Carbamylated Haemoglobin, Urea Kinetic Modelling and Adequacy of Dialysis in Haemodialysis Patients
Urea kinetic modelling (UKM) has increasingly been used for assessing adequacy of dialysis and protein nutritional status of dialysis patients. Using a precise HPLC method we developed, we measured carbamylated haemoglobin (CarHb) values in 20 stable twice-weekly dialysed patients and attempted to c...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 1991, Vol.6 (1), p.38-43 |
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| container_title | Nephrology, dialysis, transplantation |
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| creator | Kwan, J. T. C. Carr, E. C. Neal, A. D. Burdon, J. Raftery, M. J. Marsh, F. P. Barron, J. L. Bending, M. R. |
| description | Urea kinetic modelling (UKM) has increasingly been used for assessing adequacy of dialysis and protein nutritional status of dialysis patients. Using a precise HPLC method we developed, we measured carbamylated haemoglobin (CarHb) values in 20 stable twice-weekly dialysed patients and attempted to correlate their CarHb values with their UKM-derived indices. Based on these indices, 11 patients were found to have been adequately dialysed with sufficient protein intake, three patients were adequately dialysed but malnourished and six patients were under-dialysed. Estimated dietary protein intake correlated poorly with calculated daily protein catabolic rate in our patients. CarHb values were found to correlate strongly with the time-averaged urea concentrations, suggesting that CarHb might be a time-integrated urea-derived index. Those adequately dialysed patients have a mean (SD) CarHb value of 142 (29) μg CV/gHb against the underdialysed patients, 197 (30) μg CV/gHb (t-test, P=0.002). We suggest that a CarHb value 175 μg CV/gHb is undesirable. |
| doi_str_mv | 10.1093/ndt/6.1.38 |
| format | Article |
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T. C. ; Carr, E. C. ; Neal, A. D. ; Burdon, J. ; Raftery, M. J. ; Marsh, F. P. ; Barron, J. L. ; Bending, M. R.</creator><creatorcontrib>Kwan, J. T. C. ; Carr, E. C. ; Neal, A. D. ; Burdon, J. ; Raftery, M. J. ; Marsh, F. P. ; Barron, J. L. ; Bending, M. R.</creatorcontrib><description>Urea kinetic modelling (UKM) has increasingly been used for assessing adequacy of dialysis and protein nutritional status of dialysis patients. Using a precise HPLC method we developed, we measured carbamylated haemoglobin (CarHb) values in 20 stable twice-weekly dialysed patients and attempted to correlate their CarHb values with their UKM-derived indices. Based on these indices, 11 patients were found to have been adequately dialysed with sufficient protein intake, three patients were adequately dialysed but malnourished and six patients were under-dialysed. Estimated dietary protein intake correlated poorly with calculated daily protein catabolic rate in our patients. CarHb values were found to correlate strongly with the time-averaged urea concentrations, suggesting that CarHb might be a time-integrated urea-derived index. Those adequately dialysed patients have a mean (SD) CarHb value of 142 (29) μg CV/gHb against the underdialysed patients, 197 (30) μg CV/gHb (t-test, P=0.002). We suggest that a CarHb value <175 μg CV/gHb may represent satisfactory uraemic exposure, whereas CarHb value >175 μg CV/gHb is undesirable.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/6.1.38</identifier><identifier>PMID: 2057114</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adequacy of dialysis ; Adult ; Aged ; Carbamylated haemoglobin ; Female ; Haemodialysis ; Hemoglobins - metabolism ; High-performance liquid chromatography ; Humans ; Kinetics ; Male ; Middle Aged ; Models, Biological ; Proteins - metabolism ; Renal Dialysis ; Urea - metabolism ; Urea kinetic modelling ; Uremia - metabolism ; Uremia - therapy</subject><ispartof>Nephrology, dialysis, transplantation, 1991, Vol.6 (1), p.38-43</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c235t-44b25daca1bb8e8306957b49f8fa446a3f81a186c752e8869629802a843baa913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2057114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwan, J. T. C.</creatorcontrib><creatorcontrib>Carr, E. C.</creatorcontrib><creatorcontrib>Neal, A. D.</creatorcontrib><creatorcontrib>Burdon, J.</creatorcontrib><creatorcontrib>Raftery, M. J.</creatorcontrib><creatorcontrib>Marsh, F. P.</creatorcontrib><creatorcontrib>Barron, J. L.</creatorcontrib><creatorcontrib>Bending, M. R.</creatorcontrib><title>Carbamylated Haemoglobin, Urea Kinetic Modelling and Adequacy of Dialysis in Haemodialysis Patients</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Urea kinetic modelling (UKM) has increasingly been used for assessing adequacy of dialysis and protein nutritional status of dialysis patients. Using a precise HPLC method we developed, we measured carbamylated haemoglobin (CarHb) values in 20 stable twice-weekly dialysed patients and attempted to correlate their CarHb values with their UKM-derived indices. Based on these indices, 11 patients were found to have been adequately dialysed with sufficient protein intake, three patients were adequately dialysed but malnourished and six patients were under-dialysed. Estimated dietary protein intake correlated poorly with calculated daily protein catabolic rate in our patients. CarHb values were found to correlate strongly with the time-averaged urea concentrations, suggesting that CarHb might be a time-integrated urea-derived index. Those adequately dialysed patients have a mean (SD) CarHb value of 142 (29) μg CV/gHb against the underdialysed patients, 197 (30) μg CV/gHb (t-test, P=0.002). We suggest that a CarHb value <175 μg CV/gHb may represent satisfactory uraemic exposure, whereas CarHb value >175 μg CV/gHb is undesirable.</description><subject>Adequacy of dialysis</subject><subject>Adult</subject><subject>Aged</subject><subject>Carbamylated haemoglobin</subject><subject>Female</subject><subject>Haemodialysis</subject><subject>Hemoglobins - metabolism</subject><subject>High-performance liquid chromatography</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Proteins - metabolism</subject><subject>Renal Dialysis</subject><subject>Urea - metabolism</subject><subject>Urea kinetic modelling</subject><subject>Uremia - metabolism</subject><subject>Uremia - therapy</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AURgdRaq1u3AuzciGmnVfmsZT4qFixCwviZrhJJmU0jzaTgv33Rlq7unDPuR-XD6FLSsaUGD6p824ix3TM9REaUiFJxLiOj9GwhzQiMTGn6CyEL0KIYUoN0ICRWFEqhihLoE2h2pbQuRxPwVXNsmxSX9_iResAv_jadT7Dr03uytLXSwx1ju9yt95AtsVNge89lNvgA_b17j7_X8yh867uwjk6KaAM7mI_R2jx-PCeTKPZ29NzcjeLMsbjLhIiZXEOGdA01U5zIk2sUmEKXYAQEnihKVAtMxUzp7U0khlNGGjBUwBD-Qhd73JXbbPeuNDZyoesfxtq12yC1URyRRnrxZudmLVNCK0r7Kr1FbRbS4n9a9T2jVppqeW6l6_2qZu0cvlB3VfY82jHfejczwFD-22l4iq2049PK9TcCJ1IS_gv5JGAMg</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Kwan, J. T. C.</creator><creator>Carr, E. C.</creator><creator>Neal, A. D.</creator><creator>Burdon, J.</creator><creator>Raftery, M. J.</creator><creator>Marsh, F. P.</creator><creator>Barron, J. L.</creator><creator>Bending, M. R.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Carbamylated Haemoglobin, Urea Kinetic Modelling and Adequacy of Dialysis in Haemodialysis Patients</title><author>Kwan, J. T. C. ; Carr, E. C. ; Neal, A. D. ; Burdon, J. ; Raftery, M. J. ; Marsh, F. P. ; Barron, J. L. ; Bending, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-44b25daca1bb8e8306957b49f8fa446a3f81a186c752e8869629802a843baa913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adequacy of dialysis</topic><topic>Adult</topic><topic>Aged</topic><topic>Carbamylated haemoglobin</topic><topic>Female</topic><topic>Haemodialysis</topic><topic>Hemoglobins - metabolism</topic><topic>High-performance liquid chromatography</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Proteins - metabolism</topic><topic>Renal Dialysis</topic><topic>Urea - metabolism</topic><topic>Urea kinetic modelling</topic><topic>Uremia - metabolism</topic><topic>Uremia - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwan, J. T. C.</creatorcontrib><creatorcontrib>Carr, E. C.</creatorcontrib><creatorcontrib>Neal, A. D.</creatorcontrib><creatorcontrib>Burdon, J.</creatorcontrib><creatorcontrib>Raftery, M. J.</creatorcontrib><creatorcontrib>Marsh, F. P.</creatorcontrib><creatorcontrib>Barron, J. L.</creatorcontrib><creatorcontrib>Bending, M. R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwan, J. T. C.</au><au>Carr, E. C.</au><au>Neal, A. D.</au><au>Burdon, J.</au><au>Raftery, M. J.</au><au>Marsh, F. P.</au><au>Barron, J. L.</au><au>Bending, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbamylated Haemoglobin, Urea Kinetic Modelling and Adequacy of Dialysis in Haemodialysis Patients</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>1991</date><risdate>1991</risdate><volume>6</volume><issue>1</issue><spage>38</spage><epage>43</epage><pages>38-43</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Urea kinetic modelling (UKM) has increasingly been used for assessing adequacy of dialysis and protein nutritional status of dialysis patients. Using a precise HPLC method we developed, we measured carbamylated haemoglobin (CarHb) values in 20 stable twice-weekly dialysed patients and attempted to correlate their CarHb values with their UKM-derived indices. Based on these indices, 11 patients were found to have been adequately dialysed with sufficient protein intake, three patients were adequately dialysed but malnourished and six patients were under-dialysed. Estimated dietary protein intake correlated poorly with calculated daily protein catabolic rate in our patients. CarHb values were found to correlate strongly with the time-averaged urea concentrations, suggesting that CarHb might be a time-integrated urea-derived index. Those adequately dialysed patients have a mean (SD) CarHb value of 142 (29) μg CV/gHb against the underdialysed patients, 197 (30) μg CV/gHb (t-test, P=0.002). We suggest that a CarHb value <175 μg CV/gHb may represent satisfactory uraemic exposure, whereas CarHb value >175 μg CV/gHb is undesirable.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>2057114</pmid><doi>10.1093/ndt/6.1.38</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0931-0509 |
| ispartof | Nephrology, dialysis, transplantation, 1991, Vol.6 (1), p.38-43 |
| issn | 0931-0509 1460-2385 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adequacy of dialysis Adult Aged Carbamylated haemoglobin Female Haemodialysis Hemoglobins - metabolism High-performance liquid chromatography Humans Kinetics Male Middle Aged Models, Biological Proteins - metabolism Renal Dialysis Urea - metabolism Urea kinetic modelling Uremia - metabolism Uremia - therapy |
| title | Carbamylated Haemoglobin, Urea Kinetic Modelling and Adequacy of Dialysis in Haemodialysis Patients |
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