Diminution of ethanol-induced hyperglycaemia in the rat by administration of beta-lactam antibiotics with a tetrazole thiol group
The acute-onset hyperglycaemia produced by i.p. injection of 2 g of ethanol / kg body weight in adult female SPF Sprague-Dawley rats (200–220 g) was considerably less pronounced when 100 μmol/kg b.w. of one of the following tetrazole thiol-containing beta-lactam antibiotics (BLAs) was given i.p. 3 h...
Gespeichert in:
| Veröffentlicht in: | Pharmacological research communications 1983-06, Vol.15 (6), p.631-640 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 640 |
|---|---|
| container_issue | 6 |
| container_start_page | 631 |
| container_title | Pharmacological research communications |
| container_volume | 15 |
| creator | Römer, K.G. Alanis, O. Torres Garcia de Torres, G. Freundt, K.J. |
| description | The acute-onset hyperglycaemia produced by i.p. injection of 2 g of ethanol / kg body weight in adult female SPF Sprague-Dawley rats (200–220 g) was considerably less pronounced when 100 μmol/kg b.w. of one of the following tetrazole thiol-containing beta-lactam antibiotics (BLAs) was given i.p. 3 hours in advance: cephamandole (CMD), moxalactam (MOX), cephoperazone (CPZ) or cephothiam (CTM). An equimolar dose of cephazolin (CEZ), a thiadiazole thiol-containing cephalosporin, did not affect the ethanol-induced hyperglycaemia. Administration of an equimolar oral dose of disulfiram, which has an NCS structure similar to that of the tetrazole thiol-containing BLAs, produced an additional increase of the ethanol-induced hyperglycaemia. The diminution of the ethanol-induced hyperglycaemia by BLAs with a tetrazole thiol group appears to be linked to their NCS structure. It is conceivable that this effect which might be important for human therapy, is causally related to an inhibition of the glycolytic or gluconeogenetic enzyme system. |
| doi_str_mv | 10.1016/S0031-6989(83)80034-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80636482</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0031698983800344</els_id><sourcerecordid>80636482</sourcerecordid><originalsourceid>FETCH-LOGICAL-c223t-1bccdcbdfa99f3b0fe876fb909060e1302e7c4606a1cc498065ce1b4492e2b623</originalsourceid><addsrcrecordid>eNqFkD1vFDEQhi1EFC6BnxDJFYJiwV_x2RVCAUKkSCmA2rK9s7lBu-vD9oIuHf8cX-6Ulsp6Ne8zIz-EXHD2jjOu339jTPJOW2PfGPnWtKQ69YysuFnbTlipn5PVU-UFOSvlZ4tCc3ZKTrUxVgm9In8_4YTzUjHNNA0U6sbPaexw7pcIPd3stpDvx130MKGnONO6AZp9pWFHfd9QLLXFIx6g-m70sfqJ-rliwFQxFvoH64Z6WqF1H9IIbQumkd7ntGxfkpPBjwVeHd9z8uPL5-9XX7vbu-ubq4-3XRRC1o6HGPsY-sFbO8jABjBrPQTLLNMMuGQC1lFppj2PUVnD9GUEHpSyAkTQQp6T14e925x-LVCqm7BEGEc_Q1qKa4TUyuyLl4dizKmUDIPbZpx83jnO3F69e1Tv9l6dke5RvVONuzgeWMIE_RN1dN3mHw5zaL_8jZBdiQhz04wZYnV9wv9c-AcIvpaI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80636482</pqid></control><display><type>article</type><title>Diminution of ethanol-induced hyperglycaemia in the rat by administration of beta-lactam antibiotics with a tetrazole thiol group</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Römer, K.G. ; Alanis, O. Torres ; Garcia de Torres, G. ; Freundt, K.J.</creator><creatorcontrib>Römer, K.G. ; Alanis, O. Torres ; Garcia de Torres, G. ; Freundt, K.J.</creatorcontrib><description>The acute-onset hyperglycaemia produced by i.p. injection of 2 g of ethanol / kg body weight in adult female SPF Sprague-Dawley rats (200–220 g) was considerably less pronounced when 100 μmol/kg b.w. of one of the following tetrazole thiol-containing beta-lactam antibiotics (BLAs) was given i.p. 3 hours in advance: cephamandole (CMD), moxalactam (MOX), cephoperazone (CPZ) or cephothiam (CTM). An equimolar dose of cephazolin (CEZ), a thiadiazole thiol-containing cephalosporin, did not affect the ethanol-induced hyperglycaemia. Administration of an equimolar oral dose of disulfiram, which has an NCS structure similar to that of the tetrazole thiol-containing BLAs, produced an additional increase of the ethanol-induced hyperglycaemia. The diminution of the ethanol-induced hyperglycaemia by BLAs with a tetrazole thiol group appears to be linked to their NCS structure. It is conceivable that this effect which might be important for human therapy, is causally related to an inhibition of the glycolytic or gluconeogenetic enzyme system.</description><identifier>ISSN: 0031-6989</identifier><identifier>EISSN: 1879-2936</identifier><identifier>DOI: 10.1016/S0031-6989(83)80034-4</identifier><identifier>PMID: 6889426</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; beta-Lactams ; Blood Glucose - metabolism ; Ethanol - antagonists & inhibitors ; Female ; Half-Life ; Rats ; Rats, Inbred Strains ; Sulfhydryl Compounds - pharmacology ; Tetrazoles - pharmacology ; Time Factors</subject><ispartof>Pharmacological research communications, 1983-06, Vol.15 (6), p.631-640</ispartof><rights>1983 The Italian Pharmacological Society</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c223t-1bccdcbdfa99f3b0fe876fb909060e1302e7c4606a1cc498065ce1b4492e2b623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6889426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Römer, K.G.</creatorcontrib><creatorcontrib>Alanis, O. Torres</creatorcontrib><creatorcontrib>Garcia de Torres, G.</creatorcontrib><creatorcontrib>Freundt, K.J.</creatorcontrib><title>Diminution of ethanol-induced hyperglycaemia in the rat by administration of beta-lactam antibiotics with a tetrazole thiol group</title><title>Pharmacological research communications</title><addtitle>Pharmacol Res Commun</addtitle><description>The acute-onset hyperglycaemia produced by i.p. injection of 2 g of ethanol / kg body weight in adult female SPF Sprague-Dawley rats (200–220 g) was considerably less pronounced when 100 μmol/kg b.w. of one of the following tetrazole thiol-containing beta-lactam antibiotics (BLAs) was given i.p. 3 hours in advance: cephamandole (CMD), moxalactam (MOX), cephoperazone (CPZ) or cephothiam (CTM). An equimolar dose of cephazolin (CEZ), a thiadiazole thiol-containing cephalosporin, did not affect the ethanol-induced hyperglycaemia. Administration of an equimolar oral dose of disulfiram, which has an NCS structure similar to that of the tetrazole thiol-containing BLAs, produced an additional increase of the ethanol-induced hyperglycaemia. The diminution of the ethanol-induced hyperglycaemia by BLAs with a tetrazole thiol group appears to be linked to their NCS structure. It is conceivable that this effect which might be important for human therapy, is causally related to an inhibition of the glycolytic or gluconeogenetic enzyme system.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>beta-Lactams</subject><subject>Blood Glucose - metabolism</subject><subject>Ethanol - antagonists & inhibitors</subject><subject>Female</subject><subject>Half-Life</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sulfhydryl Compounds - pharmacology</subject><subject>Tetrazoles - pharmacology</subject><subject>Time Factors</subject><issn>0031-6989</issn><issn>1879-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1vFDEQhi1EFC6BnxDJFYJiwV_x2RVCAUKkSCmA2rK9s7lBu-vD9oIuHf8cX-6Ulsp6Ne8zIz-EXHD2jjOu339jTPJOW2PfGPnWtKQ69YysuFnbTlipn5PVU-UFOSvlZ4tCc3ZKTrUxVgm9In8_4YTzUjHNNA0U6sbPaexw7pcIPd3stpDvx130MKGnONO6AZp9pWFHfd9QLLXFIx6g-m70sfqJ-rliwFQxFvoH64Z6WqF1H9IIbQumkd7ntGxfkpPBjwVeHd9z8uPL5-9XX7vbu-ubq4-3XRRC1o6HGPsY-sFbO8jABjBrPQTLLNMMuGQC1lFppj2PUVnD9GUEHpSyAkTQQp6T14e925x-LVCqm7BEGEc_Q1qKa4TUyuyLl4dizKmUDIPbZpx83jnO3F69e1Tv9l6dke5RvVONuzgeWMIE_RN1dN3mHw5zaL_8jZBdiQhz04wZYnV9wv9c-AcIvpaI</recordid><startdate>198306</startdate><enddate>198306</enddate><creator>Römer, K.G.</creator><creator>Alanis, O. Torres</creator><creator>Garcia de Torres, G.</creator><creator>Freundt, K.J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198306</creationdate><title>Diminution of ethanol-induced hyperglycaemia in the rat by administration of beta-lactam antibiotics with a tetrazole thiol group</title><author>Römer, K.G. ; Alanis, O. Torres ; Garcia de Torres, G. ; Freundt, K.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c223t-1bccdcbdfa99f3b0fe876fb909060e1302e7c4606a1cc498065ce1b4492e2b623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>beta-Lactams</topic><topic>Blood Glucose - metabolism</topic><topic>Ethanol - antagonists & inhibitors</topic><topic>Female</topic><topic>Half-Life</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sulfhydryl Compounds - pharmacology</topic><topic>Tetrazoles - pharmacology</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Römer, K.G.</creatorcontrib><creatorcontrib>Alanis, O. Torres</creatorcontrib><creatorcontrib>Garcia de Torres, G.</creatorcontrib><creatorcontrib>Freundt, K.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Römer, K.G.</au><au>Alanis, O. Torres</au><au>Garcia de Torres, G.</au><au>Freundt, K.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diminution of ethanol-induced hyperglycaemia in the rat by administration of beta-lactam antibiotics with a tetrazole thiol group</atitle><jtitle>Pharmacological research communications</jtitle><addtitle>Pharmacol Res Commun</addtitle><date>1983-06</date><risdate>1983</risdate><volume>15</volume><issue>6</issue><spage>631</spage><epage>640</epage><pages>631-640</pages><issn>0031-6989</issn><eissn>1879-2936</eissn><abstract>The acute-onset hyperglycaemia produced by i.p. injection of 2 g of ethanol / kg body weight in adult female SPF Sprague-Dawley rats (200–220 g) was considerably less pronounced when 100 μmol/kg b.w. of one of the following tetrazole thiol-containing beta-lactam antibiotics (BLAs) was given i.p. 3 hours in advance: cephamandole (CMD), moxalactam (MOX), cephoperazone (CPZ) or cephothiam (CTM). An equimolar dose of cephazolin (CEZ), a thiadiazole thiol-containing cephalosporin, did not affect the ethanol-induced hyperglycaemia. Administration of an equimolar oral dose of disulfiram, which has an NCS structure similar to that of the tetrazole thiol-containing BLAs, produced an additional increase of the ethanol-induced hyperglycaemia. The diminution of the ethanol-induced hyperglycaemia by BLAs with a tetrazole thiol group appears to be linked to their NCS structure. It is conceivable that this effect which might be important for human therapy, is causally related to an inhibition of the glycolytic or gluconeogenetic enzyme system.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>6889426</pmid><doi>10.1016/S0031-6989(83)80034-4</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6989 |
| ispartof | Pharmacological research communications, 1983-06, Vol.15 (6), p.631-640 |
| issn | 0031-6989 1879-2936 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80636482 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anti-Bacterial Agents - pharmacology beta-Lactams Blood Glucose - metabolism Ethanol - antagonists & inhibitors Female Half-Life Rats Rats, Inbred Strains Sulfhydryl Compounds - pharmacology Tetrazoles - pharmacology Time Factors |
| title | Diminution of ethanol-induced hyperglycaemia in the rat by administration of beta-lactam antibiotics with a tetrazole thiol group |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T16%3A20%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diminution%20of%20ethanol-induced%20hyperglycaemia%20in%20the%20rat%20by%20administration%20of%20beta-lactam%20antibiotics%20with%20a%20tetrazole%20thiol%20group&rft.jtitle=Pharmacological%20research%20communications&rft.au=R%C3%B6mer,%20K.G.&rft.date=1983-06&rft.volume=15&rft.issue=6&rft.spage=631&rft.epage=640&rft.pages=631-640&rft.issn=0031-6989&rft.eissn=1879-2936&rft_id=info:doi/10.1016/S0031-6989(83)80034-4&rft_dat=%3Cproquest_cross%3E80636482%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80636482&rft_id=info:pmid/6889426&rft_els_id=S0031698983800344&rfr_iscdi=true |