BRAIN TISSUE GRAFTS IN THE CENTRAL NERVOUS SYSTEM: REVERSAL OF HYPOGONADISM
Transplantation of brain tissue from normal donors into the central nervous system of animals with specific central neurochemical deficiencies has been used to remedy such defects. The present studies demonstrate that the hypogonadism present in the adult male hypogonadal ( hpg ) mouse that is secon...
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| Veröffentlicht in: | Experimental physiology 1983-07, Vol.68 (3), p.475-482 |
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| container_title | Experimental physiology |
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| creator | Gibson, M. J. Krieger, D. T. Perlow, M. J. Davies, T. F. Zimmerman, E. A. Ferin, M. Charlton, H. M. |
| description | Transplantation of brain tissue from normal donors into the central nervous system of animals with specific central neurochemical
deficiencies has been used to remedy such defects. The present studies demonstrate that the hypogonadism present in the adult
male hypogonadal ( hpg ) mouse that is secondary to hypothalamic gonadotropin releasing hormone (GnRH) deficiency can be corrected by grafts into
the anterior third ventricle of fetal preoptic area (p.o.a.) tissue. The p.o.a. is a primary site of localization of GnRH
neurones in rodents. As compared with untreated hpg males, or with hpg males that had received control cortical tissue implants, the hpg animals with p.o.a. grafts showed measurable levels of GnRH within the hypothalamus. Immunocytochemical studies revealed
GnRH within the transplants. Increased pituitary and plasma LH and FSH, and testicular growth with full spermatogenesis, were
also evident in the hpg males that had received p.o.a. implants. |
| doi_str_mv | 10.1113/expphysiol.1983.sp002740 |
| format | Article |
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deficiencies has been used to remedy such defects. The present studies demonstrate that the hypogonadism present in the adult
male hypogonadal ( hpg ) mouse that is secondary to hypothalamic gonadotropin releasing hormone (GnRH) deficiency can be corrected by grafts into
the anterior third ventricle of fetal preoptic area (p.o.a.) tissue. The p.o.a. is a primary site of localization of GnRH
neurones in rodents. As compared with untreated hpg males, or with hpg males that had received control cortical tissue implants, the hpg animals with p.o.a. grafts showed measurable levels of GnRH within the hypothalamus. Immunocytochemical studies revealed
GnRH within the transplants. Increased pituitary and plasma LH and FSH, and testicular growth with full spermatogenesis, were
also evident in the hpg males that had received p.o.a. implants.</description><identifier>ISSN: 0958-0670</identifier><identifier>ISSN: 0144-8757</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.1983.sp002740</identifier><identifier>PMID: 6412277</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Follicle Stimulating Hormone - analysis ; Hypogonadism - surgery ; Luteinizing Hormone - analysis ; Male ; Mice ; Nerve Tissue - transplantation ; Organ Size ; Pituitary Hormone-Releasing Hormones - analysis ; Testis - pathology</subject><ispartof>Experimental physiology, 1983-07, Vol.68 (3), p.475-482</ispartof><rights>1983 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4515-d6f0d555bcf7152dd4e682f4660858abfbae8067c21e37b0feacb4f42bfa677e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.1983.sp002740$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.1983.sp002740$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6412277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibson, M. J.</creatorcontrib><creatorcontrib>Krieger, D. T.</creatorcontrib><creatorcontrib>Perlow, M. J.</creatorcontrib><creatorcontrib>Davies, T. F.</creatorcontrib><creatorcontrib>Zimmerman, E. A.</creatorcontrib><creatorcontrib>Ferin, M.</creatorcontrib><creatorcontrib>Charlton, H. M.</creatorcontrib><title>BRAIN TISSUE GRAFTS IN THE CENTRAL NERVOUS SYSTEM: REVERSAL OF HYPOGONADISM</title><title>Experimental physiology</title><addtitle>Q J Exp Physiol</addtitle><description>Transplantation of brain tissue from normal donors into the central nervous system of animals with specific central neurochemical
deficiencies has been used to remedy such defects. The present studies demonstrate that the hypogonadism present in the adult
male hypogonadal ( hpg ) mouse that is secondary to hypothalamic gonadotropin releasing hormone (GnRH) deficiency can be corrected by grafts into
the anterior third ventricle of fetal preoptic area (p.o.a.) tissue. The p.o.a. is a primary site of localization of GnRH
neurones in rodents. As compared with untreated hpg males, or with hpg males that had received control cortical tissue implants, the hpg animals with p.o.a. grafts showed measurable levels of GnRH within the hypothalamus. Immunocytochemical studies revealed
GnRH within the transplants. Increased pituitary and plasma LH and FSH, and testicular growth with full spermatogenesis, were
also evident in the hpg males that had received p.o.a. implants.</description><subject>Animals</subject><subject>Follicle Stimulating Hormone - analysis</subject><subject>Hypogonadism - surgery</subject><subject>Luteinizing Hormone - analysis</subject><subject>Male</subject><subject>Mice</subject><subject>Nerve Tissue - transplantation</subject><subject>Organ Size</subject><subject>Pituitary Hormone-Releasing Hormones - analysis</subject><subject>Testis - pathology</subject><issn>0958-0670</issn><issn>0144-8757</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAURS0EgjJ8ApJX7FLsxFPZheIOojQoSRGsrAw2DUpJiFtB_55ELbBl9aR3733DAQBi1McYe9f6q66XW1tUZR8PhNe3NUIuJ-gA9DBhA4cQ-nwIemhAhYMYRyfg1No3hLCHBDkGx4xg1-W8B-5vQ386h_E0ihYSjkN_FEewa0wkHMp5HPozOJfhU7CIYPQSxfLhBobySYZRKwQjOHl5DMbB3L-bRg_n4MgkpdUX-3oGFiMZDyfOLBhPh_7MyQjF1MmZQTmlNM0Mx9TNc6KZcA1hDAkqktSkiRbt0ZmLtcdTZHSSpcQQNzUJ41x7Z-BqN7duqo-Ntmu1KmymyzJ519XGqjZMXIJ4axQ7Y9ZU1jbaqLopVkmzVRipjqP646g6juqHYxu93O_YpCud_wb34Fp9uNM_i1Jv_z1XycdJ12DCI5z-fbIsXpefRaPVLmWrrNDrdptQnuqM39Ytj5g</recordid><startdate>19830716</startdate><enddate>19830716</enddate><creator>Gibson, M. J.</creator><creator>Krieger, D. T.</creator><creator>Perlow, M. J.</creator><creator>Davies, T. F.</creator><creator>Zimmerman, E. A.</creator><creator>Ferin, M.</creator><creator>Charlton, H. M.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830716</creationdate><title>BRAIN TISSUE GRAFTS IN THE CENTRAL NERVOUS SYSTEM: REVERSAL OF HYPOGONADISM</title><author>Gibson, M. J. ; Krieger, D. T. ; Perlow, M. J. ; Davies, T. F. ; Zimmerman, E. A. ; Ferin, M. ; Charlton, H. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4515-d6f0d555bcf7152dd4e682f4660858abfbae8067c21e37b0feacb4f42bfa677e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Follicle Stimulating Hormone - analysis</topic><topic>Hypogonadism - surgery</topic><topic>Luteinizing Hormone - analysis</topic><topic>Male</topic><topic>Mice</topic><topic>Nerve Tissue - transplantation</topic><topic>Organ Size</topic><topic>Pituitary Hormone-Releasing Hormones - analysis</topic><topic>Testis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibson, M. J.</creatorcontrib><creatorcontrib>Krieger, D. T.</creatorcontrib><creatorcontrib>Perlow, M. J.</creatorcontrib><creatorcontrib>Davies, T. F.</creatorcontrib><creatorcontrib>Zimmerman, E. A.</creatorcontrib><creatorcontrib>Ferin, M.</creatorcontrib><creatorcontrib>Charlton, H. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibson, M. J.</au><au>Krieger, D. T.</au><au>Perlow, M. J.</au><au>Davies, T. F.</au><au>Zimmerman, E. A.</au><au>Ferin, M.</au><au>Charlton, H. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BRAIN TISSUE GRAFTS IN THE CENTRAL NERVOUS SYSTEM: REVERSAL OF HYPOGONADISM</atitle><jtitle>Experimental physiology</jtitle><addtitle>Q J Exp Physiol</addtitle><date>1983-07-16</date><risdate>1983</risdate><volume>68</volume><issue>3</issue><spage>475</spage><epage>482</epage><pages>475-482</pages><issn>0958-0670</issn><issn>0144-8757</issn><eissn>1469-445X</eissn><abstract>Transplantation of brain tissue from normal donors into the central nervous system of animals with specific central neurochemical
deficiencies has been used to remedy such defects. The present studies demonstrate that the hypogonadism present in the adult
male hypogonadal ( hpg ) mouse that is secondary to hypothalamic gonadotropin releasing hormone (GnRH) deficiency can be corrected by grafts into
the anterior third ventricle of fetal preoptic area (p.o.a.) tissue. The p.o.a. is a primary site of localization of GnRH
neurones in rodents. As compared with untreated hpg males, or with hpg males that had received control cortical tissue implants, the hpg animals with p.o.a. grafts showed measurable levels of GnRH within the hypothalamus. Immunocytochemical studies revealed
GnRH within the transplants. Increased pituitary and plasma LH and FSH, and testicular growth with full spermatogenesis, were
also evident in the hpg males that had received p.o.a. implants.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>6412277</pmid><doi>10.1113/expphysiol.1983.sp002740</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental physiology, 1983-07, Vol.68 (3), p.475-482 |
| issn | 0958-0670 0144-8757 1469-445X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Animals Follicle Stimulating Hormone - analysis Hypogonadism - surgery Luteinizing Hormone - analysis Male Mice Nerve Tissue - transplantation Organ Size Pituitary Hormone-Releasing Hormones - analysis Testis - pathology |
| title | BRAIN TISSUE GRAFTS IN THE CENTRAL NERVOUS SYSTEM: REVERSAL OF HYPOGONADISM |
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