uZ4FiMWsCLseZ5mPKKWe5pkxGIEicgBRRGPnXJTIeM66zHBIRqjCRNBGMCyBhwqnmORug611ubat1C65JV8YpKApZQtW6NCHRmDFKvTjaicpWzlnQaW3NStpNSkm6LTntSk671vyOyy66zVaQ__l7ftVx6ZQstJWlMu5P8_ekQsReu9hpS-fb2p8aCRr7n_sB6aSQQA</recordid><startdate>19830923</startdate><enddate>19830923</enddate><creator>Perry, Bruce D.</creator><creator>Stolk, Jon M.</creator><creator>Vantini, Guido</creator><creator>Guchhait, Ras B.</creator><creator>David C. U'Prichard</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830923</creationdate><title>Strain Differences in Rat Brain Epinephrine Synthesis: Regulation of α-adrenergic Receptor Number by Epinephrine</title><author>Perry, Bruce D. ; Stolk, Jon M. ; Vantini, Guido ; Guchhait, Ras B. ; David C. U'Prichard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-5a4bf5415153df13a6e9078ea96262038a7435fbde892c28a189359e02851f5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adrenal Medulla - enzymology</topic><topic>Adrenergics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Catecholamines</topic><topic>Cell Membrane - metabolism</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Cerebral Cortex - enzymology</topic><topic>Epinephrine - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression regulation</topic><topic>Hypothalamus - enzymology</topic><topic>Inbred strains</topic><topic>Inbreeding</topic><topic>Medulla Oblongata - enzymology</topic><topic>Neurons</topic><topic>Norepinephrine</topic><topic>Phenylethanolamine N-Methyltransferase - metabolism</topic><topic>Pons - enzymology</topic><topic>Rats</topic><topic>Rats, Inbred Strains - metabolism</topic><topic>Receptors</topic><topic>Receptors, Adrenergic - metabolism</topic><topic>Receptors, Adrenergic, alpha - metabolism</topic><topic>Species Specificity</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perry, Bruce D.</creatorcontrib><creatorcontrib>Stolk, Jon M.</creatorcontrib><creatorcontrib>Vantini, Guido</creatorcontrib><creatorcontrib>Guchhait, Ras B.</creatorcontrib><creatorcontrib>David C. 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U'Prichard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strain Differences in Rat Brain Epinephrine Synthesis: Regulation of α-adrenergic Receptor Number by Epinephrine</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1983-09-23</date><risdate>1983</risdate><volume>221</volume><issue>4617</issue><spage>1297</spage><epage>1299</epage><pages>1297-1299</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Inbred rat strains Fischer 344 (F344) and Buffalo (BUF) differ in several physiological and behavioral measures. It was found that the activity of adrenomedullary and regional brain phenylethanolamine N-methyltransferase is at least four times higher in F344 rats than in BUF rats: these strain-dependent differences corresponded directly with the epinephrine content of the medulla-pons and hypothalamus. Conversely, α-adrenergic receptor density in brain regions containing phenylethanolamine N-methyltransferase is two to three times lower in F344 rats than in BUF rats, α-receptors in frontal cortex (a brain region laking phenylethanolamine N-methyltransferase activity and epinephrine) are similar in both strains. These findings suggest that strain-dependent differences in α-receptors are regulated by inherited differences in presynaptic adrenergic neuronal function in different brain regions.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>6310752</pmid><doi>10.1126/science.6310752</doi><tpages>3</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 1983-09, Vol.221 (4617), p.1297-1299 |
| issn | 0036-8075 1095-9203 |
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| source | MEDLINE; Science Magazine; Jstor Complete Legacy |
| subjects | Adrenal Medulla - enzymology Adrenergics Animals Biological and medical sciences Brain Brain - metabolism Catecholamines Cell Membrane - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - enzymology Epinephrine - physiology Female Fundamental and applied biological sciences. Psychology Gene expression regulation Hypothalamus - enzymology Inbred strains Inbreeding Medulla Oblongata - enzymology Neurons Norepinephrine Phenylethanolamine N-Methyltransferase - metabolism Pons - enzymology Rats Rats, Inbred Strains - metabolism Receptors Receptors, Adrenergic - metabolism Receptors, Adrenergic, alpha - metabolism Species Specificity Vertebrates: nervous system and sense organs |
| title | Strain Differences in Rat Brain Epinephrine Synthesis: Regulation of α-adrenergic Receptor Number by Epinephrine |
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