Antibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in Hemophiliacs
Along with homosexual men, Haitians, and intravenous drug abusers, hemophiliacs are at high risk of contracting acquired immunodeficiency syndrome (AIDS). An earlier study revealed that 36 percent of a group of the AIDS patients had antibodies to cell membrane antigens associated with the human T-ce...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1983-09, Vol.221 (4615), p.1061-1064 |
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| container_issue | 4615 |
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| container_volume | 221 |
| creator | Essex, M. McLane, M. F. Lee, T. H. Tachibana, N. Mullins, J. I. Kreiss, J. Kasper, C. K. M.-C. Poon Landay, A. Stein, S. F. Francis, D. P. Cabradilla, C. Lawrence, D. N. Evatt, B. L. |
| description | Along with homosexual men, Haitians, and intravenous drug abusers, hemophiliacs are at high risk of contracting acquired immunodeficiency syndrome (AIDS). An earlier study revealed that 36 percent of a group of the AIDS patients had antibodies to cell membrane antigens associated with the human T-cell leukemia virus (HTLV-MA), whereas only 1.2 percent of matched asymptomatic homosexual controls had these antibodies. In the present experiments, serum samples from 172 asymptomatic hemophiliacs were examined for the presence of antibodies to HTLV-MA. Such antibodies were detected in 5 to 19 percent of the hemophiliacs examined from four geographical locations, but in only 1 percent or less of laboratory workers, normal blood donors, donors on hemodialysis, or donors with chronic active hepatitis. |
| doi_str_mv | 10.1126/science.6603659 |
| format | Article |
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F. ; Lee, T. H. ; Tachibana, N. ; Mullins, J. I. ; Kreiss, J. ; Kasper, C. K. ; M.-C. Poon ; Landay, A. ; Stein, S. F. ; Francis, D. P. ; Cabradilla, C. ; Lawrence, D. N. ; Evatt, B. L.</creator><creatorcontrib>Essex, M. ; McLane, M. F. ; Lee, T. H. ; Tachibana, N. ; Mullins, J. I. ; Kreiss, J. ; Kasper, C. K. ; M.-C. Poon ; Landay, A. ; Stein, S. F. ; Francis, D. P. ; Cabradilla, C. ; Lawrence, D. N. ; Evatt, B. L.</creatorcontrib><description>Along with homosexual men, Haitians, and intravenous drug abusers, hemophiliacs are at high risk of contracting acquired immunodeficiency syndrome (AIDS). An earlier study revealed that 36 percent of a group of the AIDS patients had antibodies to cell membrane antigens associated with the human T-cell leukemia virus (HTLV-MA), whereas only 1.2 percent of matched asymptomatic homosexual controls had these antibodies. In the present experiments, serum samples from 172 asymptomatic hemophiliacs were examined for the presence of antibodies to HTLV-MA. Such antibodies were detected in 5 to 19 percent of the hemophiliacs examined from four geographical locations, but in only 1 percent or less of laboratory workers, normal blood donors, donors on hemodialysis, or donors with chronic active hepatitis.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6603659</identifier><identifier>PMID: 6603659</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>AIDS ; AIDS (Disease) ; AIDS research ; AIDS/HIV ; Antibodies ; Antibodies, Viral - analysis ; antibody response ; Antigens ; Antigens, Surface - immunology ; Antigens, Viral - immunology ; Biological and medical sciences ; Blood ; Blood donation ; Cell membranes ; Hematologic and hematopoietic diseases ; Hemophilia ; Hemophilia A - immunology ; Hemophilia A - microbiology ; Humans ; Immunologic research ; Immunological research ; Intramuscular injections ; Leukemia - microbiology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; man ; Medical sciences ; Reactivity ; Retroviridae - immunology ; T cell leukemia ; T cell leukemia virus ; T-Lymphocytes ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1983-09, Vol.221 (4615), p.1061-1064</ispartof><rights>Copyright 1983 The American Association for the Advancement of Science</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-185a88f76941e89db3e56ed2d250421a79cecb172c569a12ffdd1fe6d6563763</citedby><cites>FETCH-LOGICAL-c440t-185a88f76941e89db3e56ed2d250421a79cecb172c569a12ffdd1fe6d6563763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1691537$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1691537$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9679359$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6603659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Essex, M.</creatorcontrib><creatorcontrib>McLane, M. F.</creatorcontrib><creatorcontrib>Lee, T. H.</creatorcontrib><creatorcontrib>Tachibana, N.</creatorcontrib><creatorcontrib>Mullins, J. I.</creatorcontrib><creatorcontrib>Kreiss, J.</creatorcontrib><creatorcontrib>Kasper, C. K.</creatorcontrib><creatorcontrib>M.-C. Poon</creatorcontrib><creatorcontrib>Landay, A.</creatorcontrib><creatorcontrib>Stein, S. F.</creatorcontrib><creatorcontrib>Francis, D. P.</creatorcontrib><creatorcontrib>Cabradilla, C.</creatorcontrib><creatorcontrib>Lawrence, D. N.</creatorcontrib><creatorcontrib>Evatt, B. L.</creatorcontrib><title>Antibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in Hemophiliacs</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Along with homosexual men, Haitians, and intravenous drug abusers, hemophiliacs are at high risk of contracting acquired immunodeficiency syndrome (AIDS). An earlier study revealed that 36 percent of a group of the AIDS patients had antibodies to cell membrane antigens associated with the human T-cell leukemia virus (HTLV-MA), whereas only 1.2 percent of matched asymptomatic homosexual controls had these antibodies. In the present experiments, serum samples from 172 asymptomatic hemophiliacs were examined for the presence of antibodies to HTLV-MA. Such antibodies were detected in 5 to 19 percent of the hemophiliacs examined from four geographical locations, but in only 1 percent or less of laboratory workers, normal blood donors, donors on hemodialysis, or donors with chronic active hepatitis.</description><subject>AIDS</subject><subject>AIDS (Disease)</subject><subject>AIDS research</subject><subject>AIDS/HIV</subject><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>antibody response</subject><subject>Antigens</subject><subject>Antigens, Surface - immunology</subject><subject>Antigens, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood donation</subject><subject>Cell membranes</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemophilia</subject><subject>Hemophilia A - immunology</subject><subject>Hemophilia A - microbiology</subject><subject>Humans</subject><subject>Immunologic research</subject><subject>Immunological research</subject><subject>Intramuscular injections</subject><subject>Leukemia - microbiology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>man</subject><subject>Medical sciences</subject><subject>Reactivity</subject><subject>Retroviridae - immunology</subject><subject>T cell leukemia</subject><subject>T cell leukemia virus</subject><subject>T-Lymphocytes</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFr3DAQhUVpSDdpz720oEMJCcEbjWVJ1nFZkmxgw162uQpZHm-V2tbWsqH59_V2TXLMaWDeNzOPN4R8BTYHSOVNdB5bh3MpGZdCfyAzYFokOmX8I5mxsZnkTIlP5CzGZ8ZGTfNTcjrhM_Jz0fa-CKXHSPtAV0NjW7pNlljXdI3Db2y8pU--GyJ9xKbobIv0MLLDNtLL1Xb9lDwurqhv6QqbsP_la29d_ExOKltH_DLVc7K9u90uV8l6c_-wXKwTl2WsTyAXNs8rJXUGmOuy4CgklmmZCpalYJV26ApQqRNSW0irqiyhQllKIbmS_JxcHNfuu_BnwNibxkc3Wh9dhiGanEmWSZW9CwJXAMAPG6-P4M7WaHzrQtvj396FusYdmtH8cmMWqQaZZ3ykb46060KMHVZm3_nGdi8GmDm8x0zvMVPe48T3ychQNFi-8m_6j0m30dm6GvN2Pr5iWirN_2Pfjthz7EP3dlVqEFzxf5sWn_w</recordid><startdate>19830909</startdate><enddate>19830909</enddate><creator>Essex, M.</creator><creator>McLane, M. F.</creator><creator>Lee, T. H.</creator><creator>Tachibana, N.</creator><creator>Mullins, J. I.</creator><creator>Kreiss, J.</creator><creator>Kasper, C. K.</creator><creator>M.-C. Poon</creator><creator>Landay, A.</creator><creator>Stein, S. F.</creator><creator>Francis, D. P.</creator><creator>Cabradilla, C.</creator><creator>Lawrence, D. N.</creator><creator>Evatt, B. L.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19830909</creationdate><title>Antibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in Hemophiliacs</title><author>Essex, M. ; McLane, M. F. ; Lee, T. H. ; Tachibana, N. ; Mullins, J. I. ; Kreiss, J. ; Kasper, C. K. ; M.-C. Poon ; Landay, A. ; Stein, S. F. ; Francis, D. P. ; Cabradilla, C. ; Lawrence, D. N. ; Evatt, B. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-185a88f76941e89db3e56ed2d250421a79cecb172c569a12ffdd1fe6d6563763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>AIDS</topic><topic>AIDS (Disease)</topic><topic>AIDS research</topic><topic>AIDS/HIV</topic><topic>Antibodies</topic><topic>Antibodies, Viral - analysis</topic><topic>antibody response</topic><topic>Antigens</topic><topic>Antigens, Surface - immunology</topic><topic>Antigens, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood donation</topic><topic>Cell membranes</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemophilia</topic><topic>Hemophilia A - immunology</topic><topic>Hemophilia A - microbiology</topic><topic>Humans</topic><topic>Immunologic research</topic><topic>Immunological research</topic><topic>Intramuscular injections</topic><topic>Leukemia - microbiology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>man</topic><topic>Medical sciences</topic><topic>Reactivity</topic><topic>Retroviridae - immunology</topic><topic>T cell leukemia</topic><topic>T cell leukemia virus</topic><topic>T-Lymphocytes</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Essex, M.</creatorcontrib><creatorcontrib>McLane, M. F.</creatorcontrib><creatorcontrib>Lee, T. H.</creatorcontrib><creatorcontrib>Tachibana, N.</creatorcontrib><creatorcontrib>Mullins, J. I.</creatorcontrib><creatorcontrib>Kreiss, J.</creatorcontrib><creatorcontrib>Kasper, C. K.</creatorcontrib><creatorcontrib>M.-C. Poon</creatorcontrib><creatorcontrib>Landay, A.</creatorcontrib><creatorcontrib>Stein, S. F.</creatorcontrib><creatorcontrib>Francis, D. P.</creatorcontrib><creatorcontrib>Cabradilla, C.</creatorcontrib><creatorcontrib>Lawrence, D. N.</creatorcontrib><creatorcontrib>Evatt, B. L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Essex, M.</au><au>McLane, M. F.</au><au>Lee, T. H.</au><au>Tachibana, N.</au><au>Mullins, J. I.</au><au>Kreiss, J.</au><au>Kasper, C. K.</au><au>M.-C. Poon</au><au>Landay, A.</au><au>Stein, S. F.</au><au>Francis, D. P.</au><au>Cabradilla, C.</au><au>Lawrence, D. N.</au><au>Evatt, B. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in Hemophiliacs</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1983-09-09</date><risdate>1983</risdate><volume>221</volume><issue>4615</issue><spage>1061</spage><epage>1064</epage><pages>1061-1064</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Along with homosexual men, Haitians, and intravenous drug abusers, hemophiliacs are at high risk of contracting acquired immunodeficiency syndrome (AIDS). An earlier study revealed that 36 percent of a group of the AIDS patients had antibodies to cell membrane antigens associated with the human T-cell leukemia virus (HTLV-MA), whereas only 1.2 percent of matched asymptomatic homosexual controls had these antibodies. In the present experiments, serum samples from 172 asymptomatic hemophiliacs were examined for the presence of antibodies to HTLV-MA. Such antibodies were detected in 5 to 19 percent of the hemophiliacs examined from four geographical locations, but in only 1 percent or less of laboratory workers, normal blood donors, donors on hemodialysis, or donors with chronic active hepatitis.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>6603659</pmid><doi>10.1126/science.6603659</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1983-09, Vol.221 (4615), p.1061-1064 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80604674 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | AIDS AIDS (Disease) AIDS research AIDS/HIV Antibodies Antibodies, Viral - analysis antibody response Antigens Antigens, Surface - immunology Antigens, Viral - immunology Biological and medical sciences Blood Blood donation Cell membranes Hematologic and hematopoietic diseases Hemophilia Hemophilia A - immunology Hemophilia A - microbiology Humans Immunologic research Immunological research Intramuscular injections Leukemia - microbiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis man Medical sciences Reactivity Retroviridae - immunology T cell leukemia T cell leukemia virus T-Lymphocytes Viruses |
| title | Antibodies to Human T-Cell Leukemia Virus Membrane Antigens (HTLV-MA) in Hemophiliacs |
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