Retinoic acid treatment induces type X collagen gene expression in cultured chick chondrocytes

The vitamin A derivative retinoic acid (RA) is widely thought to be involved in cartilage development, but its precise roles and mechanisms of action in this complex process remain unclear. We have tested the hypothesis that RA is involved in chondrocyte maturation during endochondral ossification a...

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Veröffentlicht in:	Experimental cell research 1991-07, Vol.195 (1), p.38-46
Hauptverfasser:	Pacifici, Maurizio, Golden, Eleanor B., Iwamoto, Masahiro, Adams, Sherrill L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Blotting, Northern Cartilage - cytology Cartilage - physiology Cell Differentiation - drug effects Cells, Cultured Chickens Collagen - genetics Collagen - immunology Dose-Response Relationship, Drug Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Other biological molecules Proteoglycans - genetics RNA, Messenger - genetics Tretinoin - pharmacology
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