Identification by direct photoaffinity labeling of an altered phosphodiesterase in a mutant S49 lymphoma cell

Extracts of a mutant S49 lymphoma cell line, termed K30a, hydrolyze cAMP and cGMP at rates much faster than do wild type S49 extracts. This elevated phosphodiesterase activity, called K-PDE, elutes as a single peak of activity on DEAE-cellulose columns (Brothers, V. M., Walker, N., and Bourne, H. R....

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Veröffentlicht in:	The Journal of biological chemistry 1983-08, Vol.258 (16), p.9717-9723
Hauptverfasser:	Groppi, V E, Steinberg, F, Kaslow, H R, Walker, N, Bourne, H R
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - metabolism 3',5'-Cyclic-GMP Phosphodiesterases - metabolism Affinity Labels Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Line Cyclic AMP - metabolism Cyclic GMP - metabolism Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Lymphoma - enzymology Lymphoma - genetics Mutation Neoplasms, Experimental - enzymology Photochemistry
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