Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment
A morphometric study of the synapses on dendritic shafts and spines was performed in the rat caudate nucleus and the CAI area of the hippocampus under chronic haloperidol treatment. In the nucleus caudatus, the synaptic density of dendritic shafts increased by 83% and those on spines by 53%. Most of...
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| Veröffentlicht in: | Synapse (New York, N.Y.) N.Y.), 1991-04, Vol.7 (4), p.253-259 |
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| container_title | Synapse (New York, N.Y.) |
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| creator | Uranova, Natalya A. Orlovskaya, Diana D. Apel, Katrin Klintsova, Anna J. Haselhorst, Uwe Schenk, Herwart |
| description | A morphometric study of the synapses on dendritic shafts and spines was performed in the rat caudate nucleus and the CAI area of the hippocampus under chronic haloperidol treatment. In the nucleus caudatus, the synaptic density of dendritic shafts increased by 83% and those on spines by 53%. Most of the parameters measured in axospinous synapses were significantly increased: the area of presynptic axon terminals (20%), the number of mitochondria per axon terminal (51%), the length of active zone (11%), the area of postsynaptic density (23%), and the perimeter of postsynaptic density (12.5%). The area of postsynaptic spines showed no changes. In the synapses on dendritic shafts, the area of presynaptic terminals decreased (31%), the area of mitochondria per terminal decreased (40%), the lingth of active zone increased (14%), and other parameters were unchanged. There were no significant differences in the same parameters measured in the hippocampus. The data are discussed as morphological correlates of behavioral supersensitivity and dopamine D2 receptor up‐regulation. |
| doi_str_mv | 10.1002/syn.890070402 |
| format | Article |
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In the nucleus caudatus, the synaptic density of dendritic shafts increased by 83% and those on spines by 53%. Most of the parameters measured in axospinous synapses were significantly increased: the area of presynptic axon terminals (20%), the number of mitochondria per axon terminal (51%), the length of active zone (11%), the area of postsynaptic density (23%), and the perimeter of postsynaptic density (12.5%). The area of postsynaptic spines showed no changes. In the synapses on dendritic shafts, the area of presynaptic terminals decreased (31%), the area of mitochondria per terminal decreased (40%), the lingth of active zone increased (14%), and other parameters were unchanged. There were no significant differences in the same parameters measured in the hippocampus. The data are discussed as morphological correlates of behavioral supersensitivity and dopamine D2 receptor up‐regulation.</description><identifier>ISSN: 0887-4476</identifier><identifier>EISSN: 1098-2396</identifier><identifier>DOI: 10.1002/syn.890070402</identifier><identifier>PMID: 2042108</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Axons - drug effects ; Axons - ultrastructure ; Caudate nucleus ; Caudate Nucleus - drug effects ; Caudate Nucleus - ultrastructure ; Dendrites - drug effects ; Dendrites - ultrastructure ; Electron microscopy ; Haloperidol ; Haloperidol - pharmacology ; Hippocampus - drug effects ; Hippocampus - ultrastructure ; Male ; Microscopy, Electron ; Mitochondria - drug effects ; Mitochondria - ultrastructure ; Morphometry ; Pyramidal Tracts - drug effects ; Pyramidal Tracts - ultrastructure ; Rats ; Rats, Inbred Strains ; Reference Values ; Synapses ; Synapses - drug effects ; Synapses - ultrastructure</subject><ispartof>Synapse (New York, N.Y.), 1991-04, Vol.7 (4), p.253-259</ispartof><rights>Copyright © 1991 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-2dec8f0091fc423f612fa1bdbf6ceab404f2f08bf1f5b304e8c2a8201365612a3</citedby><cites>FETCH-LOGICAL-c4052-2dec8f0091fc423f612fa1bdbf6ceab404f2f08bf1f5b304e8c2a8201365612a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsyn.890070402$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsyn.890070402$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2042108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uranova, Natalya A.</creatorcontrib><creatorcontrib>Orlovskaya, Diana D.</creatorcontrib><creatorcontrib>Apel, Katrin</creatorcontrib><creatorcontrib>Klintsova, Anna J.</creatorcontrib><creatorcontrib>Haselhorst, Uwe</creatorcontrib><creatorcontrib>Schenk, Herwart</creatorcontrib><title>Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment</title><title>Synapse (New York, N.Y.)</title><addtitle>Synapse</addtitle><description>A morphometric study of the synapses on dendritic shafts and spines was performed in the rat caudate nucleus and the CAI area of the hippocampus under chronic haloperidol treatment. In the nucleus caudatus, the synaptic density of dendritic shafts increased by 83% and those on spines by 53%. Most of the parameters measured in axospinous synapses were significantly increased: the area of presynptic axon terminals (20%), the number of mitochondria per axon terminal (51%), the length of active zone (11%), the area of postsynaptic density (23%), and the perimeter of postsynaptic density (12.5%). The area of postsynaptic spines showed no changes. In the synapses on dendritic shafts, the area of presynaptic terminals decreased (31%), the area of mitochondria per terminal decreased (40%), the lingth of active zone increased (14%), and other parameters were unchanged. There were no significant differences in the same parameters measured in the hippocampus. The data are discussed as morphological correlates of behavioral supersensitivity and dopamine D2 receptor up‐regulation.</description><subject>Animals</subject><subject>Axons - drug effects</subject><subject>Axons - ultrastructure</subject><subject>Caudate nucleus</subject><subject>Caudate Nucleus - drug effects</subject><subject>Caudate Nucleus - ultrastructure</subject><subject>Dendrites - drug effects</subject><subject>Dendrites - ultrastructure</subject><subject>Electron microscopy</subject><subject>Haloperidol</subject><subject>Haloperidol - pharmacology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - ultrastructure</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - ultrastructure</subject><subject>Morphometry</subject><subject>Pyramidal Tracts - drug effects</subject><subject>Pyramidal Tracts - ultrastructure</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><subject>Synapses</subject><subject>Synapses - drug effects</subject><subject>Synapses - ultrastructure</subject><issn>0887-4476</issn><issn>1098-2396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P1DAMQCMEWmYXjhyRcuLWxflomjmiil3QLgsIEOIUpamjKbRJSVLB_Hu6mtGIE5ws289Plk3IMwaXDIC_zPtwqbcADUjgD8iGwVZXXGzVQ7IBrZtKykY9Juc5fwcAwUCekTMOkjPQGxLexTTv4oQlDY7msvR7Gj1dpXYua2W2pWAKmQ6Blh3SZAt1dultQRoWN-KSqQ093Q3zHJ2d5jVfQo-J7uwYZ0xDH0daEtoyYShPyCNvx4xPj_GCfLl6_bl9U92-v37bvrqtnISaV7xHpz3AlnknufCKcW9Z13deObSdBOm5B9155utOgETtuNUcmFD1ylpxQV4cvHOKPxfMxUxDdjiONmBcstGgQAgJ_wVZrXWtmnuwOoAuxZwTejOnYbJpbxiY-0eY9Wbm9IiVf34UL92E_Yk-Xn7tN4f-r2HE_b9l5tO3u7_Nx02GXPD3adKmH0Y1oqnN17trw68-3LStas1H8QdmjKWz</recordid><startdate>199104</startdate><enddate>199104</enddate><creator>Uranova, Natalya A.</creator><creator>Orlovskaya, Diana D.</creator><creator>Apel, Katrin</creator><creator>Klintsova, Anna J.</creator><creator>Haselhorst, Uwe</creator><creator>Schenk, Herwart</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199104</creationdate><title>Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment</title><author>Uranova, Natalya A. ; Orlovskaya, Diana D. ; Apel, Katrin ; Klintsova, Anna J. ; Haselhorst, Uwe ; Schenk, Herwart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-2dec8f0091fc423f612fa1bdbf6ceab404f2f08bf1f5b304e8c2a8201365612a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Axons - drug effects</topic><topic>Axons - ultrastructure</topic><topic>Caudate nucleus</topic><topic>Caudate Nucleus - drug effects</topic><topic>Caudate Nucleus - ultrastructure</topic><topic>Dendrites - drug effects</topic><topic>Dendrites - ultrastructure</topic><topic>Electron microscopy</topic><topic>Haloperidol</topic><topic>Haloperidol - pharmacology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - ultrastructure</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - ultrastructure</topic><topic>Morphometry</topic><topic>Pyramidal Tracts - drug effects</topic><topic>Pyramidal Tracts - ultrastructure</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>Synapses</topic><topic>Synapses - drug effects</topic><topic>Synapses - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uranova, Natalya A.</creatorcontrib><creatorcontrib>Orlovskaya, Diana D.</creatorcontrib><creatorcontrib>Apel, Katrin</creatorcontrib><creatorcontrib>Klintsova, Anna J.</creatorcontrib><creatorcontrib>Haselhorst, Uwe</creatorcontrib><creatorcontrib>Schenk, Herwart</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Synapse (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uranova, Natalya A.</au><au>Orlovskaya, Diana D.</au><au>Apel, Katrin</au><au>Klintsova, Anna J.</au><au>Haselhorst, Uwe</au><au>Schenk, Herwart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment</atitle><jtitle>Synapse (New York, N.Y.)</jtitle><addtitle>Synapse</addtitle><date>1991-04</date><risdate>1991</risdate><volume>7</volume><issue>4</issue><spage>253</spage><epage>259</epage><pages>253-259</pages><issn>0887-4476</issn><eissn>1098-2396</eissn><abstract>A morphometric study of the synapses on dendritic shafts and spines was performed in the rat caudate nucleus and the CAI area of the hippocampus under chronic haloperidol treatment. In the nucleus caudatus, the synaptic density of dendritic shafts increased by 83% and those on spines by 53%. Most of the parameters measured in axospinous synapses were significantly increased: the area of presynptic axon terminals (20%), the number of mitochondria per axon terminal (51%), the length of active zone (11%), the area of postsynaptic density (23%), and the perimeter of postsynaptic density (12.5%). The area of postsynaptic spines showed no changes. In the synapses on dendritic shafts, the area of presynaptic terminals decreased (31%), the area of mitochondria per terminal decreased (40%), the lingth of active zone increased (14%), and other parameters were unchanged. There were no significant differences in the same parameters measured in the hippocampus. 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| ispartof | Synapse (New York, N.Y.), 1991-04, Vol.7 (4), p.253-259 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Axons - drug effects Axons - ultrastructure Caudate nucleus Caudate Nucleus - drug effects Caudate Nucleus - ultrastructure Dendrites - drug effects Dendrites - ultrastructure Electron microscopy Haloperidol Haloperidol - pharmacology Hippocampus - drug effects Hippocampus - ultrastructure Male Microscopy, Electron Mitochondria - drug effects Mitochondria - ultrastructure Morphometry Pyramidal Tracts - drug effects Pyramidal Tracts - ultrastructure Rats Rats, Inbred Strains Reference Values Synapses Synapses - drug effects Synapses - ultrastructure |
| title | Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment |
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