Correlation between the triggering of proliferation and the potentiation of NK activity induced by protein A in human lymphocytes
Various preparations of Staphylococci protein A (SpA) obtained either from strain Cowan-1 or strain A676 and two SpA low molecular fragments (AB and B) were tested for their mitogenic and NK-stimulating activity on human peripheral blood lymphocytes. Though all 4 preparations of SpA and both of its...
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| Veröffentlicht in: | Immunology letters 1983-04, Vol.6 (4), p.231-237 |
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| container_title | Immunology letters |
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| creator | Olinescu, A. Hristescu, Sanda Sjöquist, J. Ghetie, V. |
| description | Various preparations of Staphylococci protein A (SpA) obtained either from strain Cowan-1 or strain A676 and two SpA low molecular fragments (AB and B) were tested for their mitogenic and NK-stimulating activity on human peripheral blood lymphocytes.
Though all 4 preparations of SpA and both of its fragments were able to react with human IgG, apparently with both Fab and Fc sites of IgG, only the SpA preparations derived from A676 strain triggered the proliferation and potentiated the NK-activity of treated cells.
The parallelism between the mitogenic and NK-stimulating activities of SpA suggests that both activities might be under the control of the same portion of the SpA molecule located in the non-immunoglobulin binding region of the molecule. |
| doi_str_mv | 10.1016/0165-2478(83)90010-X |
| format | Article |
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Though all 4 preparations of SpA and both of its fragments were able to react with human IgG, apparently with both Fab and Fc sites of IgG, only the SpA preparations derived from A676 strain triggered the proliferation and potentiated the NK-activity of treated cells.
The parallelism between the mitogenic and NK-stimulating activities of SpA suggests that both activities might be under the control of the same portion of the SpA molecule located in the non-immunoglobulin binding region of the molecule.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/0165-2478(83)90010-X</identifier><identifier>PMID: 6885114</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Antigen-Antibody Complex - analysis ; Chemical Phenomena ; Chemistry, Physical ; Cytotoxicity, Immunologic ; Humans ; Killer Cells, Natural - immunology ; Lymphocyte Activation ; lymphocytes ; Lymphocytes - immunology ; mitogenicity ; Mitogens - pharmacology ; Molecular Weight ; NK-activity ; protein A ; Rabbits ; Staphylococcal Protein A - analysis ; Staphylococcal Protein A - classification ; Staphylococcal Protein A - pharmacology</subject><ispartof>Immunology letters, 1983-04, Vol.6 (4), p.231-237</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-ec74b734563ea4d465859c6429ad3757e9043507750a0389ae822e64437876c23</citedby><cites>FETCH-LOGICAL-c423t-ec74b734563ea4d465859c6429ad3757e9043507750a0389ae822e64437876c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-2478(83)90010-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6885114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olinescu, A.</creatorcontrib><creatorcontrib>Hristescu, Sanda</creatorcontrib><creatorcontrib>Sjöquist, J.</creatorcontrib><creatorcontrib>Ghetie, V.</creatorcontrib><title>Correlation between the triggering of proliferation and the potentiation of NK activity induced by protein A in human lymphocytes</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Various preparations of Staphylococci protein A (SpA) obtained either from strain Cowan-1 or strain A676 and two SpA low molecular fragments (AB and B) were tested for their mitogenic and NK-stimulating activity on human peripheral blood lymphocytes.
Though all 4 preparations of SpA and both of its fragments were able to react with human IgG, apparently with both Fab and Fc sites of IgG, only the SpA preparations derived from A676 strain triggered the proliferation and potentiated the NK-activity of treated cells.
The parallelism between the mitogenic and NK-stimulating activities of SpA suggests that both activities might be under the control of the same portion of the SpA molecule located in the non-immunoglobulin binding region of the molecule.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Cytotoxicity, Immunologic</subject><subject>Humans</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Activation</subject><subject>lymphocytes</subject><subject>Lymphocytes - immunology</subject><subject>mitogenicity</subject><subject>Mitogens - pharmacology</subject><subject>Molecular Weight</subject><subject>NK-activity</subject><subject>protein A</subject><subject>Rabbits</subject><subject>Staphylococcal Protein A - analysis</subject><subject>Staphylococcal Protein A - classification</subject><subject>Staphylococcal Protein A - pharmacology</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v3CAQhlHVKN2m_QetxKlKD07BgMGXStEqH1Wj5pJKuSEWz-5S2bAFnMrH_vPieJVjDwhp5nln4EHoAyUXlNDmSzmiqrlU54p9bgmhpHp8hVZUybYigtev0eoFeYPepvSrMIJxdopOG6UEpXyF_q5DjNCb7ILHG8h_ADzOe8A5ut0OovM7HLb4EEPvthAXzvjumTmEDD67pVioH9-xsdk9uTxh57vRQoc30xzO4Dy-LEW8HwfjcT8Nh32wU4b0Dp1sTZ_g_fE-Qz-vrx7Wt9Xd_c239eVdZXnNcgVW8o1kXDQMDO94I5RobcPr1nRMCgkt4UwQKQUxhKnWgKpraDhnUsnG1uwMfVrmluf8HiFlPbhkoe-NhzAmrUhTU9rOIF9AG0NKEbb6EN1g4qQp0bN5PWvVs1atmH42rx9L7ONx_rgZoHsJHVWX_telD-WTTw6iTtaBL45cBJt1F9z_F_wDPd6TlA</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Olinescu, A.</creator><creator>Hristescu, Sanda</creator><creator>Sjöquist, J.</creator><creator>Ghetie, V.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>Correlation between the triggering of proliferation and the potentiation of NK activity induced by protein A in human lymphocytes</title><author>Olinescu, A. ; Hristescu, Sanda ; Sjöquist, J. ; Ghetie, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-ec74b734563ea4d465859c6429ad3757e9043507750a0389ae822e64437876c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Cytotoxicity, Immunologic</topic><topic>Humans</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocyte Activation</topic><topic>lymphocytes</topic><topic>Lymphocytes - immunology</topic><topic>mitogenicity</topic><topic>Mitogens - pharmacology</topic><topic>Molecular Weight</topic><topic>NK-activity</topic><topic>protein A</topic><topic>Rabbits</topic><topic>Staphylococcal Protein A - analysis</topic><topic>Staphylococcal Protein A - classification</topic><topic>Staphylococcal Protein A - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olinescu, A.</creatorcontrib><creatorcontrib>Hristescu, Sanda</creatorcontrib><creatorcontrib>Sjöquist, J.</creatorcontrib><creatorcontrib>Ghetie, V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olinescu, A.</au><au>Hristescu, Sanda</au><au>Sjöquist, J.</au><au>Ghetie, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between the triggering of proliferation and the potentiation of NK activity induced by protein A in human lymphocytes</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>1983-04</date><risdate>1983</risdate><volume>6</volume><issue>4</issue><spage>231</spage><epage>237</epage><pages>231-237</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>Various preparations of Staphylococci protein A (SpA) obtained either from strain Cowan-1 or strain A676 and two SpA low molecular fragments (AB and B) were tested for their mitogenic and NK-stimulating activity on human peripheral blood lymphocytes.
Though all 4 preparations of SpA and both of its fragments were able to react with human IgG, apparently with both Fab and Fc sites of IgG, only the SpA preparations derived from A676 strain triggered the proliferation and potentiated the NK-activity of treated cells.
The parallelism between the mitogenic and NK-stimulating activities of SpA suggests that both activities might be under the control of the same portion of the SpA molecule located in the non-immunoglobulin binding region of the molecule.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6885114</pmid><doi>10.1016/0165-2478(83)90010-X</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 1983-04, Vol.6 (4), p.231-237 |
| issn | 0165-2478 1879-0542 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80621192 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals Antigen-Antibody Complex - analysis Chemical Phenomena Chemistry, Physical Cytotoxicity, Immunologic Humans Killer Cells, Natural - immunology Lymphocyte Activation lymphocytes Lymphocytes - immunology mitogenicity Mitogens - pharmacology Molecular Weight NK-activity protein A Rabbits Staphylococcal Protein A - analysis Staphylococcal Protein A - classification Staphylococcal Protein A - pharmacology |
| title | Correlation between the triggering of proliferation and the potentiation of NK activity induced by protein A in human lymphocytes |
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