Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling
This study examined the possible involvement of amino acid release from ventral hippocampus in the establishment and maintenance of kindling in rats. Release of amino acids from ventral hippocampus was measured by microdialysis coupled with high-performance liquid chromatography. Samples were obtain...
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| Veröffentlicht in: | Brain research 1991-02, Vol.540 (1), p.315-318 |
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| creator | Zhang, W.Q. Hudson, P.M. Sobotka, T.J. Hong, J.S. Tilson, H.A. |
| description | This study examined the possible involvement of amino acid release from ventral hippocampus in the establishment and maintenance of kindling in rats. Release of amino acids from ventral hippocampus was measured by microdialysis coupled with high-performance liquid chromatography. Samples were obtained by microdialysis perfusion of freely moving animals receiving deep prepiriform cortex (DPC) electrical stimulation. Samples of perfusate were collected before, during and after kindling was established. DPC kindling stimulation significantly increased concentrations of glutamate (Glu) and glycine (Gly) in perfusate from ventral hippocampus during kindling. Increased basal release of Glu was evident up to 30 days after the last electrical stimulation. We conclude that release of Glu and Gly in the ventral hippocampus may play an important role during establishment, but not in maintenance of kindling. |
| doi_str_mv | 10.1016/0006-8993(91)90527-3 |
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Release of amino acids from ventral hippocampus was measured by microdialysis coupled with high-performance liquid chromatography. Samples were obtained by microdialysis perfusion of freely moving animals receiving deep prepiriform cortex (DPC) electrical stimulation. Samples of perfusate were collected before, during and after kindling was established. DPC kindling stimulation significantly increased concentrations of glutamate (Glu) and glycine (Gly) in perfusate from ventral hippocampus during kindling. Increased basal release of Glu was evident up to 30 days after the last electrical stimulation. We conclude that release of Glu and Gly in the ventral hippocampus may play an important role during establishment, but not in maintenance of kindling.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(91)90527-3</identifier><identifier>PMID: 1675918</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Amino acid ; Amino Acids - isolation & purification ; Amino Acids - metabolism ; Animals ; Biological and medical sciences ; Brain dialysis ; Chromatography, High Pressure Liquid ; Dialysis ; Electric Stimulation ; Glutamates - metabolism ; Glutamic Acid ; Glycine - metabolism ; Hippocampus - physiology ; Hippocampus - physiopathology ; Kindling ; Kindling, Neurologic ; Male ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Neurotransmitter Agents - isolation & purification ; Neurotransmitter Agents - metabolism ; Perfusion ; Rats ; Rats, Inbred F344 ; Seizures - physiopathology ; Ventral hippocampus</subject><ispartof>Brain research, 1991-02, Vol.540 (1), p.315-318</ispartof><rights>1991 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-bba79b13d67b76ecd3b3d7e1261964359d6c12868f1b002820178bb8d8ff773b3</citedby><cites>FETCH-LOGICAL-c418t-bba79b13d67b76ecd3b3d7e1261964359d6c12868f1b002820178bb8d8ff773b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(91)90527-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19631761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1675918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, W.Q.</creatorcontrib><creatorcontrib>Hudson, P.M.</creatorcontrib><creatorcontrib>Sobotka, T.J.</creatorcontrib><creatorcontrib>Hong, J.S.</creatorcontrib><creatorcontrib>Tilson, H.A.</creatorcontrib><title>Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>This study examined the possible involvement of amino acid release from ventral hippocampus in the establishment and maintenance of kindling in rats. Release of amino acids from ventral hippocampus was measured by microdialysis coupled with high-performance liquid chromatography. Samples were obtained by microdialysis perfusion of freely moving animals receiving deep prepiriform cortex (DPC) electrical stimulation. Samples of perfusate were collected before, during and after kindling was established. DPC kindling stimulation significantly increased concentrations of glutamate (Glu) and glycine (Gly) in perfusate from ventral hippocampus during kindling. Increased basal release of Glu was evident up to 30 days after the last electrical stimulation. We conclude that release of Glu and Gly in the ventral hippocampus may play an important role during establishment, but not in maintenance of kindling.</description><subject>Amino acid</subject><subject>Amino Acids - isolation & purification</subject><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain dialysis</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dialysis</subject><subject>Electric Stimulation</subject><subject>Glutamates - metabolism</subject><subject>Glutamic Acid</subject><subject>Glycine - metabolism</subject><subject>Hippocampus - physiology</subject><subject>Hippocampus - physiopathology</subject><subject>Kindling</subject><subject>Kindling, Neurologic</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Neurotransmitter Agents - isolation & purification</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Perfusion</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Seizures - physiopathology</subject><subject>Ventral hippocampus</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PFTEYhRsjwSv4DyTpRqKLkb7Te_uxISEElYTEDaybfo1UZtqxnbnR-OftcG9kB6um7_uck_YchN4D-QwE2BkhhDVCSvpRwidJNi1v6Cu0AsHbhrVr8hqt_iNv0NtSftYrpZIcokNgfCNBrNDfq99T1tb3_dzrjG2K1sc6mUKKBacO6yHEhLUNDtdxLEOYJp8LDhFvH8ke34dxTFYP41ywm3OIP7CODuuugni699j5re_TOFR-sXwI0fWVOkYHne6Lf7c_j9Ddl6vby2_Nzfev15cXN41dg5gaYzSXBqhj3HDmraOGOu6hZSDZmm6kYxZawUQHhpBWtAS4MEY40XWcV_gIne58x5x-zb5Maghl-bKOPs1FCcKqnIkXQdiImjPQCq53oM2plOw7NeYw6PxHAVFLOWpJXi3JKwnqsRy1yE72_rMZvHsS7dqo-w_7vS5W913N24byhElGgTOo3PmO8zW1bfBZFRt8bc6F7O2kXArPP-Qf0ietOg</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>Zhang, W.Q.</creator><creator>Hudson, P.M.</creator><creator>Sobotka, T.J.</creator><creator>Hong, J.S.</creator><creator>Tilson, H.A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910201</creationdate><title>Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling</title><author>Zhang, W.Q. ; Hudson, P.M. ; Sobotka, T.J. ; Hong, J.S. ; Tilson, H.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-bba79b13d67b76ecd3b3d7e1261964359d6c12868f1b002820178bb8d8ff773b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amino acid</topic><topic>Amino Acids - isolation & purification</topic><topic>Amino Acids - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain dialysis</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dialysis</topic><topic>Electric Stimulation</topic><topic>Glutamates - metabolism</topic><topic>Glutamic Acid</topic><topic>Glycine - metabolism</topic><topic>Hippocampus - physiology</topic><topic>Hippocampus - physiopathology</topic><topic>Kindling</topic><topic>Kindling, Neurologic</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Neurotransmitter Agents - isolation & purification</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Perfusion</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Seizures - physiopathology</topic><topic>Ventral hippocampus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, W.Q.</creatorcontrib><creatorcontrib>Hudson, P.M.</creatorcontrib><creatorcontrib>Sobotka, T.J.</creatorcontrib><creatorcontrib>Hong, J.S.</creatorcontrib><creatorcontrib>Tilson, H.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, W.Q.</au><au>Hudson, P.M.</au><au>Sobotka, T.J.</au><au>Hong, J.S.</au><au>Tilson, H.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>540</volume><issue>1</issue><spage>315</spage><epage>318</epage><pages>315-318</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>This study examined the possible involvement of amino acid release from ventral hippocampus in the establishment and maintenance of kindling in rats. Release of amino acids from ventral hippocampus was measured by microdialysis coupled with high-performance liquid chromatography. Samples were obtained by microdialysis perfusion of freely moving animals receiving deep prepiriform cortex (DPC) electrical stimulation. Samples of perfusate were collected before, during and after kindling was established. DPC kindling stimulation significantly increased concentrations of glutamate (Glu) and glycine (Gly) in perfusate from ventral hippocampus during kindling. Increased basal release of Glu was evident up to 30 days after the last electrical stimulation. We conclude that release of Glu and Gly in the ventral hippocampus may play an important role during establishment, but not in maintenance of kindling.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1675918</pmid><doi>10.1016/0006-8993(91)90527-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Brain research, 1991-02, Vol.540 (1), p.315-318 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino acid Amino Acids - isolation & purification Amino Acids - metabolism Animals Biological and medical sciences Brain dialysis Chromatography, High Pressure Liquid Dialysis Electric Stimulation Glutamates - metabolism Glutamic Acid Glycine - metabolism Hippocampus - physiology Hippocampus - physiopathology Kindling Kindling, Neurologic Male Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Neurotransmitter Agents - isolation & purification Neurotransmitter Agents - metabolism Perfusion Rats Rats, Inbred F344 Seizures - physiopathology Ventral hippocampus |
| title | Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling |
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