A Serological Test for Leprosy with a Glycolipid Specific for Mycobacterium leprae

A Serological Test for Leprosy with a Glycolipid Specific for Mycobacterium leprae

A phenolic glycolipid from Mycobacterium leprae was purified and used as antigen in an enzyme-linked immunosorbent assay. Antibodies directed against the lipid were seen in serums from leprosy patients but not in serums from uninfected controls or patients infected with other mycobacteria, including...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1983-09, Vol.221 (4615), p.1057-1059
Hauptverfasser: Young, Douglas B., Buchanan, Thomas M.
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antigens
Bacterial diseases
Bacteriological methods and techniques used in bacteriology
Bacteriology
Biological and medical sciences
Coatings
Diagnosis
Enzyme linked immunosorbent assay
Fundamental and applied biological sciences. Psychology
Glycolipids
Glycolipids - immunology
Human bacterial diseases
Humans
Immunodiagnosis
Immunologic research
Immunological research
Infections
Infectious diseases
Leprosy
Leprosy - diagnosis
Lipids
Medical sciences
Microbiology
Mycobacterium leprae
Mycobacterium leprae - immunology
Mycobacterium tuberculosis
Observations
Serodiagnosis
Serologic Tests
Tropical bacterial diseases
Tropical medicine
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Beschreibung
Zusammenfassung:A phenolic glycolipid from Mycobacterium leprae was purified and used as antigen in an enzyme-linked immunosorbent assay. Antibodies directed against the lipid were seen in serums from leprosy patients but not in serums from uninfected controls or patients infected with other mycobacteria, including Mycobacterium tuberculosis. The antibody response distinguished between the Mycobacterium leprae lipid and the structurally related phenolic glycolipid from Mycobacterium kansasii. This assay has considerable potential as a specific serodiagnostic test for leprosy infection.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6348948