Renin Promoter SV40 T-Antigen Transgenic Mouse A Model of Primary Renal Vascular Hyperplasia

Transgenic mice containing a ren-2 promoter T-antigen fusion construct (TAG+) develop renal vascular hypertrophy and hyperplasia associated with markedly suppressed renal renin mRNA, renal renin content, and plasma renin concentration. These animals are normotensive. In the present study, the renal...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-06, Vol.17 (6, Part 2), p.1167-1172
Hauptverfasser:	Jacob, Howard J, Sigmund, Curt D, Shockley, Ty R, Gross, Kenneth W, Dzau, Victor J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Polyomavirus Transforming - genetics Blood Pressure Blood Vessels - pathology Blood Volume Hematocrit Hyperplasia Kidney - physiology Mice Mice, Transgenic - genetics Promoter Regions, Genetic Renal Circulation Renin - blood Renin - genetics
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