Carcinoembryonic antigen regulation in human colorectal tumor cells by a site‐selective cyclic amp analogue: A comparison with interferon‐gamma

Treatment of human colorectal tumor cells (LS174T, HT29, and WIDr) with analogues of cyclic AMP (cAMP) (dibutyryl‐cAMP and 8‐Cl‐cAMP) selectively enhances the expression of carcinoembryonic antigen (CEA). Dose and temporal kinetics results revealed that 8‐Cl‐cAMP was approximately 100‐fold more pote...

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Veröffentlicht in:	International journal of cancer 1991-05, Vol.48 (3), p.413-422
Hauptverfasser:	Guadagni, Fiorella, Tortora, Giampaolo, Roselli, Mario, Clair, Tim, Cho‐Chung, Yoon Sang, Schlom, Jeffrey, Greiner, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - analogs & derivatives 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Animals Antibodies, Monoclonal Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Bucladesine - pharmacology Carcinoembryonic Antigen - analysis Carcinoembryonic Antigen - biosynthesis Cell Line Chemotherapy Colonic Neoplasms - immunology Colorectal Neoplasms - immunology Dose-Response Relationship, Drug Histocompatibility Antigens Class I - analysis Histocompatibility Antigens Class I - biosynthesis Humans Interferon-gamma - pharmacology Kinetics Medical sciences Mice Mice, Nude Pharmacology. Drug treatments Radioimmunoassay Recombinant Proteins Rectal Neoplasms - immunology Transplantation, Heterologous
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