Prolonged survival of experimental heart transplantation induced by theophylline
High levels of cyclic adenosine monophosphate (cAMP) in lymphocytes are associated with a reduction in many immunological functions. Theophylline, a drug effective in elevating lymphocyte cAMP levels, was employed as a single immunomodulator treatment in rats submitted to heterotopic heart allotrans...
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| Veröffentlicht in: | Immunology letters 1983-01, Vol.6 (5), p.247-250 |
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| container_title | Immunology letters |
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| creator | Rugarli, Claudio Marni, Antonio Ferrero, Maria Elena |
| description | High levels of cyclic adenosine monophosphate (cAMP) in lymphocytes are associated with a reduction in many immunological functions. Theophylline, a drug effective in elevating lymphocyte cAMP levels, was employed as a single immunomodulator treatment in rats submitted to heterotopic heart allotransplantation. In 3 strain combinations, the graft survival was consistently prolonged in treated animals in comparison with untreated controls. |
| doi_str_mv | 10.1016/0165-2478(83)90013-5 |
| format | Article |
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Theophylline, a drug effective in elevating lymphocyte cAMP levels, was employed as a single immunomodulator treatment in rats submitted to heterotopic heart allotransplantation. In 3 strain combinations, the graft survival was consistently prolonged in treated animals in comparison with untreated controls.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/0165-2478(83)90013-5</identifier><identifier>PMID: 6309655</identifier><identifier>CODEN: IMLED6</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Abdominal Neoplasms ; Aminophylline - administration & dosage ; Aminophylline - pharmacology ; Animals ; Biological and medical sciences ; Choristoma ; Cyclic AMP - biosynthesis ; Graft Survival - drug effects ; Heart Transplantation ; Hormones. Endocrine system ; immunosuppression ; Lymphocytes - metabolism ; Male ; Medical sciences ; Pharmacology. 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Theophylline, a drug effective in elevating lymphocyte cAMP levels, was employed as a single immunomodulator treatment in rats submitted to heterotopic heart allotransplantation. In 3 strain combinations, the graft survival was consistently prolonged in treated animals in comparison with untreated controls.</description><subject>Abdominal Neoplasms</subject><subject>Aminophylline - administration & dosage</subject><subject>Aminophylline - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Choristoma</subject><subject>Cyclic AMP - biosynthesis</subject><subject>Graft Survival - drug effects</subject><subject>Heart Transplantation</subject><subject>Hormones. Endocrine system</subject><subject>immunosuppression</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Lew</subject><subject>Rats, Inbred Strains</subject><subject>theophylline cAMP</subject><subject>transplantation</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVocJy0_yCBPZSSHLaRVh8rXQLFtE3AUB_Ss5Cl2VplvdpIuyb-95XrxcfkIAbNPO8wPAhdE_yVYCLu8-NlxWp5K-mdwpjQkp-hOZG1KjFn1Qc0PyEX6DKlv5nhlNEZmgmKleB8jlarGNrQ_QFXpDHu_M60RWgKeO0h-i10Q_5vwMShGKLpUt-a3Bp86ArfudHm2HpfDBsI_Wbftr6Dj-i8MW2CT1O9Qr9_fH9ePJbLXz-fFt-WpWWkHkqLLcbKGk5qSRUBunYVYU4K5yizjikD2EFVCbCKYVI3nDdOVUo4wSQTQK_Ql-PePoaXEdKgtz5ZaPOBEMakJRZEMonfBQmtOWZUZpAdQRtDShEa3WcFJu41wfpgXB906oNOLan-b1zzHLuZ9o_rLbhTaFKc55-nuUnWtE3WaH06YYpKLqs6Yw9HDLK0nYeok_XQZcM-gh20C_7tO_4BtiGdGg</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Rugarli, Claudio</creator><creator>Marni, Antonio</creator><creator>Ferrero, Maria Elena</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Prolonged survival of experimental heart transplantation induced by theophylline</title><author>Rugarli, Claudio ; Marni, Antonio ; Ferrero, Maria Elena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c0c009ca5178391e3bd214d86dd34cd49ae0de226ec94017f55fd9296d64846e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Abdominal Neoplasms</topic><topic>Aminophylline - administration & dosage</topic><topic>Aminophylline - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Choristoma</topic><topic>Cyclic AMP - biosynthesis</topic><topic>Graft Survival - drug effects</topic><topic>Heart Transplantation</topic><topic>Hormones. Endocrine system</topic><topic>immunosuppression</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Lew</topic><topic>Rats, Inbred Strains</topic><topic>theophylline cAMP</topic><topic>transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rugarli, Claudio</creatorcontrib><creatorcontrib>Marni, Antonio</creatorcontrib><creatorcontrib>Ferrero, Maria Elena</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rugarli, Claudio</au><au>Marni, Antonio</au><au>Ferrero, Maria Elena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged survival of experimental heart transplantation induced by theophylline</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>6</volume><issue>5</issue><spage>247</spage><epage>250</epage><pages>247-250</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><coden>IMLED6</coden><abstract>High levels of cyclic adenosine monophosphate (cAMP) in lymphocytes are associated with a reduction in many immunological functions. Theophylline, a drug effective in elevating lymphocyte cAMP levels, was employed as a single immunomodulator treatment in rats submitted to heterotopic heart allotransplantation. In 3 strain combinations, the graft survival was consistently prolonged in treated animals in comparison with untreated controls.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>6309655</pmid><doi>10.1016/0165-2478(83)90013-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 1983-01, Vol.6 (5), p.247-250 |
| issn | 0165-2478 1879-0542 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80618480 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Abdominal Neoplasms Aminophylline - administration & dosage Aminophylline - pharmacology Animals Biological and medical sciences Choristoma Cyclic AMP - biosynthesis Graft Survival - drug effects Heart Transplantation Hormones. Endocrine system immunosuppression Lymphocytes - metabolism Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred BN Rats, Inbred F344 Rats, Inbred Lew Rats, Inbred Strains theophylline cAMP transplantation |
| title | Prolonged survival of experimental heart transplantation induced by theophylline |
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