Inhibition of lipid peroxidation in spinal cord homogenates by various drugs
The extent and kinetic profiles of lipid peroxidation induced with Fe 2+-ascorbic acid in a homogenate of spinal cord from greyhound dogs were ascertained by measurement of the formation of malondialdehyde (MDA) and chemiluminescence in the presence of four drugs. Changes in MDA and chemiluminescenc...
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| Veröffentlicht in: | Experimental neurology 1983-01, Vol.81 (3), p.714-721 |
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| container_title | Experimental neurology |
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| creator | Misiorowski, Ronald L. Chvapil, Milos Snider, Betty J. Weinstein, Philip R. Vostal, Jaroslav J. |
| description | The extent and kinetic profiles of lipid peroxidation induced with Fe
2+-ascorbic acid in a homogenate of spinal cord from greyhound dogs were ascertained by measurement of the formation of malondialdehyde (MDA) and chemiluminescence in the presence of four drugs. Changes in MDA and chemiluminescence were correlated as a function of the activator or inhibitors. The kinetic profiles of chemiluminescence which were observed for 25 min after addition of the activator and individul inhibitors were similar regardless of the type of inhibitor studied. The most effective inhibition was by disulfiram which was approximately 11 and 33 times more effective than two other inhibitors, propyl gallate and promethazine, respectively, and 11,000 times more effective than
d-α-tocopherol. |
| doi_str_mv | 10.1016/0014-4886(83)90338-2 |
| format | Article |
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2+-ascorbic acid in a homogenate of spinal cord from greyhound dogs were ascertained by measurement of the formation of malondialdehyde (MDA) and chemiluminescence in the presence of four drugs. Changes in MDA and chemiluminescence were correlated as a function of the activator or inhibitors. The kinetic profiles of chemiluminescence which were observed for 25 min after addition of the activator and individul inhibitors were similar regardless of the type of inhibitor studied. The most effective inhibition was by disulfiram which was approximately 11 and 33 times more effective than two other inhibitors, propyl gallate and promethazine, respectively, and 11,000 times more effective than
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2+-ascorbic acid in a homogenate of spinal cord from greyhound dogs were ascertained by measurement of the formation of malondialdehyde (MDA) and chemiluminescence in the presence of four drugs. Changes in MDA and chemiluminescence were correlated as a function of the activator or inhibitors. The kinetic profiles of chemiluminescence which were observed for 25 min after addition of the activator and individul inhibitors were similar regardless of the type of inhibitor studied. The most effective inhibition was by disulfiram which was approximately 11 and 33 times more effective than two other inhibitors, propyl gallate and promethazine, respectively, and 11,000 times more effective than
d-α-tocopherol.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Disulfiram - pharmacology</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kinetics</subject><subject>Lipid Peroxides - metabolism</subject><subject>Luminescent Measurements</subject><subject>Malondialdehyde - biosynthesis</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Promethazine - pharmacology</subject><subject>Spinal Cord - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vitamin E - pharmacology</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVpSRy3_6ABHUpID5vqa3elSyCYJA0YcmnPQjuatVXWq620Nsm_zzo2PrYnwcwzMy-PCPnK2Q1nvPrBGFeF0rq61vK7YVLqQnwgM84MK4SS7COZnZBzcpHzH8aYUaI-I2eV1kppNiPLp34dmjCG2NPY0i4MwdMBU3wJ3r1XQ0_zEHrXUYjJ03XcxBX2bsRMm1e6cynEbaY-bVf5M_nUui7jl-M7J78f7n8tfhbL58enxd2yAMXrsWgAWoFgjKxcq9C0reacg2sUR6O0F2VZaYCaGyMk9zAlhRoE1I0T6Esh5-TqsHdI8e8W82g3IQN2netxCmM1q3ilyuq_IJf1dLnUE6gOIKSYc8LWDilsXHq1nNm9bbtXafcqrZb23bbdB7k87t82G_SnoaPeqf_t2HcZXNcm10PIJ8xIJfn0VXNye8BwkrYLmGyGgD2gDwlhtD6Gf-d4A1KUm3g</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Misiorowski, Ronald L.</creator><creator>Chvapil, Milos</creator><creator>Snider, Betty J.</creator><creator>Weinstein, Philip R.</creator><creator>Vostal, Jaroslav J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Inhibition of lipid peroxidation in spinal cord homogenates by various drugs</title><author>Misiorowski, Ronald L. ; Chvapil, Milos ; Snider, Betty J. ; Weinstein, Philip R. ; Vostal, Jaroslav J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-bccf2ec9936af4e9ff8111cab41e948d25568cc7199231dc448c7c2c7ba2ed523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Disulfiram - pharmacology</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kinetics</topic><topic>Lipid Peroxides - metabolism</topic><topic>Luminescent Measurements</topic><topic>Malondialdehyde - biosynthesis</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Promethazine - pharmacology</topic><topic>Spinal Cord - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Misiorowski, Ronald L.</creatorcontrib><creatorcontrib>Chvapil, Milos</creatorcontrib><creatorcontrib>Snider, Betty J.</creatorcontrib><creatorcontrib>Weinstein, Philip R.</creatorcontrib><creatorcontrib>Vostal, Jaroslav J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misiorowski, Ronald L.</au><au>Chvapil, Milos</au><au>Snider, Betty J.</au><au>Weinstein, Philip R.</au><au>Vostal, Jaroslav J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of lipid peroxidation in spinal cord homogenates by various drugs</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>81</volume><issue>3</issue><spage>714</spage><epage>721</epage><pages>714-721</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>The extent and kinetic profiles of lipid peroxidation induced with Fe
2+-ascorbic acid in a homogenate of spinal cord from greyhound dogs were ascertained by measurement of the formation of malondialdehyde (MDA) and chemiluminescence in the presence of four drugs. Changes in MDA and chemiluminescence were correlated as a function of the activator or inhibitors. The kinetic profiles of chemiluminescence which were observed for 25 min after addition of the activator and individul inhibitors were similar regardless of the type of inhibitor studied. The most effective inhibition was by disulfiram which was approximately 11 and 33 times more effective than two other inhibitors, propyl gallate and promethazine, respectively, and 11,000 times more effective than
d-α-tocopherol.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6884480</pmid><doi>10.1016/0014-4886(83)90338-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Experimental neurology, 1983-01, Vol.81 (3), p.714-721 |
| issn | 0014-4886 1090-2430 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Disulfiram - pharmacology Dogs Fundamental and applied biological sciences. Psychology Kinetics Lipid Peroxides - metabolism Luminescent Measurements Malondialdehyde - biosynthesis Oxidation-Reduction - drug effects Promethazine - pharmacology Spinal Cord - metabolism Vertebrates: nervous system and sense organs Vitamin E - pharmacology |
| title | Inhibition of lipid peroxidation in spinal cord homogenates by various drugs |
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