Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimet...
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| Veröffentlicht in: | Journal of clinical pharmacology 1983-05, Vol.23 (5-6), p.252-256 |
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| container_issue | 5-6 |
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| container_title | Journal of clinical pharmacology |
| container_volume | 23 |
| creator | KOGAN, FREDERICK J. SAMPLINER, RICHARD E. MAYERSOHN, MICHAEL KAZAMA, RODNEY M. PERRIER, DONALD JONES, WILLIAM MICHAEL, ULRICH F. |
| description | : Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis. |
| doi_str_mv | 10.1002/j.1552-4604.1983.tb02732.x |
| format | Article |
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Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1983.tb02732.x</identifier><identifier>PMID: 6875024</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Cimetidine - blood ; Cimetidine - metabolism ; Guanidines - metabolism ; Half-Life ; Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; Peritoneal Dialysis ; Peritoneal Dialysis, Continuous Ambulatory</subject><ispartof>Journal of clinical pharmacology, 1983-05, Vol.23 (5-6), p.252-256</ispartof><rights>1983 American College of Clinical Pharmacology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4092-8a8b0689c9d9c7da3c7ccb5e557f434e4a706f8f1e8c18b34e7f3239965bcd213</citedby><cites>FETCH-LOGICAL-c4092-8a8b0689c9d9c7da3c7ccb5e557f434e4a706f8f1e8c18b34e7f3239965bcd213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1552-4604.1983.tb02732.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1552-4604.1983.tb02732.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6875024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOGAN, FREDERICK J.</creatorcontrib><creatorcontrib>SAMPLINER, RICHARD E.</creatorcontrib><creatorcontrib>MAYERSOHN, MICHAEL</creatorcontrib><creatorcontrib>KAZAMA, RODNEY M.</creatorcontrib><creatorcontrib>PERRIER, DONALD</creatorcontrib><creatorcontrib>JONES, WILLIAM</creatorcontrib><creatorcontrib>MICHAEL, ULRICH F.</creatorcontrib><title>Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis.</description><subject>Aged</subject><subject>Cimetidine - blood</subject><subject>Cimetidine - metabolism</subject><subject>Guanidines - metabolism</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>Middle Aged</subject><subject>Peritoneal Dialysis</subject><subject>Peritoneal Dialysis, Continuous Ambulatory</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFu1DAQhi0EKkvLIyBFHLgljO04djhRpdBSrehKUPVoOY5TeUnsxXbE7tuTaFd772ms-We-sT6EPmIoMAD5vC0wYyQvKygLXAtapBYIp6TYv0Krc_QarQBqnBMO8Ba9i3ELgKuS4Qt0UQnOgJQr9NTY0STbWWeyGxt3PtpkvcusyzYqWeNSzB5dZ8Kzt-45a7xL1k1-itn12E6DSj4cso0JNnln1DAz1HCINl6hN70aonl_qpfo8fu3381dvn64_dFcr3NdQk1yoUQLlah13dWad4pqrnXLDGO8L2lpSsWh6kWPjdBYtHOH95TQuq5YqzuC6SX6dOTugv87mZjkaKM2w6CcmX8pBTDBKkHmwS_HQR18jMH0chfsqMJBYpCLVbmVizq5qJOLVXmyKvfz8ofTlakdTXdePWmc86_H_J8dzOEFZHnfbO6W54zIjwgbk9mfESr8kRWnnMmnn7fyZs3wrzXBckP_A8sXmFI</recordid><startdate>198305</startdate><enddate>198305</enddate><creator>KOGAN, FREDERICK J.</creator><creator>SAMPLINER, RICHARD E.</creator><creator>MAYERSOHN, MICHAEL</creator><creator>KAZAMA, RODNEY M.</creator><creator>PERRIER, DONALD</creator><creator>JONES, WILLIAM</creator><creator>MICHAEL, ULRICH F.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198305</creationdate><title>Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis</title><author>KOGAN, FREDERICK J. ; SAMPLINER, RICHARD E. ; MAYERSOHN, MICHAEL ; KAZAMA, RODNEY M. ; PERRIER, DONALD ; JONES, WILLIAM ; MICHAEL, ULRICH F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4092-8a8b0689c9d9c7da3c7ccb5e557f434e4a706f8f1e8c18b34e7f3239965bcd213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aged</topic><topic>Cimetidine - blood</topic><topic>Cimetidine - metabolism</topic><topic>Guanidines - metabolism</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>Middle Aged</topic><topic>Peritoneal Dialysis</topic><topic>Peritoneal Dialysis, Continuous Ambulatory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOGAN, FREDERICK J.</creatorcontrib><creatorcontrib>SAMPLINER, RICHARD E.</creatorcontrib><creatorcontrib>MAYERSOHN, MICHAEL</creatorcontrib><creatorcontrib>KAZAMA, RODNEY M.</creatorcontrib><creatorcontrib>PERRIER, DONALD</creatorcontrib><creatorcontrib>JONES, WILLIAM</creatorcontrib><creatorcontrib>MICHAEL, ULRICH F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOGAN, FREDERICK J.</au><au>SAMPLINER, RICHARD E.</au><au>MAYERSOHN, MICHAEL</au><au>KAZAMA, RODNEY M.</au><au>PERRIER, DONALD</au><au>JONES, WILLIAM</au><au>MICHAEL, ULRICH F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1983-05</date><risdate>1983</risdate><volume>23</volume><issue>5-6</issue><spage>252</spage><epage>256</epage><pages>252-256</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><abstract>: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6875024</pmid><doi>10.1002/j.1552-4604.1983.tb02732.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-2700 |
| ispartof | Journal of clinical pharmacology, 1983-05, Vol.23 (5-6), p.252-256 |
| issn | 0091-2700 1552-4604 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80585682 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Cimetidine - blood Cimetidine - metabolism Guanidines - metabolism Half-Life Humans Male Metabolic Clearance Rate Middle Aged Peritoneal Dialysis Peritoneal Dialysis, Continuous Ambulatory |
| title | Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis |
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