Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists
The non-peptidic angiotensin II receptor subtype selective antagonists, DuP 753 and PD123177, were used to characterize angiotensin II receptor binding sites in the rat brain. Competitive receptor autoradiography with 125I-Sar 1-Ile 8 angiotensin II defined a regional distribution of binding sites t...
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| Veröffentlicht in: | Regulatory peptides 1991-03, Vol.33 (1), p.45-53 |
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| container_title | Regulatory peptides |
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| creator | Rowe, Brian P. Grove, Kevin L. Saylor, David L. Speth, Robert C. |
| description | The non-peptidic angiotensin II receptor subtype selective antagonists, DuP 753 and PD123177, were used to characterize angiotensin II receptor binding sites in the rat brain. Competitive receptor autoradiography with
125I-Sar
1-Ile
8 angiotensin II defined a regional distribution of binding sites that were sensitive to either DuP 753 (designated AII
α subtype) or PD123177 (designated AII
β subtype). Whereas most brain nuclei could be assigned to a category containing a predominant subtype, a multiple receptor subtype analysis indicated that some regions are homogeneous, while others contain a mixture of both AII
α and AII
β subtypes. |
| doi_str_mv | 10.1016/0167-0115(91)90014-8 |
| format | Article |
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125I-Sar
1-Ile
8 angiotensin II defined a regional distribution of binding sites that were sensitive to either DuP 753 (designated AII
α subtype) or PD123177 (designated AII
β subtype). Whereas most brain nuclei could be assigned to a category containing a predominant subtype, a multiple receptor subtype analysis indicated that some regions are homogeneous, while others contain a mixture of both AII
α and AII
β subtypes.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(91)90014-8</identifier><identifier>PMID: 2047544</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Angiotensin II - metabolism ; Angiotensin II receptor ; Angiotensin Receptor Antagonists ; Animals ; Binding, Competitive ; Biological and medical sciences ; Brain - metabolism ; Brain Chemistry - drug effects ; Cell Nucleus - drug effects ; Cell Nucleus - metabolism ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; DuP 753 ; Fundamental and applied biological sciences. Psychology ; Imidazoles - pharmacology ; Losartan ; Male ; PD123177 ; Pyridines - pharmacology ; Rat brain ; Rats ; Rats, Inbred Strains ; Receptor autoradiography ; Receptor subtype ; Receptors, Angiotensin - classification ; Receptors, Angiotensin - metabolism ; Tetrazoles - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Regulatory peptides, 1991-03, Vol.33 (1), p.45-53</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-50351f89132ba904ce362ecd903041235fd6c1ec01110b538e767c86d67c58863</citedby><cites>FETCH-LOGICAL-c302t-50351f89132ba904ce362ecd903041235fd6c1ec01110b538e767c86d67c58863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0167-0115(91)90014-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19570901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2047544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rowe, Brian P.</creatorcontrib><creatorcontrib>Grove, Kevin L.</creatorcontrib><creatorcontrib>Saylor, David L.</creatorcontrib><creatorcontrib>Speth, Robert C.</creatorcontrib><title>Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>The non-peptidic angiotensin II receptor subtype selective antagonists, DuP 753 and PD123177, were used to characterize angiotensin II receptor binding sites in the rat brain. Competitive receptor autoradiography with
125I-Sar
1-Ile
8 angiotensin II defined a regional distribution of binding sites that were sensitive to either DuP 753 (designated AII
α subtype) or PD123177 (designated AII
β subtype). Whereas most brain nuclei could be assigned to a category containing a predominant subtype, a multiple receptor subtype analysis indicated that some regions are homogeneous, while others contain a mixture of both AII
α and AII
β subtypes.</description><subject>Angiotensin II - metabolism</subject><subject>Angiotensin II receptor</subject><subject>Angiotensin Receptor Antagonists</subject><subject>Animals</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain Chemistry - drug effects</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>DuP 753</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Imidazoles - pharmacology</subject><subject>Losartan</subject><subject>Male</subject><subject>PD123177</subject><subject>Pyridines - pharmacology</subject><subject>Rat brain</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptor autoradiography</subject><subject>Receptor subtype</subject><subject>Receptors, Angiotensin - classification</subject><subject>Receptors, Angiotensin - metabolism</subject><subject>Tetrazoles - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9vFCEYh4nRtGv1G2jCRWMPo7zD8GcuTZpqdZMmXvRMGOadFbMLU2Da9NvLdjftzQMQwvP7hfch5B2wz8BAfqlLNQxAfOrhvGcMuka_ICvQijcgtXxJVk_IKXmd89_KCKX4CTlpWadE163I_VefXfI7H2zxMdA4URs2PhYM2Qe6XtOEDucSE83LUB5mpKPPJflheeQrU_4gTbbQIdl6W2psQ0MMzVxjfvTuucGGYjcx1Hx-Q15Ndpvx7fE8I7-vv_26-tHc_Py-vrq8aRxnbWkE4wIm3QNvB9uzziGXLbqxZ5x10HIxjdIBujojsEFwjUoqp-VYd6G15Gfk46F3TvF2wVzMrg6M260NGJdsNJMAquMV7A6gSzHnhJOZqxabHgwws_dt9jLNXqbpwTz6NrrG3h_7l2GH41PoKLi-fzi-2-zsdko2OJ-fu3uhWM-gchcHDquMO4_JZOcxOBx91VfMGP3_P_IP5wmdFA</recordid><startdate>19910326</startdate><enddate>19910326</enddate><creator>Rowe, Brian P.</creator><creator>Grove, Kevin L.</creator><creator>Saylor, David L.</creator><creator>Speth, Robert C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910326</creationdate><title>Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists</title><author>Rowe, Brian P. ; Grove, Kevin L. ; Saylor, David L. ; Speth, Robert C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-50351f89132ba904ce362ecd903041235fd6c1ec01110b538e767c86d67c58863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Angiotensin II - metabolism</topic><topic>Angiotensin II receptor</topic><topic>Angiotensin Receptor Antagonists</topic><topic>Animals</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain Chemistry - drug effects</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - metabolism</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>DuP 753</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Imidazoles - pharmacology</topic><topic>Losartan</topic><topic>Male</topic><topic>PD123177</topic><topic>Pyridines - pharmacology</topic><topic>Rat brain</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptor autoradiography</topic><topic>Receptor subtype</topic><topic>Receptors, Angiotensin - classification</topic><topic>Receptors, Angiotensin - metabolism</topic><topic>Tetrazoles - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rowe, Brian P.</creatorcontrib><creatorcontrib>Grove, Kevin L.</creatorcontrib><creatorcontrib>Saylor, David L.</creatorcontrib><creatorcontrib>Speth, Robert C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rowe, Brian P.</au><au>Grove, Kevin L.</au><au>Saylor, David L.</au><au>Speth, Robert C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1991-03-26</date><risdate>1991</risdate><volume>33</volume><issue>1</issue><spage>45</spage><epage>53</epage><pages>45-53</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>The non-peptidic angiotensin II receptor subtype selective antagonists, DuP 753 and PD123177, were used to characterize angiotensin II receptor binding sites in the rat brain. Competitive receptor autoradiography with
125I-Sar
1-Ile
8 angiotensin II defined a regional distribution of binding sites that were sensitive to either DuP 753 (designated AII
α subtype) or PD123177 (designated AII
β subtype). Whereas most brain nuclei could be assigned to a category containing a predominant subtype, a multiple receptor subtype analysis indicated that some regions are homogeneous, while others contain a mixture of both AII
α and AII
β subtypes.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2047544</pmid><doi>10.1016/0167-0115(91)90014-8</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-0115 |
| ispartof | Regulatory peptides, 1991-03, Vol.33 (1), p.45-53 |
| issn | 0167-0115 1873-1686 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angiotensin II - metabolism Angiotensin II receptor Angiotensin Receptor Antagonists Animals Binding, Competitive Biological and medical sciences Brain - metabolism Brain Chemistry - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors DuP 753 Fundamental and applied biological sciences. Psychology Imidazoles - pharmacology Losartan Male PD123177 Pyridines - pharmacology Rat brain Rats Rats, Inbred Strains Receptor autoradiography Receptor subtype Receptors, Angiotensin - classification Receptors, Angiotensin - metabolism Tetrazoles - pharmacology Vertebrates: nervous system and sense organs |
| title | Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists |
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