Do endogenous excitatory amino acids influence striatal dopamine release?
In vivo microdialysis techniques were used to examine whether endogenous excitatory amino acids exert a tonic facilitatory influence on striatal dopamine release. Local application of NMDA and non-NMDA antagonists at 10 μM was without an effect on basal dopamine release while 100 μM and 1 mM of thes...
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| Veröffentlicht in: | Brain research 1991-03, Vol.544 (2), p.329-330 |
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| container_title | Brain research |
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| creator | Moghaddam, Bita Gruen, Rand J. |
| description | In vivo microdialysis techniques were used to examine whether endogenous excitatory amino acids exert a tonic facilitatory influence on striatal dopamine release. Local application of NMDA and non-NMDA antagonists at 10 μM was without an effect on basal dopamine release while 100 μM and 1 mM of these drugs significantly enhanced the release. Our findings do not support the idea that excitatory amino acids have a tonic excitatory effect on striatal dopamine release. |
| doi_str_mv | 10.1016/0006-8993(91)90074-6 |
| format | Article |
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Psychology</subject><subject>Male</subject><subject>Microdialysis</subject><subject>N-Methylaspartate - antagonists & inhibitors</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq0KBFvafwBSLlTtITCOPxJfWlVAYaWVuLRna9aeIKNsvNhZBP-epLuCG5xG1jzzzvhh7JjDGQeuzwFAl40x4rvhPwxALUv9ic14U1elriTssdkrcsg-53w_PoUwcMAOKhDGyHrG5pexoN7HO-rjJhf05MKAQ0zPBa5CHwt0weci9G23od5RkYcUcMCu8HE9EVQk6ggz_frC9lvsMn3d1SP278_V34ubcnF7Pb_4vSid1HIoSaglaFPXzpNqlEJVS9MSd0bqVmoCV3lnYFnV2IgGuazQCKq8VLhUDQdxxL5tc9cpPmwoD3YVsqOuw57GL9gGxliu5IcgVwZ4DXwE5RZ0KeacqLXrFFaYni0HO6m2k0c7ebSG2_-qrR7HTnb5m-WK_OvQzu3YP931MTvs2oS9C_kt22gxnjCt_7nlaLT2GCjZ7MIk24dEbrA-hvcPeQGuspms</recordid><startdate>19910329</startdate><enddate>19910329</enddate><creator>Moghaddam, Bita</creator><creator>Gruen, Rand J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910329</creationdate><title>Do endogenous excitatory amino acids influence striatal dopamine release?</title><author>Moghaddam, Bita ; Gruen, Rand J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-e35b06977cde5855a5749fe1c946f46e0c2dc90b27a838a142a93e2d45ab58103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amino Acids - physiology</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Corpus Striatum - metabolism</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Excitatory amino acid</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Brain research, 1991-03, Vol.544 (2), p.329-330 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acids - physiology Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Corpus Striatum - metabolism Dopamine Dopamine - metabolism Excitatory amino acid Fundamental and applied biological sciences. Psychology Male Microdialysis N-Methylaspartate - antagonists & inhibitors Rats Rats, Inbred Strains Vertebrates: nervous system and sense organs |
| title | Do endogenous excitatory amino acids influence striatal dopamine release? |
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