A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis
THE genome of the hepatitis C virus (HCV), the etiologic agent of post-transfusion non-A, non-B hepatitis, was recently identified, and the products of viral genes were expressed in prokaryotic and eukaryotic systems. 1 Infection with HCV is routinely diagnosed by identifying in serum specific antib...
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| Veröffentlicht in: | The New England journal of medicine 1991-07, Vol.325 (2), p.98-104 |
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| container_title | The New England journal of medicine |
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| creator | Farci, Patrizia Alter, Harvey J Wong, Doris Miller, Roger H Shih, James W Jett, Betsy Purcell, Robert H |
| description | THE genome of the hepatitis C virus (HCV), the etiologic agent of post-transfusion non-A, non-B hepatitis, was recently identified, and the products of viral genes were expressed in prokaryotic and eukaryotic systems.
1
Infection with HCV is routinely diagnosed by identifying in serum specific antibodies to these expressed proteins.
2
Several studies have shown a clear association between the presence of antibodies to HCV (anti-HCV) and chronic non-A, non-B hepatitis.
3
4
5
6
7
However, antibody testing cannot determine whether a patient with anti-HCV has recovered from the infection or is still carrying the virus and is potentially infectious. In addition, anti-HCV often appears late after . . . |
| doi_str_mv | 10.1056/NEJM199107113250205 |
| format | Article |
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1
Infection with HCV is routinely diagnosed by identifying in serum specific antibodies to these expressed proteins.
2
Several studies have shown a clear association between the presence of antibodies to HCV (anti-HCV) and chronic non-A, non-B hepatitis.
3
4
5
6
7
However, antibody testing cannot determine whether a patient with anti-HCV has recovered from the infection or is still carrying the virus and is potentially infectious. In addition, anti-HCV often appears late after . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199107113250205</identifier><identifier>PMID: 1646962</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Acute Disease ; Animals ; Antibodies ; Base Sequence ; Biological and medical sciences ; Biopsy ; Chronic Disease ; Chronic infection ; Enzymes ; Female ; Follow-Up Studies ; Genomes ; Hepacivirus - genetics ; Hepacivirus - growth & development ; Hepacivirus - immunology ; Hepatitis ; Hepatitis Antibodies - analysis ; Hepatitis C ; Hepatitis C - microbiology ; Human viral diseases ; Humans ; Hydrochloric acid ; Immunization ; Immunoassay ; Infections ; Infectious diseases ; Laboratories ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Non-A, non-B hepatitis ; Pan troglodytes ; Patients ; Phenols ; Polymerase Chain Reaction ; Primers ; Replication ; Ribonucleic acid ; RNA ; RNA, Viral - analysis ; Studies ; Time Factors ; Viral diseases ; Viral hepatitis ; Viremia ; Virus Replication ; Viruses</subject><ispartof>The New England journal of medicine, 1991-07, Vol.325 (2), p.98-104</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Jul 11, 1991</rights><rights>Copyright Massachusetts Medical Society, Publishing Division Jul 11, 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-97355e9160346a796d77b749b5552591dfa9d1801cd4cf1ee6d6e63d5215d5943</citedby><cites>FETCH-LOGICAL-c532t-97355e9160346a796d77b749b5552591dfa9d1801cd4cf1ee6d6e63d5215d5943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199107113250205$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223950693?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4966989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1646962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farci, Patrizia</creatorcontrib><creatorcontrib>Alter, Harvey J</creatorcontrib><creatorcontrib>Wong, Doris</creatorcontrib><creatorcontrib>Miller, Roger H</creatorcontrib><creatorcontrib>Shih, James W</creatorcontrib><creatorcontrib>Jett, Betsy</creatorcontrib><creatorcontrib>Purcell, Robert H</creatorcontrib><title>A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>THE genome of the hepatitis C virus (HCV), the etiologic agent of post-transfusion non-A, non-B hepatitis, was recently identified, and the products of viral genes were expressed in prokaryotic and eukaryotic systems.
1
Infection with HCV is routinely diagnosed by identifying in serum specific antibodies to these expressed proteins.
2
Several studies have shown a clear association between the presence of antibodies to HCV (anti-HCV) and chronic non-A, non-B hepatitis.
3
4
5
6
7
However, antibody testing cannot determine whether a patient with anti-HCV has recovered from the infection or is still carrying the virus and is potentially infectious. In addition, anti-HCV often appears late after . . .</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Chronic Disease</subject><subject>Chronic infection</subject><subject>Enzymes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genomes</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - growth & development</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis</subject><subject>Hepatitis Antibodies - analysis</subject><subject>Hepatitis C</subject><subject>Hepatitis C - microbiology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Hydrochloric acid</subject><subject>Immunization</subject><subject>Immunoassay</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Non-A, non-B hepatitis</subject><subject>Pan troglodytes</subject><subject>Patients</subject><subject>Phenols</subject><subject>Polymerase Chain Reaction</subject><subject>Primers</subject><subject>Replication</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viremia</subject><subject>Virus Replication</subject><subject>Viruses</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1vFDEMhiMEKtvCL0BIESAudGicxMn4uKxKC9oWqRSuo-wkg2Y1H0syc-i_72x31UoIqC-W7Mevbb2MvQLxEQSak8vTrxdABMICKIlCCnzCZoBKZVoL85TNhJB5pi2p5-wwpbWYAjQdsAMw2pCRM7ac82Xf_cquQ2z592H0N7yv-HnYuKEe6sQX_Gcdx8Svwqapy6nYd7zu-GXfZfPju_TpgX7BnlWuSeHlPh-xH59Prxfn2fLb2ZfFfJmVqOSQkVWIgcAIpY2zZLy1K6tphYgSCXzlyEMuoPS6rCAE400wyqME9EhaHbH3O91N7H-PIQ1FW6cyNI3rQj-mIhdGarT5o-D2BCstTuCbP8B1P8ZueqKQUhEKQ2qC3v4LAsqVVtbIrZTaUWXsU4qhKjaxbl28KUAUW9-Kv_g2Tb3ea4-rNviHmZ1RU__dvu9S6Zoquq6s0z2myRjKacI-7LC2TUUX1u1_l94CFGymVw</recordid><startdate>19910711</startdate><enddate>19910711</enddate><creator>Farci, Patrizia</creator><creator>Alter, Harvey J</creator><creator>Wong, Doris</creator><creator>Miller, Roger H</creator><creator>Shih, James W</creator><creator>Jett, Betsy</creator><creator>Purcell, Robert H</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19910711</creationdate><title>A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis</title><author>Farci, Patrizia ; Alter, Harvey J ; Wong, Doris ; Miller, Roger H ; Shih, James W ; Jett, Betsy ; Purcell, Robert H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-97355e9160346a796d77b749b5552591dfa9d1801cd4cf1ee6d6e63d5215d5943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Chronic Disease</topic><topic>Chronic infection</topic><topic>Enzymes</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genomes</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - growth & development</topic><topic>Hepacivirus - immunology</topic><topic>Hepatitis</topic><topic>Hepatitis Antibodies - analysis</topic><topic>Hepatitis C</topic><topic>Hepatitis C - microbiology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Hydrochloric acid</topic><topic>Immunization</topic><topic>Immunoassay</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Non-A, non-B hepatitis</topic><topic>Pan troglodytes</topic><topic>Patients</topic><topic>Phenols</topic><topic>Polymerase Chain Reaction</topic><topic>Primers</topic><topic>Replication</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viremia</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farci, Patrizia</creatorcontrib><creatorcontrib>Alter, Harvey J</creatorcontrib><creatorcontrib>Wong, Doris</creatorcontrib><creatorcontrib>Miller, Roger H</creatorcontrib><creatorcontrib>Shih, James W</creatorcontrib><creatorcontrib>Jett, Betsy</creatorcontrib><creatorcontrib>Purcell, Robert H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farci, Patrizia</au><au>Alter, Harvey J</au><au>Wong, Doris</au><au>Miller, Roger H</au><au>Shih, James W</au><au>Jett, Betsy</au><au>Purcell, Robert H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1991-07-11</date><risdate>1991</risdate><volume>325</volume><issue>2</issue><spage>98</spage><epage>104</epage><pages>98-104</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>THE genome of the hepatitis C virus (HCV), the etiologic agent of post-transfusion non-A, non-B hepatitis, was recently identified, and the products of viral genes were expressed in prokaryotic and eukaryotic systems.
1
Infection with HCV is routinely diagnosed by identifying in serum specific antibodies to these expressed proteins.
2
Several studies have shown a clear association between the presence of antibodies to HCV (anti-HCV) and chronic non-A, non-B hepatitis.
3
4
5
6
7
However, antibody testing cannot determine whether a patient with anti-HCV has recovered from the infection or is still carrying the virus and is potentially infectious. In addition, anti-HCV often appears late after . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>1646962</pmid><doi>10.1056/NEJM199107113250205</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1991-07, Vol.325 (2), p.98-104 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Acute Disease Animals Antibodies Base Sequence Biological and medical sciences Biopsy Chronic Disease Chronic infection Enzymes Female Follow-Up Studies Genomes Hepacivirus - genetics Hepacivirus - growth & development Hepacivirus - immunology Hepatitis Hepatitis Antibodies - analysis Hepatitis C Hepatitis C - microbiology Human viral diseases Humans Hydrochloric acid Immunization Immunoassay Infections Infectious diseases Laboratories Male Medical sciences Middle Aged Molecular Sequence Data Non-A, non-B hepatitis Pan troglodytes Patients Phenols Polymerase Chain Reaction Primers Replication Ribonucleic acid RNA RNA, Viral - analysis Studies Time Factors Viral diseases Viral hepatitis Viremia Virus Replication Viruses |
| title | A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis |
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