Effect of chronic guanethidine treatment on vascular norepinephrine content in the neonatal domestic pig
Vinblastine, 6-hydroxydopamine, and antibody to nerve growth factor have been shown to destroy sympathetic neurons in neonatal rats. High doses of guanethidine produce permanent sympathectomies in the adult or newborn rat. Similar studies in the cat, rabbit, and hamster demonstrate that the sympathe...
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| Veröffentlicht in: | Life sciences (1973) 1983-08, Vol.33 (8), p.719-723 |
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| container_title | Life sciences (1973) |
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| creator | Terris, James M. |
| description | Vinblastine, 6-hydroxydopamine, and antibody to nerve growth factor have been shown to destroy sympathetic neurons in neonatal rats. High doses of guanethidine produce permanent sympathectomies in the adult or newborn rat. Similar studies in the cat, rabbit, and hamster demonstrate that the sympathetic nervous systems are not destroyed with guanethidine. To produce permanent sympathectomy in a large animal model, guanethidine was administered to neonatal pigs. As with the cat, rabbit, and hamster, the sympathetic nervous system in the piglets was not destroyed by guanethidine. |
| doi_str_mv | 10.1016/0024-3205(83)90776-2 |
| format | Article |
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High doses of guanethidine produce permanent sympathectomies in the adult or newborn rat. Similar studies in the cat, rabbit, and hamster demonstrate that the sympathetic nervous systems are not destroyed with guanethidine. To produce permanent sympathectomy in a large animal model, guanethidine was administered to neonatal pigs. As with the cat, rabbit, and hamster, the sympathetic nervous system in the piglets was not destroyed by guanethidine.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(83)90776-2</identifier><identifier>PMID: 6888189</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Animals, Newborn - metabolism ; Biological and medical sciences ; Blood Vessels - metabolism ; Catecholaminergic system ; Guanethidine - pharmacology ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. 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High doses of guanethidine produce permanent sympathectomies in the adult or newborn rat. Similar studies in the cat, rabbit, and hamster demonstrate that the sympathetic nervous systems are not destroyed with guanethidine. To produce permanent sympathectomy in a large animal model, guanethidine was administered to neonatal pigs. As with the cat, rabbit, and hamster, the sympathetic nervous system in the piglets was not destroyed by guanethidine.</description><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels - metabolism</subject><subject>Catecholaminergic system</subject><subject>Guanethidine - pharmacology</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Norepinephrine - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Swine - metabolism</subject><subject>Sympathetic Nervous System - drug effects</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAURS0EKpfCH4DkAapgEDiO83AmSKgqD6lSJzC2_DhujBI72Eml_j1O79UdMvJgr7Pts0zIWwafGLDuM0DdVLyG9oPgHwfo-66qn5EDE_1QQcfZc3I4Iy_Jq5z_AEDb9vyCXHRCCCaGAxlvnEOz0uioGVMM3tD7TQVcR299QLomVOuMoRCBPqhstkklGmLCpcTLmHbIxLDuiA90HZEGjEGtaqI2zpjXUrn4-9fkhVNTxjen85L8_nbz6_pHdXv3_ef119vKcN6ule2xBddDq5u-1pw1LbNMq7qpwSnbad0ogMbwRtfCWlSm1c65tsduENpZ5Jfk6ti7pPh3K9fL2WeD01SWiluWoqiB0l_A5giaFHNO6OSS_KzSo2Qgd8Fytyd3e1Jw-SRY1mXs3al_0zPa89DJaMnfn_IiS00uqWB8PmMD77kAKNiXI4bFxYPHJLPxGAxan8p_SBv9_9_xD27AmUg</recordid><startdate>19830822</startdate><enddate>19830822</enddate><creator>Terris, James M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830822</creationdate><title>Effect of chronic guanethidine treatment on vascular norepinephrine content in the neonatal domestic pig</title><author>Terris, James M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-d7e50f705b472b31451d1ba2420fad6bb4a004c34b28ddeac5bfff57e698bfde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels - metabolism</topic><topic>Catecholaminergic system</topic><topic>Guanethidine - pharmacology</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Norepinephrine - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Swine - metabolism</topic><topic>Sympathetic Nervous System - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terris, James M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terris, James M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chronic guanethidine treatment on vascular norepinephrine content in the neonatal domestic pig</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1983-08-22</date><risdate>1983</risdate><volume>33</volume><issue>8</issue><spage>719</spage><epage>723</epage><pages>719-723</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Vinblastine, 6-hydroxydopamine, and antibody to nerve growth factor have been shown to destroy sympathetic neurons in neonatal rats. High doses of guanethidine produce permanent sympathectomies in the adult or newborn rat. Similar studies in the cat, rabbit, and hamster demonstrate that the sympathetic nervous systems are not destroyed with guanethidine. To produce permanent sympathectomy in a large animal model, guanethidine was administered to neonatal pigs. As with the cat, rabbit, and hamster, the sympathetic nervous system in the piglets was not destroyed by guanethidine.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6888189</pmid><doi>10.1016/0024-3205(83)90776-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1983-08, Vol.33 (8), p.719-723 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Animals, Newborn - metabolism Biological and medical sciences Blood Vessels - metabolism Catecholaminergic system Guanethidine - pharmacology Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine - metabolism Pharmacology. Drug treatments Swine - metabolism Sympathetic Nervous System - drug effects |
| title | Effect of chronic guanethidine treatment on vascular norepinephrine content in the neonatal domestic pig |
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