Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain typ...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 1983-09, Vol.309 (10), p.590-594 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 594 |
|---|---|
| container_issue | 10 |
| container_start_page | 590 |
| container_title | The New England journal of medicine |
| container_volume | 309 |
| creator | Sonnier, Joseph A Buchanan, George R Howard-Peebles, Patricia N Rutledge, Joe Smith, R. Graham |
| description | Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type. Karyotyping of the abnormal cells revealed an unusual translocation [t(2;14) (p13;q32)], with break points at or near the kappa-light-chain and heavy-chain gene loci. Translocations involving the immunoglobulin gene loci may be important in the pathogenesis of some cases of chronic lymphocytic leukemia, as they appear to be in Burkitt's lymphoma. (N Engl J Med 1983; 309:590–4.)
CHRONIC lymphocytic leukemia is usually a monoclonal B-cell neoplasm
1
,
2
of middle-aged and elderly adults. Although rare cases have been reported in children,
3
4
5
none has been studied with modern immunologic and cytogenetic techniques. We have recently diagnosed chronic lymphocytic leukemia in a 10-year-old girl, whose leukemic cells expressed IgM and IgD kappa membrane immunoglobulins. Cytogenetic analysis showed a balanced 2p/14q translocation — an unexpected abnormality in this disease.
6
The exchange of genetic material between the short arm of chromosome 2 and the long arm of chromosome 14 occurred at bands p13 and q32, respectively. This finding is of great interest, since . . . |
| doi_str_mv | 10.1056/NEJM198309083091005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80591387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80591387</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-5244964af027c07418fb61e18141a6a7647dfc1c3fafdc175c8afdd5a68ad15a3</originalsourceid><addsrcrecordid>eNp9UU2P0zAQtRBoKQu_ACFZQuKCAp74I84RRQtbKHBZztHUcTYusR3ipKh3fjiJWnFAiDl4nj3vvbH0CHkO7A0wqd5-ufn4GUrNWcnWAxiTD8gGJOeZEEw9JBvGcp2JouSPyZOUDmwpEOUVuVICWM7VhvyqujH6mKLHnt6NGFIfDU4uBroNx9gfXbinU2fp1vs5xPs-7ufeBfoJhwGzqsMFY2jorcXj6XLfRePo-k6rzvUN_emmjq57gjN0d_JDF81pWrGdv1vv8Cl51GKf7LNLvybf3t_cVbfZ7uuHbfVulxnB8imTuRClEtiyvDCsEKDbvQILGgSgwkKJomkNGN5i2xgopNELaCQqjQ1I5Nfk1dl3GOOP2aap9i4Z2_cYbJxTrZksgetiIb78i3iI8xiWv9WgCym4Bp0vLH5mmTGmNNq2HkbncTzVwOo1ofofCS2qFxfvee9t80dziWSZvz7PvU91sAf_X7ffUpqYww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1875438182</pqid></control><display><type>article</type><title>Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia</title><source>MEDLINE</source><source>ProQuest Central UK/Ireland</source><creator>Sonnier, Joseph A ; Buchanan, George R ; Howard-Peebles, Patricia N ; Rutledge, Joe ; Smith, R. Graham</creator><creatorcontrib>Sonnier, Joseph A ; Buchanan, George R ; Howard-Peebles, Patricia N ; Rutledge, Joe ; Smith, R. Graham</creatorcontrib><description>Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type. Karyotyping of the abnormal cells revealed an unusual translocation [t(2;14) (p13;q32)], with break points at or near the kappa-light-chain and heavy-chain gene loci. Translocations involving the immunoglobulin gene loci may be important in the pathogenesis of some cases of chronic lymphocytic leukemia, as they appear to be in Burkitt's lymphoma. (N Engl J Med 1983; 309:590–4.)
CHRONIC lymphocytic leukemia is usually a monoclonal B-cell neoplasm
1
,
2
of middle-aged and elderly adults. Although rare cases have been reported in children,
3
4
5
none has been studied with modern immunologic and cytogenetic techniques. We have recently diagnosed chronic lymphocytic leukemia in a 10-year-old girl, whose leukemic cells expressed IgM and IgD kappa membrane immunoglobulins. Cytogenetic analysis showed a balanced 2p/14q translocation — an unexpected abnormality in this disease.
6
The exchange of genetic material between the short arm of chromosome 2 and the long arm of chromosome 14 occurred at bands p13 and q32, respectively. This finding is of great interest, since . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198309083091005</identifier><identifier>PMID: 6410236</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Abdomen ; Blood platelets ; Bone marrow ; Burkitt's lymphoma ; Child ; Chromosome Mapping ; Chromosome translocations ; Chromosomes ; Chronic lymphocytic leukemia ; Cytoplasm ; Female ; Genes ; Geriatrics ; Heavy Chain Disease - history ; History of medicine ; Humans ; Immunoglobulin D ; Immunoglobulin D - analysis ; Immunoglobulin D - genetics ; Immunoglobulin kappa-Chains - analysis ; Immunoglobulin kappa-Chains - genetics ; Immunoglobulin Light Chains - genetics ; Immunoglobulin M ; Immunoglobulin M - analysis ; Immunoglobulin M - genetics ; Immunoglobulins ; Karyotyping ; Leukemia ; Leukemia, Lymphoid - genetics ; Leukemia, Lymphoid - immunology ; Light ; Lymphatic leukemia ; Lymphatic system ; Lymphocytes ; Lymphocytes B ; Lymphoma ; Pediatrics ; Translocation, Genetic</subject><ispartof>The New England journal of medicine, 1983-09, Vol.309 (10), p.590-594</ispartof><rights>Copyright Massachusetts Medical Society Sep 8, 1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-5244964af027c07418fb61e18141a6a7647dfc1c3fafdc175c8afdd5a68ad15a3</citedby><cites>FETCH-LOGICAL-c402t-5244964af027c07418fb61e18141a6a7647dfc1c3fafdc175c8afdd5a68ad15a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1875438182?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6410236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonnier, Joseph A</creatorcontrib><creatorcontrib>Buchanan, George R</creatorcontrib><creatorcontrib>Howard-Peebles, Patricia N</creatorcontrib><creatorcontrib>Rutledge, Joe</creatorcontrib><creatorcontrib>Smith, R. Graham</creatorcontrib><title>Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type. Karyotyping of the abnormal cells revealed an unusual translocation [t(2;14) (p13;q32)], with break points at or near the kappa-light-chain and heavy-chain gene loci. Translocations involving the immunoglobulin gene loci may be important in the pathogenesis of some cases of chronic lymphocytic leukemia, as they appear to be in Burkitt's lymphoma. (N Engl J Med 1983; 309:590–4.)
CHRONIC lymphocytic leukemia is usually a monoclonal B-cell neoplasm
1
,
2
of middle-aged and elderly adults. Although rare cases have been reported in children,
3
4
5
none has been studied with modern immunologic and cytogenetic techniques. We have recently diagnosed chronic lymphocytic leukemia in a 10-year-old girl, whose leukemic cells expressed IgM and IgD kappa membrane immunoglobulins. Cytogenetic analysis showed a balanced 2p/14q translocation — an unexpected abnormality in this disease.
6
The exchange of genetic material between the short arm of chromosome 2 and the long arm of chromosome 14 occurred at bands p13 and q32, respectively. This finding is of great interest, since . . .</description><subject>Abdomen</subject><subject>Blood platelets</subject><subject>Bone marrow</subject><subject>Burkitt's lymphoma</subject><subject>Child</subject><subject>Chromosome Mapping</subject><subject>Chromosome translocations</subject><subject>Chromosomes</subject><subject>Chronic lymphocytic leukemia</subject><subject>Cytoplasm</subject><subject>Female</subject><subject>Genes</subject><subject>Geriatrics</subject><subject>Heavy Chain Disease - history</subject><subject>History of medicine</subject><subject>Humans</subject><subject>Immunoglobulin D</subject><subject>Immunoglobulin D - analysis</subject><subject>Immunoglobulin D - genetics</subject><subject>Immunoglobulin kappa-Chains - analysis</subject><subject>Immunoglobulin kappa-Chains - genetics</subject><subject>Immunoglobulin Light Chains - genetics</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - analysis</subject><subject>Immunoglobulin M - genetics</subject><subject>Immunoglobulins</subject><subject>Karyotyping</subject><subject>Leukemia</subject><subject>Leukemia, Lymphoid - genetics</subject><subject>Leukemia, Lymphoid - immunology</subject><subject>Light</subject><subject>Lymphatic leukemia</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphoma</subject><subject>Pediatrics</subject><subject>Translocation, Genetic</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UU2P0zAQtRBoKQu_ACFZQuKCAp74I84RRQtbKHBZztHUcTYusR3ipKh3fjiJWnFAiDl4nj3vvbH0CHkO7A0wqd5-ufn4GUrNWcnWAxiTD8gGJOeZEEw9JBvGcp2JouSPyZOUDmwpEOUVuVICWM7VhvyqujH6mKLHnt6NGFIfDU4uBroNx9gfXbinU2fp1vs5xPs-7ufeBfoJhwGzqsMFY2jorcXj6XLfRePo-k6rzvUN_emmjq57gjN0d_JDF81pWrGdv1vv8Cl51GKf7LNLvybf3t_cVbfZ7uuHbfVulxnB8imTuRClEtiyvDCsEKDbvQILGgSgwkKJomkNGN5i2xgopNELaCQqjQ1I5Nfk1dl3GOOP2aap9i4Z2_cYbJxTrZksgetiIb78i3iI8xiWv9WgCym4Bp0vLH5mmTGmNNq2HkbncTzVwOo1ofofCS2qFxfvee9t80dziWSZvz7PvU91sAf_X7ffUpqYww</recordid><startdate>19830908</startdate><enddate>19830908</enddate><creator>Sonnier, Joseph A</creator><creator>Buchanan, George R</creator><creator>Howard-Peebles, Patricia N</creator><creator>Rutledge, Joe</creator><creator>Smith, R. Graham</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19830908</creationdate><title>Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia</title><author>Sonnier, Joseph A ; Buchanan, George R ; Howard-Peebles, Patricia N ; Rutledge, Joe ; Smith, R. Graham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-5244964af027c07418fb61e18141a6a7647dfc1c3fafdc175c8afdd5a68ad15a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Abdomen</topic><topic>Blood platelets</topic><topic>Bone marrow</topic><topic>Burkitt's lymphoma</topic><topic>Child</topic><topic>Chromosome Mapping</topic><topic>Chromosome translocations</topic><topic>Chromosomes</topic><topic>Chronic lymphocytic leukemia</topic><topic>Cytoplasm</topic><topic>Female</topic><topic>Genes</topic><topic>Geriatrics</topic><topic>Heavy Chain Disease - history</topic><topic>History of medicine</topic><topic>Humans</topic><topic>Immunoglobulin D</topic><topic>Immunoglobulin D - analysis</topic><topic>Immunoglobulin D - genetics</topic><topic>Immunoglobulin kappa-Chains - analysis</topic><topic>Immunoglobulin kappa-Chains - genetics</topic><topic>Immunoglobulin Light Chains - genetics</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - analysis</topic><topic>Immunoglobulin M - genetics</topic><topic>Immunoglobulins</topic><topic>Karyotyping</topic><topic>Leukemia</topic><topic>Leukemia, Lymphoid - genetics</topic><topic>Leukemia, Lymphoid - immunology</topic><topic>Light</topic><topic>Lymphatic leukemia</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphoma</topic><topic>Pediatrics</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonnier, Joseph A</creatorcontrib><creatorcontrib>Buchanan, George R</creatorcontrib><creatorcontrib>Howard-Peebles, Patricia N</creatorcontrib><creatorcontrib>Rutledge, Joe</creatorcontrib><creatorcontrib>Smith, R. Graham</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Health & Medical Collection (ProQuest Medical & Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (ProQuest Medical & Health Databases)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>New England Journal of Medicine</collection><collection>Biological Sciences</collection><collection>ProQuest Consumer Health Database</collection><collection>ProQuest Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Psychology Database</collection><collection>ProQuest Research Library</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonnier, Joseph A</au><au>Buchanan, George R</au><au>Howard-Peebles, Patricia N</au><au>Rutledge, Joe</au><au>Smith, R. Graham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1983-09-08</date><risdate>1983</risdate><volume>309</volume><issue>10</issue><spage>590</spage><epage>594</epage><pages>590-594</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Chronic lymphocytic leukemia is usually a monoclonal B-cell neoplasm that occurs almost exclusively in middle-aged and elderly adults. We observed a rapidly progressive case of the disease in a 10-year-old girl. The leukemic cells bore surface IgM and IgD immunoglobulins of the kappa-light-chain type. Karyotyping of the abnormal cells revealed an unusual translocation [t(2;14) (p13;q32)], with break points at or near the kappa-light-chain and heavy-chain gene loci. Translocations involving the immunoglobulin gene loci may be important in the pathogenesis of some cases of chronic lymphocytic leukemia, as they appear to be in Burkitt's lymphoma. (N Engl J Med 1983; 309:590–4.)
CHRONIC lymphocytic leukemia is usually a monoclonal B-cell neoplasm
1
,
2
of middle-aged and elderly adults. Although rare cases have been reported in children,
3
4
5
none has been studied with modern immunologic and cytogenetic techniques. We have recently diagnosed chronic lymphocytic leukemia in a 10-year-old girl, whose leukemic cells expressed IgM and IgD kappa membrane immunoglobulins. Cytogenetic analysis showed a balanced 2p/14q translocation — an unexpected abnormality in this disease.
6
The exchange of genetic material between the short arm of chromosome 2 and the long arm of chromosome 14 occurred at bands p13 and q32, respectively. This finding is of great interest, since . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>6410236</pmid><doi>10.1056/NEJM198309083091005</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1983-09, Vol.309 (10), p.590-594 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80591387 |
| source | MEDLINE; ProQuest Central UK/Ireland |
| subjects | Abdomen Blood platelets Bone marrow Burkitt's lymphoma Child Chromosome Mapping Chromosome translocations Chromosomes Chronic lymphocytic leukemia Cytoplasm Female Genes Geriatrics Heavy Chain Disease - history History of medicine Humans Immunoglobulin D Immunoglobulin D - analysis Immunoglobulin D - genetics Immunoglobulin kappa-Chains - analysis Immunoglobulin kappa-Chains - genetics Immunoglobulin Light Chains - genetics Immunoglobulin M Immunoglobulin M - analysis Immunoglobulin M - genetics Immunoglobulins Karyotyping Leukemia Leukemia, Lymphoid - genetics Leukemia, Lymphoid - immunology Light Lymphatic leukemia Lymphatic system Lymphocytes Lymphocytes B Lymphoma Pediatrics Translocation, Genetic |
| title | Chromosomal Translocation Involving the Immunoglobulin Kappa-Chain and Heavy-Chain Loci in a Child with Chronic Lymphocytic Leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A10%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chromosomal%20Translocation%20Involving%20the%20Immunoglobulin%20Kappa-Chain%20and%20Heavy-Chain%20Loci%20in%20a%20Child%20with%20Chronic%20Lymphocytic%20Leukemia&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Sonnier,%20Joseph%20A&rft.date=1983-09-08&rft.volume=309&rft.issue=10&rft.spage=590&rft.epage=594&rft.pages=590-594&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJM198309083091005&rft_dat=%3Cproquest_cross%3E80591387%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1875438182&rft_id=info:pmid/6410236&rfr_iscdi=true |