Estimating Relative Potency Using Prior Information

Estimating Relative Potency Using Prior Information

This paper exhibits a closed-form point and interval estimator of the log relative potency that incorporates prior information on the log relative potency in a symmetric parallel line bioassay. The point estimator turns out to be a weighted average of the usual estimator and the prior mean where the...

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Veröffentlicht in:Biometrics 1991-03, Vol.47 (1), p.295-301
Hauptverfasser: Kim, P. T., Carter, E. M., Hubert, J. J.
Format: Artikel
Sprache:eng
Schlagworte:
Bioassay
Biological and medical sciences
Biological Assay - statistics & numerical data
Biometrics
Biometry
Estimators
Estimators for the mean
Fundamental and applied biological sciences. Psychology
General aspects
Interval estimators
Models, Statistical
Parallel lines
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - standards
Point estimators
Shorter Communications
Statistical variance
Test preparation
Weighted averages
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Beschreibung
Zusammenfassung:This paper exhibits a closed-form point and interval estimator of the log relative potency that incorporates prior information on the log relative potency in a symmetric parallel line bioassay. The point estimator turns out to be a weighted average of the usual estimator and the prior mean where the weights are determined by the prior variance.
ISSN:0006-341X
1541-0420
DOI:10.2307/2532514