Nuclear progesterone uptake by endometrial tissue in cases of subfertility
To investigate the ability of steroid hormones to interact with endometrium, particularly in cases of unexplained subfertility, intact cells were incubated with tritiated progesterone and oestradiol and their uptake into the nuclei was measured. Samples were taken at dilatation and curettage from 23...
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| Veröffentlicht in: | The Lancet (British edition) 1983-08, Vol.2 (8345), p.310-312 |
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| container_issue | 8345 |
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| container_title | The Lancet (British edition) |
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| creator | Maynard, P V Baker, P N Symonds, E M Sant-Cassia, L J Johnson, J Selby, C |
| description | To investigate the ability of steroid hormones to interact with endometrium, particularly in cases of unexplained subfertility, intact cells were incubated with tritiated progesterone and oestradiol and their uptake into the nuclei was measured. Samples were taken at dilatation and curettage from 23 fertile women, 14 women with unexplained primary subfertility, and 9 patients whose primary subfertility could be explained. Serum oestradiol and progesterone levels were not significantly different between the three groups, nor were values of 3H-oestradiol uptake. However, low (below 5 pmol/mg DNA) values for nuclear 3H-progesterone uptake were present in most samples from women with unexplained subfertility but in only about half of the women in the other two groups. This biochemical defect may be the cause of some cases of unexplained subfertility. |
| format | Article |
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Samples were taken at dilatation and curettage from 23 fertile women, 14 women with unexplained primary subfertility, and 9 patients whose primary subfertility could be explained. Serum oestradiol and progesterone levels were not significantly different between the three groups, nor were values of 3H-oestradiol uptake. However, low (below 5 pmol/mg DNA) values for nuclear 3H-progesterone uptake were present in most samples from women with unexplained subfertility but in only about half of the women in the other two groups. 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Samples were taken at dilatation and curettage from 23 fertile women, 14 women with unexplained primary subfertility, and 9 patients whose primary subfertility could be explained. Serum oestradiol and progesterone levels were not significantly different between the three groups, nor were values of 3H-oestradiol uptake. However, low (below 5 pmol/mg DNA) values for nuclear 3H-progesterone uptake were present in most samples from women with unexplained subfertility but in only about half of the women in the other two groups. 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| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1983-08, Vol.2 (8345), p.310-312 |
| issn | 0140-6736 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80587879 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Cell Nucleus - metabolism Endometrium - cytology Endometrium - metabolism Estradiol - blood Estradiol - metabolism Female Humans Infertility, Female - etiology Infertility, Female - metabolism Menstruation Progesterone - blood Progesterone - metabolism Receptors, Progesterone - metabolism Tritium |
| title | Nuclear progesterone uptake by endometrial tissue in cases of subfertility |
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