The influence of avidity on signaling murine B lymphocytes with monoclonal anti-IgM antibodies. Effects of B cell proliferation versus growth inhibition (tolerance) of an immature B cell lymphoma

We have investigated the effect of the avidity of a monoclonal anti-mouse IgM antibody (mAb) on its ability to activate normal B cells vs its capacity to inhibit the growth of an immature B lymphoma, BKS-2. A panel of seven mAb with specificities for four different domains of mu-heavy chain were sel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 1991-06, Vol.146 (12), p.4120-4129
Hauptverfasser:	Udhayakumar, V, Kumar, L, Subbarao, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Anti-Idiotypic - immunology Antibodies, Monoclonal - immunology B-Lymphocytes - immunology B-Lymphocytes - physiology Biological and medical sciences Down-Regulation Fundamental and applied biological sciences. Psychology Fundamental immunology Immune Tolerance Immunobiology Immunoglobulin Fab Fragments - physiology Immunoglobulin M - analysis Immunoglobulin M - immunology Interleukin-5 - pharmacology Lipopolysaccharides - pharmacology Lymphocyte Activation Lymphoma, B-Cell - immunology Lymphoma, B-Cell - pathology Mice Mice, Inbred CBA Modulation of the immune response (stimulation, suppression) Receptors, Fc - physiology Recombinant Proteins - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!