Nonlinear dobutamine pharmacokinetics in a pediatric population
OBJECTIVETo evaluate a linear kinetic model for dobutamine clearance. DESIGNA prospective evaluation of pediatric patients receiving continuous infusions of dobutamine at varying doses. SETTINGA pediatric critical care unit. PATIENTSTwelve patients age 2 days to 9 yrs and weighing 2.7 to 33 kg who r...
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| Veröffentlicht in: | Critical care medicine 1991-07, Vol.19 (7), p.871-873 |
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| creator | BANNER, WILLIAM VERNON, DONALD D MINTON, STEVEN D DEAN, J MICHAEL |
| description | OBJECTIVETo evaluate a linear kinetic model for dobutamine clearance.
DESIGNA prospective evaluation of pediatric patients receiving continuous infusions of dobutamine at varying doses.
SETTINGA pediatric critical care unit.
PATIENTSTwelve patients age 2 days to 9 yrs and weighing 2.7 to 33 kg who required vasopressor therapy. Infusion rates for dobutamine ranged from 2 to 15 μg/kg-min.
MEASUREMENTS AND MAIN RESULTSSerum concentrations varied from 6.4 to 347 ng/mL (21 to 1151 nmol/L). Concentration was found to increase with dose. However, the relationship of clearance to steady-state concentration had a negative slope. Values for clearance varied from 32 to 625 mL/kg-min. Multiple analysis of variance on age, weight, and co-infused do-pamine showed that these factors did not influence the relationship of clearance to steady-state concentration. Analysis to show an underlying model failed to differentiate Michaelis-Menten from nonlinear binding or mixed models on the basis of these data.
CONCLUSIONSDobutamine pharmacokinetics do not appear to follow a simple linear model. Based on the current data, neither age nor the added infusion of dopamine affects the clearance of dobutamine. (Crit Care Med 1991; 19:871) |
| doi_str_mv | 10.1097/00003246-199107000-00008 |
| format | Article |
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DESIGNA prospective evaluation of pediatric patients receiving continuous infusions of dobutamine at varying doses.
SETTINGA pediatric critical care unit.
PATIENTSTwelve patients age 2 days to 9 yrs and weighing 2.7 to 33 kg who required vasopressor therapy. Infusion rates for dobutamine ranged from 2 to 15 μg/kg-min.
MEASUREMENTS AND MAIN RESULTSSerum concentrations varied from 6.4 to 347 ng/mL (21 to 1151 nmol/L). Concentration was found to increase with dose. However, the relationship of clearance to steady-state concentration had a negative slope. Values for clearance varied from 32 to 625 mL/kg-min. Multiple analysis of variance on age, weight, and co-infused do-pamine showed that these factors did not influence the relationship of clearance to steady-state concentration. Analysis to show an underlying model failed to differentiate Michaelis-Menten from nonlinear binding or mixed models on the basis of these data.
CONCLUSIONSDobutamine pharmacokinetics do not appear to follow a simple linear model. Based on the current data, neither age nor the added infusion of dopamine affects the clearance of dobutamine. (Crit Care Med 1991; 19:871)</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-199107000-00008</identifier><identifier>PMID: 2055074</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Age Factors ; Biological and medical sciences ; Body Weight ; Cardiotonic agents ; Cardiovascular system ; Child ; Child, Preschool ; Dobutamine - administration & dosage ; Dobutamine - metabolism ; Dobutamine - pharmacokinetics ; Dopamine - administration & dosage ; Dopamine - metabolism ; Dopamine - pharmacokinetics ; Drug Therapy, Combination ; Evaluation Studies as Topic ; Humans ; Infant ; Infant, Newborn ; Infusions, Intravenous ; Linear Models ; Medical sciences ; Metabolic Clearance Rate ; Models, Chemical ; Pharmacology. Drug treatments ; Prospective Studies ; Protein Binding ; Reproducibility of Results</subject><ispartof>Critical care medicine, 1991-07, Vol.19 (7), p.871-873</ispartof><rights>Williams & Wilkins 1991. All Rights Reserved.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3848-8bef3912c8996e503fc0a60c8fdc32599641bd691fa72fc31f221e27a3f877683</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4969921$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2055074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BANNER, WILLIAM</creatorcontrib><creatorcontrib>VERNON, DONALD D</creatorcontrib><creatorcontrib>MINTON, STEVEN D</creatorcontrib><creatorcontrib>DEAN, J MICHAEL</creatorcontrib><title>Nonlinear dobutamine pharmacokinetics in a pediatric population</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVETo evaluate a linear kinetic model for dobutamine clearance.
DESIGNA prospective evaluation of pediatric patients receiving continuous infusions of dobutamine at varying doses.
SETTINGA pediatric critical care unit.
PATIENTSTwelve patients age 2 days to 9 yrs and weighing 2.7 to 33 kg who required vasopressor therapy. Infusion rates for dobutamine ranged from 2 to 15 μg/kg-min.
MEASUREMENTS AND MAIN RESULTSSerum concentrations varied from 6.4 to 347 ng/mL (21 to 1151 nmol/L). Concentration was found to increase with dose. However, the relationship of clearance to steady-state concentration had a negative slope. Values for clearance varied from 32 to 625 mL/kg-min. Multiple analysis of variance on age, weight, and co-infused do-pamine showed that these factors did not influence the relationship of clearance to steady-state concentration. Analysis to show an underlying model failed to differentiate Michaelis-Menten from nonlinear binding or mixed models on the basis of these data.
CONCLUSIONSDobutamine pharmacokinetics do not appear to follow a simple linear model. Based on the current data, neither age nor the added infusion of dopamine affects the clearance of dobutamine. (Crit Care Med 1991; 19:871)</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Cardiotonic agents</subject><subject>Cardiovascular system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dobutamine - administration & dosage</subject><subject>Dobutamine - metabolism</subject><subject>Dobutamine - pharmacokinetics</subject><subject>Dopamine - administration & dosage</subject><subject>Dopamine - metabolism</subject><subject>Dopamine - pharmacokinetics</subject><subject>Drug Therapy, Combination</subject><subject>Evaluation Studies as Topic</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infusions, Intravenous</subject><subject>Linear Models</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Models, Chemical</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Protein Binding</subject><subject>Reproducibility of Results</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLxDAUhYMo4_j4CUIX4q6aR9skKxHxBaIbXYc7acLESZuatIj_3owzzs5sLufcL_fCuQgVBF8SLPkVzo_RqimJlATzrMq1JfbQnNQsCyrZPppjLHHJKskO0VFKHxiTquZshmYU1zXm1Rxdv4Teu95ALNqwmEbosiiGJcQOdFhlMTqdCtcXUAymdTBGp4shDJOH0YX-BB1Y8Mmcbusxer-_e7t9LJ9fH55ub55LzUQlSrEwlklCtZCyMTVmVmNosBa21YzW2azIom0kscCp1YxYSomhHJgVnDeCHaOLzdwhhs_JpFF1LmnjPfQmTEkJ3DAmeZNBsQF1DClFY9UQXQfxWxGs1tmpv-zULrtfa73jbLtjWnSm3X3chpX759s-JA3eRui1Szusko2UlGSs2mBfwY8mppWfvkxUSwN-XKr_Lsd-ADKWhWY</recordid><startdate>199107</startdate><enddate>199107</enddate><creator>BANNER, WILLIAM</creator><creator>VERNON, DONALD D</creator><creator>MINTON, STEVEN D</creator><creator>DEAN, J MICHAEL</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199107</creationdate><title>Nonlinear dobutamine pharmacokinetics in a pediatric population</title><author>BANNER, WILLIAM ; VERNON, DONALD D ; MINTON, STEVEN D ; DEAN, J MICHAEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3848-8bef3912c8996e503fc0a60c8fdc32599641bd691fa72fc31f221e27a3f877683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Cardiotonic agents</topic><topic>Cardiovascular system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dobutamine - administration & dosage</topic><topic>Dobutamine - metabolism</topic><topic>Dobutamine - pharmacokinetics</topic><topic>Dopamine - administration & dosage</topic><topic>Dopamine - metabolism</topic><topic>Dopamine - pharmacokinetics</topic><topic>Drug Therapy, Combination</topic><topic>Evaluation Studies as Topic</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infusions, Intravenous</topic><topic>Linear Models</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Models, Chemical</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Protein Binding</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BANNER, WILLIAM</creatorcontrib><creatorcontrib>VERNON, DONALD D</creatorcontrib><creatorcontrib>MINTON, STEVEN D</creatorcontrib><creatorcontrib>DEAN, J MICHAEL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BANNER, WILLIAM</au><au>VERNON, DONALD D</au><au>MINTON, STEVEN D</au><au>DEAN, J MICHAEL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonlinear dobutamine pharmacokinetics in a pediatric population</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1991-07</date><risdate>1991</risdate><volume>19</volume><issue>7</issue><spage>871</spage><epage>873</epage><pages>871-873</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVETo evaluate a linear kinetic model for dobutamine clearance.
DESIGNA prospective evaluation of pediatric patients receiving continuous infusions of dobutamine at varying doses.
SETTINGA pediatric critical care unit.
PATIENTSTwelve patients age 2 days to 9 yrs and weighing 2.7 to 33 kg who required vasopressor therapy. Infusion rates for dobutamine ranged from 2 to 15 μg/kg-min.
MEASUREMENTS AND MAIN RESULTSSerum concentrations varied from 6.4 to 347 ng/mL (21 to 1151 nmol/L). Concentration was found to increase with dose. However, the relationship of clearance to steady-state concentration had a negative slope. Values for clearance varied from 32 to 625 mL/kg-min. Multiple analysis of variance on age, weight, and co-infused do-pamine showed that these factors did not influence the relationship of clearance to steady-state concentration. Analysis to show an underlying model failed to differentiate Michaelis-Menten from nonlinear binding or mixed models on the basis of these data.
CONCLUSIONSDobutamine pharmacokinetics do not appear to follow a simple linear model. Based on the current data, neither age nor the added infusion of dopamine affects the clearance of dobutamine. (Crit Care Med 1991; 19:871)</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>2055074</pmid><doi>10.1097/00003246-199107000-00008</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Age Factors Biological and medical sciences Body Weight Cardiotonic agents Cardiovascular system Child Child, Preschool Dobutamine - administration & dosage Dobutamine - metabolism Dobutamine - pharmacokinetics Dopamine - administration & dosage Dopamine - metabolism Dopamine - pharmacokinetics Drug Therapy, Combination Evaluation Studies as Topic Humans Infant Infant, Newborn Infusions, Intravenous Linear Models Medical sciences Metabolic Clearance Rate Models, Chemical Pharmacology. Drug treatments Prospective Studies Protein Binding Reproducibility of Results |
| title | Nonlinear dobutamine pharmacokinetics in a pediatric population |
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