Neurological Function of Immature Babies After Surfactant Replacement Therapy
Abstract Surfactant replacement therapy in patients with neonatal respiratory distress syndrome (RDS) is a new therapeutic approach. There is now convincing evidence that the incidence and severity of RDS can be reduced. Surfactant (CUROSURF) was intratracheally applied to a group of fifteen intubat...
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| Veröffentlicht in: | Neuropediatrics 1991-02, Vol.22 (1), p.43-44 |
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| container_title | Neuropediatrics |
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| creator | Amato, M. Hüppi, P. Markus, D. Herschkowitz, N. |
| description | Abstract
Surfactant replacement therapy in patients with neonatal respiratory distress syndrome (RDS) is a new therapeutic approach. There is now convincing evidence that the incidence and severity of RDS can be reduced. Surfactant (CUROSURF) was intratracheally applied to a group of fifteen intubated preterm infants with severe RDS (29±2.1 weeks of gestation and 1204±301 g birth weight) at 9.1 ±2.5 hours of life. For detection of potential neurological risk we performed serial ultrasound examinations (US), serial measurements of Creatine-Kinase Isoenzyme levels (CKBB) looking for the presence of human antibodies to different brain antigens (BSA) as markers for neonatal cerebral injury. Using these diagnostic methods, there was no evidence of any negative influence of surfactant therapy on cerebral function of treated preterm infants. |
| doi_str_mv | 10.1055/s-2008-1071414 |
| format | Article |
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Surfactant replacement therapy in patients with neonatal respiratory distress syndrome (RDS) is a new therapeutic approach. There is now convincing evidence that the incidence and severity of RDS can be reduced. Surfactant (CUROSURF) was intratracheally applied to a group of fifteen intubated preterm infants with severe RDS (29±2.1 weeks of gestation and 1204±301 g birth weight) at 9.1 ±2.5 hours of life. For detection of potential neurological risk we performed serial ultrasound examinations (US), serial measurements of Creatine-Kinase Isoenzyme levels (CKBB) looking for the presence of human antibodies to different brain antigens (BSA) as markers for neonatal cerebral injury. Using these diagnostic methods, there was no evidence of any negative influence of surfactant therapy on cerebral function of treated preterm infants.</description><identifier>ISSN: 0174-304X</identifier><identifier>EISSN: 1439-1899</identifier><identifier>DOI: 10.1055/s-2008-1071414</identifier><identifier>PMID: 2038427</identifier><identifier>CODEN: NRPDDB</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Autoantibodies - analysis ; Biological and medical sciences ; Brain - immunology ; Brain - physiopathology ; Brain Damage, Chronic - diagnosis ; Brain Damage, Chronic - diagnostic imaging ; Brain Damage, Chronic - physiopathology ; Cerebral Hemorrhage - diagnosis ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - physiopathology ; Creatine Kinase - blood ; Echoencephalography ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Follow-Up Studies ; Humans ; Infant, Newborn ; Intensive care medicine ; Isoenzymes ; Medical sciences ; Neurologic Examination ; Original article ; Pulmonary Surfactants - administration & dosage ; Respiratory Distress Syndrome, Newborn - diagnostic imaging ; Respiratory Distress Syndrome, Newborn - physiopathology ; Respiratory Distress Syndrome, Newborn - therapy</subject><ispartof>Neuropediatrics, 1991-02, Vol.22 (1), p.43-44</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-4823405fdeac654ce050a33dfa27aade4bce181444eecbc3584543f20564f5a53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2008-1071414.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4453914$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2038427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amato, M.</creatorcontrib><creatorcontrib>Hüppi, P.</creatorcontrib><creatorcontrib>Markus, D.</creatorcontrib><creatorcontrib>Herschkowitz, N.</creatorcontrib><title>Neurological Function of Immature Babies After Surfactant Replacement Therapy</title><title>Neuropediatrics</title><addtitle>Neuropediatrics</addtitle><description>Abstract
Surfactant replacement therapy in patients with neonatal respiratory distress syndrome (RDS) is a new therapeutic approach. There is now convincing evidence that the incidence and severity of RDS can be reduced. Surfactant (CUROSURF) was intratracheally applied to a group of fifteen intubated preterm infants with severe RDS (29±2.1 weeks of gestation and 1204±301 g birth weight) at 9.1 ±2.5 hours of life. For detection of potential neurological risk we performed serial ultrasound examinations (US), serial measurements of Creatine-Kinase Isoenzyme levels (CKBB) looking for the presence of human antibodies to different brain antigens (BSA) as markers for neonatal cerebral injury. Using these diagnostic methods, there was no evidence of any negative influence of surfactant therapy on cerebral function of treated preterm infants.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Autoantibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Brain - immunology</subject><subject>Brain - physiopathology</subject><subject>Brain Damage, Chronic - diagnosis</subject><subject>Brain Damage, Chronic - diagnostic imaging</subject><subject>Brain Damage, Chronic - physiopathology</subject><subject>Cerebral Hemorrhage - diagnosis</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>Cerebral Hemorrhage - physiopathology</subject><subject>Creatine Kinase - blood</subject><subject>Echoencephalography</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Isoenzymes</subject><subject>Medical sciences</subject><subject>Neurologic Examination</subject><subject>Original article</subject><subject>Pulmonary Surfactants - administration & dosage</subject><subject>Respiratory Distress Syndrome, Newborn - diagnostic imaging</subject><subject>Respiratory Distress Syndrome, Newborn - physiopathology</subject><subject>Respiratory Distress Syndrome, Newborn - therapy</subject><issn>0174-304X</issn><issn>1439-1899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhi1ERbfAlVulHBC3wDgeb5zjFrEUaWmlAhI3a9Y7ZoPysbWTA_8e04249TQjzfO-Iz1CnEm4lKD1VcwLAJNLKCVKPBAziarKpamqQzEDWWKuAJ-_im8xvgJIrGB-JI4KUAaLcibuf_EY-qZ_qR012XLs3FD3Xdb77K5taRgDZz9oXXPMFn7gkD2MwZMbqBuyP7xryHHLaX_ccqDd24n44qmJfDrNY_G0vHm8_pmvft_eXS9WuVO6HHI0hULQfsPk5hodgwZSauOpKIk2jGvH0khEZHbrlDGoUfkC9By9Jq2OxcW-dxf6vyPHwbZ1dNw01HE_RmsgRQyYBF7uQRf6GAN7uwt1S-HNSrAf_my0H_7s5C8Fvk_N47rlzSc-CUv38-lOMRnzgTpXx08MUavqX02-x4ZtnQzZ134MXTLyv7fvknmFvw</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>Amato, M.</creator><creator>Hüppi, P.</creator><creator>Markus, D.</creator><creator>Herschkowitz, N.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910201</creationdate><title>Neurological Function of Immature Babies After Surfactant Replacement Therapy</title><author>Amato, M. ; Hüppi, P. ; Markus, D. ; Herschkowitz, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4823405fdeac654ce050a33dfa27aade4bce181444eecbc3584543f20564f5a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Autoantibodies - analysis</topic><topic>Biological and medical sciences</topic><topic>Brain - immunology</topic><topic>Brain - physiopathology</topic><topic>Brain Damage, Chronic - diagnosis</topic><topic>Brain Damage, Chronic - diagnostic imaging</topic><topic>Brain Damage, Chronic - physiopathology</topic><topic>Cerebral Hemorrhage - diagnosis</topic><topic>Cerebral Hemorrhage - diagnostic imaging</topic><topic>Cerebral Hemorrhage - physiopathology</topic><topic>Creatine Kinase - blood</topic><topic>Echoencephalography</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Isoenzymes</topic><topic>Medical sciences</topic><topic>Neurologic Examination</topic><topic>Original article</topic><topic>Pulmonary Surfactants - administration & dosage</topic><topic>Respiratory Distress Syndrome, Newborn - diagnostic imaging</topic><topic>Respiratory Distress Syndrome, Newborn - physiopathology</topic><topic>Respiratory Distress Syndrome, Newborn - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amato, M.</creatorcontrib><creatorcontrib>Hüppi, P.</creatorcontrib><creatorcontrib>Markus, D.</creatorcontrib><creatorcontrib>Herschkowitz, N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amato, M.</au><au>Hüppi, P.</au><au>Markus, D.</au><au>Herschkowitz, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurological Function of Immature Babies After Surfactant Replacement Therapy</atitle><jtitle>Neuropediatrics</jtitle><addtitle>Neuropediatrics</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>22</volume><issue>1</issue><spage>43</spage><epage>44</epage><pages>43-44</pages><issn>0174-304X</issn><eissn>1439-1899</eissn><coden>NRPDDB</coden><abstract>Abstract
Surfactant replacement therapy in patients with neonatal respiratory distress syndrome (RDS) is a new therapeutic approach. There is now convincing evidence that the incidence and severity of RDS can be reduced. Surfactant (CUROSURF) was intratracheally applied to a group of fifteen intubated preterm infants with severe RDS (29±2.1 weeks of gestation and 1204±301 g birth weight) at 9.1 ±2.5 hours of life. For detection of potential neurological risk we performed serial ultrasound examinations (US), serial measurements of Creatine-Kinase Isoenzyme levels (CKBB) looking for the presence of human antibodies to different brain antigens (BSA) as markers for neonatal cerebral injury. Using these diagnostic methods, there was no evidence of any negative influence of surfactant therapy on cerebral function of treated preterm infants.</abstract><cop>Stuttgart</cop><pub>Thieme</pub><pmid>2038427</pmid><doi>10.1055/s-2008-1071414</doi><tpages>2</tpages></addata></record> |
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| ispartof | Neuropediatrics, 1991-02, Vol.22 (1), p.43-44 |
| issn | 0174-304X 1439-1899 |
| language | eng |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Autoantibodies - analysis Biological and medical sciences Brain - immunology Brain - physiopathology Brain Damage, Chronic - diagnosis Brain Damage, Chronic - diagnostic imaging Brain Damage, Chronic - physiopathology Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - physiopathology Creatine Kinase - blood Echoencephalography Emergency and intensive care: neonates and children. Prematurity. Sudden death Follow-Up Studies Humans Infant, Newborn Intensive care medicine Isoenzymes Medical sciences Neurologic Examination Original article Pulmonary Surfactants - administration & dosage Respiratory Distress Syndrome, Newborn - diagnostic imaging Respiratory Distress Syndrome, Newborn - physiopathology Respiratory Distress Syndrome, Newborn - therapy |
| title | Neurological Function of Immature Babies After Surfactant Replacement Therapy |
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