High affinity binding of the mastoparans by calmodulin
Calmodulin exhibits high affinity, calcium-dependent binding of the mastoparans — a group of cytoactive tetradecapeptides. The dissociation constants for the peptide-calmodulin complexes determined in 0.20 N KCl, 1.0 mM CaCl 2, pH 7.3 are ∼0.3 nM for mastoparan, ∼0.9 nM for mastoparan X, and ∼3.5 nM...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1983-07, Vol.114 (1), p.50-56 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Malencik, Dean A. Anderson, Sonia R. |
| description | Calmodulin exhibits high affinity, calcium-dependent binding of the mastoparans — a group of cytoactive tetradecapeptides. The dissociation constants for the peptide-calmodulin complexes determined in 0.20 N KCl, 1.0 mM CaCl
2, pH 7.3 are ∼0.3 nM for mastoparan, ∼0.9 nM for mastoparan X, and ∼3.5 nM for
Polistes
mastoparan. The dissociation constant for the mastoparan-calmodulin complex is the smallest known for any calmodulin binding protein or peptide, suggesting that some type of peptide-calmodulin interaction could be physiologically significant. |
| doi_str_mv | 10.1016/0006-291X(83)91592-9 |
| format | Article |
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2, pH 7.3 are ∼0.3 nM for mastoparan, ∼0.9 nM for mastoparan X, and ∼3.5 nM for
Polistes
mastoparan. The dissociation constant for the mastoparan-calmodulin complex is the smallest known for any calmodulin binding protein or peptide, suggesting that some type of peptide-calmodulin interaction could be physiologically significant.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(83)91592-9</identifier><identifier>PMID: 6688348</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Bee Venoms - metabolism ; Calcium-Binding Proteins - metabolism ; calmodulin ; Calmodulin - metabolism ; mastoparan ; Myosin-Light-Chain Kinase ; Oligopeptides - metabolism ; Peptides ; Protein Binding ; Protein Kinases - metabolism ; Rabbits ; Structure-Activity Relationship ; Swine ; Troponin - metabolism ; Troponin I ; Turkeys ; Wasp Venoms - metabolism</subject><ispartof>Biochemical and biophysical research communications, 1983-07, Vol.114 (1), p.50-56</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-f904b64b1410f10ff87a569d104db6cd710fb3872c6f2e2f20de2ebeae3195883</citedby><cites>FETCH-LOGICAL-c454t-f904b64b1410f10ff87a569d104db6cd710fb3872c6f2e2f20de2ebeae3195883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(83)91592-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6688348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malencik, Dean A.</creatorcontrib><creatorcontrib>Anderson, Sonia R.</creatorcontrib><title>High affinity binding of the mastoparans by calmodulin</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Calmodulin exhibits high affinity, calcium-dependent binding of the mastoparans — a group of cytoactive tetradecapeptides. The dissociation constants for the peptide-calmodulin complexes determined in 0.20 N KCl, 1.0 mM CaCl
2, pH 7.3 are ∼0.3 nM for mastoparan, ∼0.9 nM for mastoparan X, and ∼3.5 nM for
Polistes
mastoparan. The dissociation constant for the mastoparan-calmodulin complex is the smallest known for any calmodulin binding protein or peptide, suggesting that some type of peptide-calmodulin interaction could be physiologically significant.</description><subject>Animals</subject><subject>Bee Venoms - metabolism</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>calmodulin</subject><subject>Calmodulin - metabolism</subject><subject>mastoparan</subject><subject>Myosin-Light-Chain Kinase</subject><subject>Oligopeptides - metabolism</subject><subject>Peptides</subject><subject>Protein Binding</subject><subject>Protein Kinases - metabolism</subject><subject>Rabbits</subject><subject>Structure-Activity Relationship</subject><subject>Swine</subject><subject>Troponin - metabolism</subject><subject>Troponin I</subject><subject>Turkeys</subject><subject>Wasp Venoms - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLAzEQhYMotVb_gcI-iT6sJtlsmrwIUrxBwRcF30Iukzayl5rsCv33bm3po8LAwJwzZ4YPoXOCbwgm_BZjzHMqyceVKK4lKSXN5QEaEyxxTglmh2i8txyjk5Q-MSaEcTlCI86FKJgYI_4cFstMex-a0K0zExoXmkXW-qxbQlbr1LUrHXWTMrPOrK7q1vVVaE7RkddVgrNdn6D3x4e32XM-f316md3Pc8tK1uVeYmY4M4QR7IfyYqpLLt3wnTPcuukwM4WYUss9BeopdkDBgIaCyHJ4cYIut7mr2H71kDpVh2ShqnQDbZ-UwByzUsp_jaTgjNCyGIxsa7SxTSmCV6sYah3XimC14ao20NQGmhKF-uWqNvkXu_ze1OD2SzuQg3631WGg8R0gqmQDNBZciGA75drw94Eff5KGaA</recordid><startdate>19830718</startdate><enddate>19830718</enddate><creator>Malencik, Dean A.</creator><creator>Anderson, Sonia R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19830718</creationdate><title>High affinity binding of the mastoparans by calmodulin</title><author>Malencik, Dean A. ; Anderson, Sonia R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-f904b64b1410f10ff87a569d104db6cd710fb3872c6f2e2f20de2ebeae3195883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Bee Venoms - metabolism</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>calmodulin</topic><topic>Calmodulin - metabolism</topic><topic>mastoparan</topic><topic>Myosin-Light-Chain Kinase</topic><topic>Oligopeptides - metabolism</topic><topic>Peptides</topic><topic>Protein Binding</topic><topic>Protein Kinases - metabolism</topic><topic>Rabbits</topic><topic>Structure-Activity Relationship</topic><topic>Swine</topic><topic>Troponin - metabolism</topic><topic>Troponin I</topic><topic>Turkeys</topic><topic>Wasp Venoms - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malencik, Dean A.</creatorcontrib><creatorcontrib>Anderson, Sonia R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malencik, Dean A.</au><au>Anderson, Sonia R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High affinity binding of the mastoparans by calmodulin</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1983-07-18</date><risdate>1983</risdate><volume>114</volume><issue>1</issue><spage>50</spage><epage>56</epage><pages>50-56</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Calmodulin exhibits high affinity, calcium-dependent binding of the mastoparans — a group of cytoactive tetradecapeptides. The dissociation constants for the peptide-calmodulin complexes determined in 0.20 N KCl, 1.0 mM CaCl
2, pH 7.3 are ∼0.3 nM for mastoparan, ∼0.9 nM for mastoparan X, and ∼3.5 nM for
Polistes
mastoparan. The dissociation constant for the mastoparan-calmodulin complex is the smallest known for any calmodulin binding protein or peptide, suggesting that some type of peptide-calmodulin interaction could be physiologically significant.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6688348</pmid><doi>10.1016/0006-291X(83)91592-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1983-07, Vol.114 (1), p.50-56 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80604599 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bee Venoms - metabolism Calcium-Binding Proteins - metabolism calmodulin Calmodulin - metabolism mastoparan Myosin-Light-Chain Kinase Oligopeptides - metabolism Peptides Protein Binding Protein Kinases - metabolism Rabbits Structure-Activity Relationship Swine Troponin - metabolism Troponin I Turkeys Wasp Venoms - metabolism |
| title | High affinity binding of the mastoparans by calmodulin |
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