Concentration of Salmonella pullorum antigen and the immunosuppressive effect of adrenocorticotropin in growing chickens
The role of antigen concentration on the immunosuppressive effect of adrenocorticotropin (ACTH) was tested in 6-week-old White Rock chickens that were immunized i.v. with 1 ml of heat-treated Salmonella pullorum at packed cell volume concentrations of .06 to .00015%, At 16 and 10 hr before the antig...
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| Veröffentlicht in: | Poultry science 1983-05, Vol.62 (5), p.897-903 |
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| creator | Siegel, H S Latimer, J W Gould, N R |
| description | The role of antigen concentration on the immunosuppressive effect of adrenocorticotropin (ACTH) was tested in 6-week-old White Rock chickens that were immunized i.v. with 1 ml of heat-treated Salmonella pullorum at packed cell volume concentrations of .06 to .00015%, At 16 and 10 hr before the antigen (Ag) injection, the birds received either 4 IU . 100 g body wt-1 of ACTH i.m., or the gelatin (Gel) vehicle. Total, 2-mercaptoethanol sensitive (2-MES), and 2-mercaptoethanol resistant (2-MER) agglutinin antibody titers were determined. The ACTH significantly suppressed total agglutinin titers with the lower Ag concentrations (.0015 and .00015%) but not with the higher Ag concentrations. The ACTH significantly suppressed 2-MES titers only when Ag concentrations were low but suppressed 2-MER titers regardless of Ag concentration. The results indicated that there may be critical Ag concentrations capable of inducing maximal humoral antibody responses in moderate environments but which allow these responses to be suppressed by environments that stimulate increased pituitary-adrenal activity. |
| doi_str_mv | 10.3382/ps.0620897 |
| format | Article |
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Faculty of Veterinary Sciences</creatorcontrib><description>The role of antigen concentration on the immunosuppressive effect of adrenocorticotropin (ACTH) was tested in 6-week-old White Rock chickens that were immunized i.v. with 1 ml of heat-treated Salmonella pullorum at packed cell volume concentrations of .06 to .00015%, At 16 and 10 hr before the antigen (Ag) injection, the birds received either 4 IU . 100 g body wt-1 of ACTH i.m., or the gelatin (Gel) vehicle. Total, 2-mercaptoethanol sensitive (2-MES), and 2-mercaptoethanol resistant (2-MER) agglutinin antibody titers were determined. The ACTH significantly suppressed total agglutinin titers with the lower Ag concentrations (.0015 and .00015%) but not with the higher Ag concentrations. The ACTH significantly suppressed 2-MES titers only when Ag concentrations were low but suppressed 2-MER titers regardless of Ag concentration. The results indicated that there may be critical Ag concentrations capable of inducing maximal humoral antibody responses in moderate environments but which allow these responses to be suppressed by environments that stimulate increased pituitary-adrenal activity.</description><identifier>ISSN: 0032-5791</identifier><identifier>EISSN: 1525-3171</identifier><identifier>DOI: 10.3382/ps.0620897</identifier><identifier>PMID: 6308589</identifier><language>eng</language><publisher>England</publisher><subject>Adrenocorticotropic Hormone - pharmacology ; Agglutinins - analysis ; Animals ; Antibodies, Bacterial - biosynthesis ; Antigens, Bacterial - administration & dosage ; Chickens ; Female ; Immunization - veterinary ; Immunoglobulins - analysis ; Immunosuppressive Agents ; Male ; Mercaptoethanol - pharmacology ; Poultry Diseases - immunology ; Salmonella - immunology ; Salmonella Infections, Animal - immunology</subject><ispartof>Poultry science, 1983-05, Vol.62 (5), p.897-903</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-9aeb2acfb096c759b23932658a781b6bec006b93675b94af4f2890a8200248073</citedby><cites>FETCH-LOGICAL-c341t-9aeb2acfb096c759b23932658a781b6bec006b93675b94af4f2890a8200248073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6308589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siegel, H S</creatorcontrib><creatorcontrib>Latimer, J W</creatorcontrib><creatorcontrib>Gould, N R</creatorcontrib><creatorcontrib>University of Agriculture, Faisalabad (Pakistan). Faculty of Veterinary Sciences</creatorcontrib><title>Concentration of Salmonella pullorum antigen and the immunosuppressive effect of adrenocorticotropin in growing chickens</title><title>Poultry science</title><addtitle>Poult Sci</addtitle><description>The role of antigen concentration on the immunosuppressive effect of adrenocorticotropin (ACTH) was tested in 6-week-old White Rock chickens that were immunized i.v. with 1 ml of heat-treated Salmonella pullorum at packed cell volume concentrations of .06 to .00015%, At 16 and 10 hr before the antigen (Ag) injection, the birds received either 4 IU . 100 g body wt-1 of ACTH i.m., or the gelatin (Gel) vehicle. Total, 2-mercaptoethanol sensitive (2-MES), and 2-mercaptoethanol resistant (2-MER) agglutinin antibody titers were determined. The ACTH significantly suppressed total agglutinin titers with the lower Ag concentrations (.0015 and .00015%) but not with the higher Ag concentrations. The ACTH significantly suppressed 2-MES titers only when Ag concentrations were low but suppressed 2-MER titers regardless of Ag concentration. The results indicated that there may be critical Ag concentrations capable of inducing maximal humoral antibody responses in moderate environments but which allow these responses to be suppressed by environments that stimulate increased pituitary-adrenal activity.</description><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Agglutinins - analysis</subject><subject>Animals</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antigens, Bacterial - administration & dosage</subject><subject>Chickens</subject><subject>Female</subject><subject>Immunization - veterinary</subject><subject>Immunoglobulins - analysis</subject><subject>Immunosuppressive Agents</subject><subject>Male</subject><subject>Mercaptoethanol - pharmacology</subject><subject>Poultry Diseases - immunology</subject><subject>Salmonella - immunology</subject><subject>Salmonella Infections, Animal - immunology</subject><issn>0032-5791</issn><issn>1525-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM2LFDEUxIMo67h68a7k5EHo9SXppJOjDH7Bgod1zyGdeZmNdidtkvbjv7eHGYQHdajfK6gi5CWDGyE0f7fUG1ActBkekR2TXHaCDewx2QEI3snBsKfkWa3fAThTargiV0qAltrsyJ99Th5TK67FnGgO9M5Nc044TY4u6zTlss7UpRaPmDY90PaANM7zmnJdl6VgrfEXUgwBfTv9u0PBlH0uLfrcSl5iotsdS_4d05H6h-h_YKrPyZPgpoovLnpN7j9--Lb_3N1-_fRl__6286JnrTMOR-58GMEoP0gzcmEEV1K7QbNRjegB1GiEGuRoehf6wLUBp_nWtdcwiGvy5py7lPxzxdrsHKs_1UuY12o1SAMg5Qa-PYO-5FoLBruUOLvy1zKwp5ntUu1l5g1-dUldxxkP_9HLrpv_-uwHl607lljt_R0zugfoFdNC_APj0YOb</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>Siegel, H S</creator><creator>Latimer, J W</creator><creator>Gould, N R</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Concentration of Salmonella pullorum antigen and the immunosuppressive effect of adrenocorticotropin in growing chickens</title><author>Siegel, H S ; Latimer, J W ; Gould, N R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-9aeb2acfb096c759b23932658a781b6bec006b93675b94af4f2890a8200248073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Agglutinins - analysis</topic><topic>Animals</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antigens, Bacterial - administration & dosage</topic><topic>Chickens</topic><topic>Female</topic><topic>Immunization - veterinary</topic><topic>Immunoglobulins - analysis</topic><topic>Immunosuppressive Agents</topic><topic>Male</topic><topic>Mercaptoethanol - pharmacology</topic><topic>Poultry Diseases - immunology</topic><topic>Salmonella - immunology</topic><topic>Salmonella Infections, Animal - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siegel, H S</creatorcontrib><creatorcontrib>Latimer, J W</creatorcontrib><creatorcontrib>Gould, N R</creatorcontrib><creatorcontrib>University of Agriculture, Faisalabad (Pakistan). Faculty of Veterinary Sciences</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Poultry science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siegel, H S</au><au>Latimer, J W</au><au>Gould, N R</au><aucorp>University of Agriculture, Faisalabad (Pakistan). Faculty of Veterinary Sciences</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concentration of Salmonella pullorum antigen and the immunosuppressive effect of adrenocorticotropin in growing chickens</atitle><jtitle>Poultry science</jtitle><addtitle>Poult Sci</addtitle><date>1983-05</date><risdate>1983</risdate><volume>62</volume><issue>5</issue><spage>897</spage><epage>903</epage><pages>897-903</pages><issn>0032-5791</issn><eissn>1525-3171</eissn><abstract>The role of antigen concentration on the immunosuppressive effect of adrenocorticotropin (ACTH) was tested in 6-week-old White Rock chickens that were immunized i.v. with 1 ml of heat-treated Salmonella pullorum at packed cell volume concentrations of .06 to .00015%, At 16 and 10 hr before the antigen (Ag) injection, the birds received either 4 IU . 100 g body wt-1 of ACTH i.m., or the gelatin (Gel) vehicle. Total, 2-mercaptoethanol sensitive (2-MES), and 2-mercaptoethanol resistant (2-MER) agglutinin antibody titers were determined. The ACTH significantly suppressed total agglutinin titers with the lower Ag concentrations (.0015 and .00015%) but not with the higher Ag concentrations. The ACTH significantly suppressed 2-MES titers only when Ag concentrations were low but suppressed 2-MER titers regardless of Ag concentration. The results indicated that there may be critical Ag concentrations capable of inducing maximal humoral antibody responses in moderate environments but which allow these responses to be suppressed by environments that stimulate increased pituitary-adrenal activity.</abstract><cop>England</cop><pmid>6308589</pmid><doi>10.3382/ps.0620897</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-5791 |
| ispartof | Poultry science, 1983-05, Vol.62 (5), p.897-903 |
| issn | 0032-5791 1525-3171 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80590055 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adrenocorticotropic Hormone - pharmacology Agglutinins - analysis Animals Antibodies, Bacterial - biosynthesis Antigens, Bacterial - administration & dosage Chickens Female Immunization - veterinary Immunoglobulins - analysis Immunosuppressive Agents Male Mercaptoethanol - pharmacology Poultry Diseases - immunology Salmonella - immunology Salmonella Infections, Animal - immunology |
| title | Concentration of Salmonella pullorum antigen and the immunosuppressive effect of adrenocorticotropin in growing chickens |
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