Clinical Correlates of Circulating Immune Complexes in Patients with Recent Yersiniosis
Circulating immune complexes (CICs) and rheumatoid factor were studied in 31 patients with serologically confirmed yersiniosis (12 in a pilot series and 19 in a prospective series). Yersiniosis is an intestinal infection complicated occasionally by extraintestinal symptoms such as aseptic arthritis....
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| Veröffentlicht in: | The Journal of infectious diseases 1983-08, Vol.148 (2), p.223-229 |
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| creator | Kekomäki, R. Granfors, K. Leino, R. Penttinen, K. Lindström, P.-L. Wager, O. |
| description | Circulating immune complexes (CICs) and rheumatoid factor were studied in 31 patients with serologically confirmed yersiniosis (12 in a pilot series and 19 in a prospective series). Yersiniosis is an intestinal infection complicated occasionally by extraintestinal symptoms such as aseptic arthritis. Four tests representing three main principles (affinity of human platelets and of Clq for complexed IgG and of conglutinin for C3) were used for the detection of CICs, which were found in all patients. Fifty-five of 62 specimens of serum from the prospective series of 19 patients reacted positively in at least one test. The conglutinin-binding assay and the platelet-125-I-labelcd staphylococcal protein A test gave positive results most frequently (74% and 84% of the time). Mean levels of CICs were significantly higher in patients with prolonged gastroenteritis than in those with histocompatibility leukocyte antigen B27-positive arthritis. During follow-up, the mean level of CICs (as measured by the platelet-protein A test) decreased significantly in patients with arthritis, while CICs and rheumatoid factor persisted in patients with prolonged gastroenteritis. |
| doi_str_mv | 10.1093/infdis/148.2.223 |
| format | Article |
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Yersiniosis is an intestinal infection complicated occasionally by extraintestinal symptoms such as aseptic arthritis. Four tests representing three main principles (affinity of human platelets and of Clq for complexed IgG and of conglutinin for C3) were used for the detection of CICs, which were found in all patients. Fifty-five of 62 specimens of serum from the prospective series of 19 patients reacted positively in at least one test. The conglutinin-binding assay and the platelet-125-I-labelcd staphylococcal protein A test gave positive results most frequently (74% and 84% of the time). Mean levels of CICs were significantly higher in patients with prolonged gastroenteritis than in those with histocompatibility leukocyte antigen B27-positive arthritis. During follow-up, the mean level of CICs (as measured by the platelet-protein A test) decreased significantly in patients with arthritis, while CICs and rheumatoid factor persisted in patients with prolonged gastroenteritis.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/148.2.223</identifier><identifier>PMID: 6604113</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Antibodies ; Antigen antibody complex ; Antigen-Antibody Complex - analysis ; Antigens ; Arthritis ; Arthritis - etiology ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Clinical Investigation ; Female ; Gastroenteritis ; HLA Antigens ; HLA-B27 Antigen ; Human bacterial diseases ; Humans ; Immunoglobulin A - analysis ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis ; Infections ; Infectious diseases ; Male ; Medical sciences ; Pipas ; Platelets ; Reactive arthritis ; Rheumatoid Factor - analysis ; Yersinia ; Yersinia enterocolitica ; Yersinia enterocolitica - immunology ; Yersinia Infections - complications ; Yersinia Infections - immunology</subject><ispartof>The Journal of infectious diseases, 1983-08, Vol.148 (2), p.223-229</ispartof><rights>Copyright 1983 The University of Chicago</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-793164879af4966577119e0a269e1d43324da49943d6689ffe825198330b41023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30089068$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30089068$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9575965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9597832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6604113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kekomäki, R.</creatorcontrib><creatorcontrib>Granfors, K.</creatorcontrib><creatorcontrib>Leino, R.</creatorcontrib><creatorcontrib>Penttinen, K.</creatorcontrib><creatorcontrib>Lindström, P.-L.</creatorcontrib><creatorcontrib>Wager, O.</creatorcontrib><title>Clinical Correlates of Circulating Immune Complexes in Patients with Recent Yersiniosis</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Circulating immune complexes (CICs) and rheumatoid factor were studied in 31 patients with serologically confirmed yersiniosis (12 in a pilot series and 19 in a prospective series). Yersiniosis is an intestinal infection complicated occasionally by extraintestinal symptoms such as aseptic arthritis. Four tests representing three main principles (affinity of human platelets and of Clq for complexed IgG and of conglutinin for C3) were used for the detection of CICs, which were found in all patients. Fifty-five of 62 specimens of serum from the prospective series of 19 patients reacted positively in at least one test. The conglutinin-binding assay and the platelet-125-I-labelcd staphylococcal protein A test gave positive results most frequently (74% and 84% of the time). Mean levels of CICs were significantly higher in patients with prolonged gastroenteritis than in those with histocompatibility leukocyte antigen B27-positive arthritis. During follow-up, the mean level of CICs (as measured by the platelet-protein A test) decreased significantly in patients with arthritis, while CICs and rheumatoid factor persisted in patients with prolonged gastroenteritis.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Antigen antibody complex</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Antigens</subject><subject>Arthritis</subject><subject>Arthritis - etiology</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Clinical Investigation</subject><subject>Female</subject><subject>Gastroenteritis</subject><subject>HLA Antigens</subject><subject>HLA-B27 Antigen</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pipas</subject><subject>Platelets</subject><subject>Reactive arthritis</subject><subject>Rheumatoid Factor - analysis</subject><subject>Yersinia</subject><subject>Yersinia enterocolitica</subject><subject>Yersinia enterocolitica - immunology</subject><subject>Yersinia Infections - complications</subject><subject>Yersinia Infections - immunology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq0KVLZL71yQckDcsvV4_HmECGilSrQV0I-L5SYOuORjaydq-fe42mU59jQaPc-8I72EvAG6AmrwKAxtE9IRcL1iK8ZwjyxAoCqlBHxBFpQyVoI25hU5SOmOUspRqn2yLyXlALggl1UXhlC7rqjGGH3nJp-KsS2qEOs5b2H4WZz0_Tz4LPTrzj9mHobiLCM_TKl4CNOv4sLXeSmufUw5bUwhvSYvW9clf7idS_L986dv1XF5-vXLSfXhtKw5x6lUBkFyrYxruZFSKAVgPHVMGg8NR2S8cdwYjo2U2rSt10yA0Yj0lgNluCTvN7nrON7PPk22D6n2XecGP87JaipzLQjPioBSgxYii3Qj1nFMKfrWrmPoXfxjgdqn0u2mdJtLt8w-pS_J2232fNv7ZnewbTnzd1vuUq66jW6oc8A_zQijNLLnNSWMFP-_3aVpjDuMlGpDpc683PCQJv-44y7-tlKhEvb46sZ-xPzyXPywZ_gXFfCuwQ</recordid><startdate>198308</startdate><enddate>198308</enddate><creator>Kekomäki, R.</creator><creator>Granfors, K.</creator><creator>Leino, R.</creator><creator>Penttinen, K.</creator><creator>Lindström, P.-L.</creator><creator>Wager, O.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198308</creationdate><title>Clinical Correlates of Circulating Immune Complexes in Patients with Recent Yersiniosis</title><author>Kekomäki, R. ; Granfors, K. ; Leino, R. ; Penttinen, K. ; Lindström, P.-L. ; Wager, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-793164879af4966577119e0a269e1d43324da49943d6689ffe825198330b41023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Antibodies</topic><topic>Antigen antibody complex</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Antigens</topic><topic>Arthritis</topic><topic>Arthritis - etiology</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Clinical Investigation</topic><topic>Female</topic><topic>Gastroenteritis</topic><topic>HLA Antigens</topic><topic>HLA-B27 Antigen</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pipas</topic><topic>Platelets</topic><topic>Reactive arthritis</topic><topic>Rheumatoid Factor - analysis</topic><topic>Yersinia</topic><topic>Yersinia enterocolitica</topic><topic>Yersinia enterocolitica - immunology</topic><topic>Yersinia Infections - complications</topic><topic>Yersinia Infections - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kekomäki, R.</creatorcontrib><creatorcontrib>Granfors, K.</creatorcontrib><creatorcontrib>Leino, R.</creatorcontrib><creatorcontrib>Penttinen, K.</creatorcontrib><creatorcontrib>Lindström, P.-L.</creatorcontrib><creatorcontrib>Wager, O.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kekomäki, R.</au><au>Granfors, K.</au><au>Leino, R.</au><au>Penttinen, K.</au><au>Lindström, P.-L.</au><au>Wager, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Correlates of Circulating Immune Complexes in Patients with Recent Yersiniosis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1983-08</date><risdate>1983</risdate><volume>148</volume><issue>2</issue><spage>223</spage><epage>229</epage><pages>223-229</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Circulating immune complexes (CICs) and rheumatoid factor were studied in 31 patients with serologically confirmed yersiniosis (12 in a pilot series and 19 in a prospective series). Yersiniosis is an intestinal infection complicated occasionally by extraintestinal symptoms such as aseptic arthritis. Four tests representing three main principles (affinity of human platelets and of Clq for complexed IgG and of conglutinin for C3) were used for the detection of CICs, which were found in all patients. Fifty-five of 62 specimens of serum from the prospective series of 19 patients reacted positively in at least one test. The conglutinin-binding assay and the platelet-125-I-labelcd staphylococcal protein A test gave positive results most frequently (74% and 84% of the time). Mean levels of CICs were significantly higher in patients with prolonged gastroenteritis than in those with histocompatibility leukocyte antigen B27-positive arthritis. During follow-up, the mean level of CICs (as measured by the platelet-protein A test) decreased significantly in patients with arthritis, while CICs and rheumatoid factor persisted in patients with prolonged gastroenteritis.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>6604113</pmid><doi>10.1093/infdis/148.2.223</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1983-08, Vol.148 (2), p.223-229 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Antibodies Antigen antibody complex Antigen-Antibody Complex - analysis Antigens Arthritis Arthritis - etiology Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Clinical Investigation Female Gastroenteritis HLA Antigens HLA-B27 Antigen Human bacterial diseases Humans Immunoglobulin A - analysis Immunoglobulin G - analysis Immunoglobulin M - analysis Infections Infectious diseases Male Medical sciences Pipas Platelets Reactive arthritis Rheumatoid Factor - analysis Yersinia Yersinia enterocolitica Yersinia enterocolitica - immunology Yersinia Infections - complications Yersinia Infections - immunology |
| title | Clinical Correlates of Circulating Immune Complexes in Patients with Recent Yersiniosis |
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