Ocular herpes simplex virus infection is diminished by depletion of B lymphocytes

Rabbit anti-mouse mu-chain serum was used to deplete specifically IgM-bearing B cells and B cell function in BALB/c mice. B cell-depleted and normal littermates were infected via the cornea with herpes simplex virus type 1 (HSV-1) at 4 to 5 wk of age. B cell-depleted mice had a reduced number of lym...

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Veröffentlicht in:	The Journal of immunology (1950) 1983-09, Vol.131 (3), p.1554-1557
Hauptverfasser:	Jordan, C, Baron, S, Dianzani, F, Barber, J, Stanton, GJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Anti-Idiotypic - administration & dosage B-Lymphocytes - immunology Biological and medical sciences Corneal Diseases - etiology Corneal Diseases - immunology Corneal Diseases - therapy Experimental viral diseases and models Herpes Simplex - complications Herpes Simplex - immunology Herpes Simplex - therapy herpes simplex virus 1 Immunoglobulin mu-Chains - immunology Immunosuppression - methods Infectious diseases Lymphocyte Depletion Medical sciences Mice Mice, Inbred BALB C Rabbits Tears - microbiology Viral diseases
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