Age-related changes in rat brain capillaries
We have measured several morphological parameters by electron microscopy of frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rat 3-, 9- and 24-months old. The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membra...
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| Veröffentlicht in: | Neurobiology of aging 1983-01, Vol.4 (1), p.69-75 |
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| container_title | Neurobiology of aging |
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| creator | Hicks, P. Rolsten, C. Brizzee, D. Samorajski, T. |
| description | We have measured several morphological parameters by electron microscopy of frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rat 3-, 9- and 24-months old. The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membrane, increase in the friction of endothelial cell and pericyte cytoplasmic area occupied by mitochondria in the FC, increase in the size of the pericyte mitochondria in both the FC and HC, increased capillary lumen area in the FC and decreased capillary lumen area in the HC. Also, the cytoplasmic area occupied by mitochondria in capillary pericytes is larger than in the endothelial cells of both FC and HC. These results suggest that there is regional variation in the age-associated changes in capillary morphometrics. |
| doi_str_mv | 10.1016/0197-4580(83)90057-X |
| format | Article |
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The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membrane, increase in the friction of endothelial cell and pericyte cytoplasmic area occupied by mitochondria in the FC, increase in the size of the pericyte mitochondria in both the FC and HC, increased capillary lumen area in the FC and decreased capillary lumen area in the HC. Also, the cytoplasmic area occupied by mitochondria in capillary pericytes is larger than in the endothelial cells of both FC and HC. These results suggest that there is regional variation in the age-associated changes in capillary morphometrics.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(83)90057-X</identifier><identifier>PMID: 6877490</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; Animals ; Basement membrane ; Blood brain barrier ; Capillaries - anatomy & histology ; Capillaries - cytology ; Capillaries - ultrastructure ; Cerebral capillaries ; Cerebrovascular Circulation ; Male ; Microscopy, Electron ; Mitochondria ; Mitochondria - ultrastructure ; Pericytes ; Rats ; Rats, Inbred F344</subject><ispartof>Neurobiology of aging, 1983-01, Vol.4 (1), p.69-75</ispartof><rights>1983</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-7e930d1599daba22d533b433391883b86bbbb75e3378528be86e3f549c3daca13</citedby><cites>FETCH-LOGICAL-c439t-7e930d1599daba22d533b433391883b86bbbb75e3378528be86e3f549c3daca13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0197-4580(83)90057-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6877490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hicks, P.</creatorcontrib><creatorcontrib>Rolsten, C.</creatorcontrib><creatorcontrib>Brizzee, D.</creatorcontrib><creatorcontrib>Samorajski, T.</creatorcontrib><title>Age-related changes in rat brain capillaries</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>We have measured several morphological parameters by electron microscopy of frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rat 3-, 9- and 24-months old. 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These results suggest that there is regional variation in the age-associated changes in capillary morphometrics.</description><subject>Aging</subject><subject>Animals</subject><subject>Basement membrane</subject><subject>Blood brain barrier</subject><subject>Capillaries - anatomy & histology</subject><subject>Capillaries - cytology</subject><subject>Capillaries - ultrastructure</subject><subject>Cerebral capillaries</subject><subject>Cerebrovascular Circulation</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Mitochondria</subject><subject>Mitochondria - ultrastructure</subject><subject>Pericytes</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotX78A4U9iYKryU6ySS5CKX5BwYtCbyGbTGtku1uTreC_d2tLjzqXGXjfd2Z4CDlj9IZRVt5SpmXOhaKXCq40pULm0z0yZEKonHEt98lwZzkkRyl9UEoll-WADEolJdd0SK5Hc8wj1rZDn7l328wxZaHJou2yKtp-cnYZ6trGgOmEHMxsnfB024_J28P96_gpn7w8Po9Hk9xx0F0uUQP1TGjtbWWLwguAigOAZkpBpcqqLykQQCpRqApViTATXDvw1lkGx-Ris3cZ288Vps4sQnLYf9Fgu0pGUaFKodW_RgalYKKgvZFvjC62KUWcmWUMCxu_DaNmTdOsUZk1KqPA_NI00z52vt2_qhbod6Etvl6_2-jY0_gKGE1yARuHPkR0nfFt-PvAD3xyggs</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Hicks, P.</creator><creator>Rolsten, C.</creator><creator>Brizzee, D.</creator><creator>Samorajski, T.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Age-related changes in rat brain capillaries</title><author>Hicks, P. ; Rolsten, C. ; Brizzee, D. ; Samorajski, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-7e930d1599daba22d533b433391883b86bbbb75e3378528be86e3f549c3daca13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Basement membrane</topic><topic>Blood brain barrier</topic><topic>Capillaries - anatomy & histology</topic><topic>Capillaries - cytology</topic><topic>Capillaries - ultrastructure</topic><topic>Cerebral capillaries</topic><topic>Cerebrovascular Circulation</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Mitochondria</topic><topic>Mitochondria - ultrastructure</topic><topic>Pericytes</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hicks, P.</creatorcontrib><creatorcontrib>Rolsten, C.</creatorcontrib><creatorcontrib>Brizzee, D.</creatorcontrib><creatorcontrib>Samorajski, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hicks, P.</au><au>Rolsten, C.</au><au>Brizzee, D.</au><au>Samorajski, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in rat brain capillaries</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>4</volume><issue>1</issue><spage>69</spage><epage>75</epage><pages>69-75</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>We have measured several morphological parameters by electron microscopy of frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rat 3-, 9- and 24-months old. The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membrane, increase in the friction of endothelial cell and pericyte cytoplasmic area occupied by mitochondria in the FC, increase in the size of the pericyte mitochondria in both the FC and HC, increased capillary lumen area in the FC and decreased capillary lumen area in the HC. Also, the cytoplasmic area occupied by mitochondria in capillary pericytes is larger than in the endothelial cells of both FC and HC. These results suggest that there is regional variation in the age-associated changes in capillary morphometrics.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6877490</pmid><doi>10.1016/0197-4580(83)90057-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neurobiology of aging, 1983-01, Vol.4 (1), p.69-75 |
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| subjects | Aging Animals Basement membrane Blood brain barrier Capillaries - anatomy & histology Capillaries - cytology Capillaries - ultrastructure Cerebral capillaries Cerebrovascular Circulation Male Microscopy, Electron Mitochondria Mitochondria - ultrastructure Pericytes Rats Rats, Inbred F344 |
| title | Age-related changes in rat brain capillaries |
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