Gene duplication in bovine brain myelin proteolipid and homology with related proteins
Analysis of the amino acid sequence of bovine brain myelin proteolipid reveals not only extensive internal homology, but also homology with portions of the myelin basic protein, the peripheral nerve myelin protein, Po, and with the small proteolipid subunit of mitochondrial ATP synthase. These resul...
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| Veröffentlicht in: | FEBS letters 1983-09, Vol.161 (1), p.71-74 |
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| creator | Laursen, Richard A. Samiullah, Mohammed Lees, Marjorie B. |
| description | Analysis of the amino acid sequence of bovine brain myelin proteolipid reveals not only extensive internal homology, but also homology with portions of the myelin basic protein, the peripheral nerve myelin protein, Po, and with the small proteolipid subunit of mitochondrial ATP synthase. These results suggest that the myelin proteolipid gene has been constructed from a small number of genetic elements, and that these elements are also found in non-myelin proteins. Furthermore, the proteolipid appears to have evolved by acquisition of elements from a ‘gene pool’ over a period of time, rather than by a simple duplication mechanism. |
| doi_str_mv | 10.1016/0014-5793(83)80732-7 |
| format | Article |
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Genome</subject><subject>membrane glycoproteins</subject><subject>Membrane protein</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>myelin</subject><subject>Myelin basic protein</subject><subject>Myelin proteolipid</subject><subject>Myelin Sheath - metabolism</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Po glycoprotein</subject><subject>Proteolipids - genetics</subject><subject>Structure-Activity Relationship</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EKtvCPwApB4TgEPDEiTO5IEHVLUiVuABXy7En1MiJFzvbav89TrPaIyCPNJqZZz78MvYC-DvgIN9zDnXZtJ14g-It8lZUZfuIbQBbUYpa4mO2OSFP2XlKv3iOEbozdiYR60bwDftxTRMVdr_zzujZhalwU9GHO5ezfdQ5GA_ks9vFMFPwbudsoSdb3IYx-PDzUNy7-baI5PVMdqXclJ6xJ4P2iZ4f_QX7vr36dvm5vPl6_eXy401p6nxxCQQyv3YwgFyAkAga2nyclSibxmjZWGN6g_2gEQF1D_WgZS-HyoBEIy7Y63VuXvx7T2lWo0uGvNcThX1SyCVAV4l_gnl3V3eSZ7BeQRNDSpEGtYtu1PGggKtFd7WIqhZRFWZbdFdtbnt5nL_vR7KnpqPQuf7qWNfJaD9EPRmXTlgnGmgqmbHtit07T4f_Wq22V5-qpbDkUTxkl3s-rIMoq3_nKKpkHE2GrItkZmWD-_uH_gDonbG0</recordid><startdate>19830905</startdate><enddate>19830905</enddate><creator>Laursen, Richard A.</creator><creator>Samiullah, Mohammed</creator><creator>Lees, Marjorie B.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19830905</creationdate><title>Gene duplication in bovine brain myelin proteolipid and homology with related proteins</title><author>Laursen, Richard A. ; Samiullah, Mohammed ; Lees, Marjorie B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4807-1e161617fc180313681a17688d68655ca65dccbc8bfa8818ab14fa6b6f2c168c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>ATP synthase</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cattle</topic><topic>evolution</topic><topic>Fundamental and applied biological sciences. 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Genome</topic><topic>membrane glycoproteins</topic><topic>Membrane protein</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>myelin</topic><topic>Myelin basic protein</topic><topic>Myelin proteolipid</topic><topic>Myelin Sheath - metabolism</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Po glycoprotein</topic><topic>Proteolipids - genetics</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laursen, Richard A.</creatorcontrib><creatorcontrib>Samiullah, Mohammed</creatorcontrib><creatorcontrib>Lees, Marjorie B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laursen, Richard A.</au><au>Samiullah, Mohammed</au><au>Lees, Marjorie B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene duplication in bovine brain myelin proteolipid and homology with related proteins</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1983-09-05</date><risdate>1983</risdate><volume>161</volume><issue>1</issue><spage>71</spage><epage>74</epage><pages>71-74</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Analysis of the amino acid sequence of bovine brain myelin proteolipid reveals not only extensive internal homology, but also homology with portions of the myelin basic protein, the peripheral nerve myelin protein, Po, and with the small proteolipid subunit of mitochondrial ATP synthase. 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| ispartof | FEBS letters, 1983-09, Vol.161 (1), p.71-74 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals ATP synthase Biological and medical sciences Brain - metabolism Cattle evolution Fundamental and applied biological sciences. Psychology Gene duplication Genes Genes. Genome membrane glycoproteins Membrane protein Molecular and cellular biology Molecular genetics myelin Myelin basic protein Myelin proteolipid Myelin Sheath - metabolism Nerve Tissue Proteins - genetics Po glycoprotein Proteolipids - genetics Structure-Activity Relationship |
| title | Gene duplication in bovine brain myelin proteolipid and homology with related proteins |
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