Altered expression of P‐glycoprotein and cellular adhesion molecules on human multi‐drug‐resistant tumor cells does not affect their susceptibility to NK‐ and LAK‐mediated cytotoxicity

Drug resistance has been associated with resistance to NK‐ and LAK‐cell‐mediated cytotoxicity. We evaluated this issue in human cell lines, using multiple myeloma cells (8226) and 2 multi‐drug‐resistant (MDR) sublines selected using doxorubicin (8226/Dox40) and mitoxantrone (8226/MR40). In parallel,...

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Veröffentlicht in:	International journal of cancer 1991-06, Vol.48 (4), p.562-567
Hauptverfasser:	Scheper, Rik J., Dalton, William S., Grogan, Thomas M., Schlosser, Arno, Bellamy, William T., Taylor, Charles W., Scuderi, Phil, Spier, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Antigens, Differentiation, T-Lymphocyte - analysis Antigens, Surface - analysis ATP Binding Cassette Transporter, Subfamily B, Member 1 Biological and medical sciences Breast Neoplasms CD56 Antigen CD58 Antigens Cell Adhesion Cell Adhesion Molecules - analysis Cell Line Cytotoxicity, Immunologic Doxorubicin - pharmacology Drug Resistance Histocompatibility Antigens Class I - analysis Histocompatibility Antigens Class II - analysis Host-tumor relations. Immunology. Biological markers Humans Immunohistochemistry Intercellular Adhesion Molecule-1 killer cells Killer Cells, Lymphokine-Activated - immunology Killer Cells, Natural - immunology Kinetics Medical sciences Membrane Glycoproteins - analysis Membrane Glycoproteins - genetics Mitoxantrone - pharmacology Multiple Myeloma P-glycoprotein Tumors
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